Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/s12872-019-1113-4 http://hdl.handle.net/11449/189178 |
Resumo: | Background: Information on the role of intermittent fasting (IF) on pathologic cardiac remodeling is scarce. We compared the effects of IF before and after myocardial infarction (MI) on rat cardiac remodeling and survival. Methods: Wistar rats were intermittently fasted (food available every other day) or fed ad libitum for 12 weeks and then divided into three groups: AL - fed ad libitum; AL/IF - fed AL before MI and IF after MI; and IF - fed IF before and after MI. Echocardiogram was performed before MI and 2 and 12 weeks after surgery. Isolated hearts were evaluated in Langendorff preparations. Results: Before surgery, body weight (BW) was lower in IF than AL. Final BW was lower in AL/IF and IF than AL. Perioperative mortality did not change between AL (31.3%) and IF (27.3%). Total mortality was lower in IF than AL. Before surgery, echocardiographic parameters did not differ between groups. Two weeks after surgery, MI size did not differ between groups. Twelve weeks after MI, left ventricular (LV) diastolic posterior wall thickness was lower in AL/IF and IF than AL. The percentage of variation of echocardiographic parameters between twelve and two weeks showed that MI size decreased in all groups and the reduction was higher in IF than AL/IF. In Langendorff preparations, LV volume at zero end-diastolic pressure (V0; AL: 0.41 ± 0.05; AL/IF: 0.34 ± 0.06; IF: 0.28 ± 0.05 mL) and at 25 mmHg end-diastolic pressure (V25; AL: 0.61 ± 0.05; AL/IF: 0.54 ± 0.07; IF: 0.44 ± 0.06 mL) was lower in AL/IF and IF than AL and V25 was lower in IF than AL/IF. V0/BW ratio was lower in IF than AL and LV weight/V0 ratio was higher in IF than AL. Myocyte diameter was lower in AL/IF and IF than AL (AL: 17.3 ± 1.70; AL/IF: 15.1 ± 2.21; IF: 13.4 ± 1.49 μm). Myocardial hydroxyproline concentration and gene expression of ANP, Serca 2a, and α- and β-myosin heavy chain did not differ between groups. Conclusion: Intermittent fasting initiated before or after MI reduces myocyte hypertrophy and LV dilation. Myocardial fibrosis and fetal gene expression are not modulated by feeding regimens. Benefit is more evident when intermittent fasting is initiated before rather than after MI. |
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Influence of intermittent fasting on myocardial infarction-induced cardiac remodelingCalorie restrictionEchocardiogramFetal gene expressionHeart failureIntermittent feedingIsolated heartLangendorff preparationMyocardial infarctionRatVentricular remodelingBackground: Information on the role of intermittent fasting (IF) on pathologic cardiac remodeling is scarce. We compared the effects of IF before and after myocardial infarction (MI) on rat cardiac remodeling and survival. Methods: Wistar rats were intermittently fasted (food available every other day) or fed ad libitum for 12 weeks and then divided into three groups: AL - fed ad libitum; AL/IF - fed AL before MI and IF after MI; and IF - fed IF before and after MI. Echocardiogram was performed before MI and 2 and 12 weeks after surgery. Isolated hearts were evaluated in Langendorff preparations. Results: Before surgery, body weight (BW) was lower in IF than AL. Final BW was lower in AL/IF and IF than AL. Perioperative mortality did not change between AL (31.3%) and IF (27.3%). Total mortality was lower in IF than AL. Before surgery, echocardiographic parameters did not differ between groups. Two weeks after surgery, MI size did not differ between groups. Twelve weeks after MI, left ventricular (LV) diastolic posterior wall thickness was lower in AL/IF and IF than AL. The percentage of variation of echocardiographic parameters between twelve and two weeks showed that MI size decreased in all groups and the reduction was higher in IF than AL/IF. In Langendorff preparations, LV volume at zero end-diastolic pressure (V0; AL: 0.41 ± 0.05; AL/IF: 0.34 ± 0.06; IF: 0.28 ± 0.05 mL) and at 25 mmHg end-diastolic pressure (V25; AL: 0.61 ± 0.05; AL/IF: 0.54 ± 0.07; IF: 0.44 ± 0.06 mL) was lower in AL/IF and IF than AL and V25 was lower in IF than AL/IF. V0/BW ratio was lower in IF than AL and LV weight/V0 ratio was higher in IF than AL. Myocyte diameter was lower in AL/IF and IF than AL (AL: 17.3 ± 1.70; AL/IF: 15.1 ± 2.21; IF: 13.4 ± 1.49 μm). Myocardial hydroxyproline concentration and gene expression of ANP, Serca 2a, and α- and β-myosin heavy chain did not differ between groups. Conclusion: Intermittent fasting initiated before or after MI reduces myocyte hypertrophy and LV dilation. Myocardial fibrosis and fetal gene expression are not modulated by feeding regimens. Benefit is more evident when intermittent fasting is initiated before rather than after MI.Internal Medicine Department Botucatu Medical School Sao Paulo State University UNESPDepartamento de Clinica Medica Faculdade de Medicina de Botucatu UNESP, Rubiao Junior, S/NItapeva Social and Agrarian Sciences College FAITFederal University of Mato Grosso Do sul Cidade Universitária, Av. Costa e Silva - PioneirosInternal Medicine Department Botucatu Medical School Sao Paulo State University UNESPDepartamento de Clinica Medica Faculdade de Medicina de Botucatu UNESP, Rubiao Junior, S/NUniversidade Estadual Paulista (Unesp)FAITCidade UniversitáriaOkoshi, K. [UNESP]Cezar, M. D.M. [UNESP]Polin, M. A.M. [UNESP]Paladino, J. R. [UNESP]Martinez, P. F.Oliveira, S. A.Lima, A. R.R. [UNESP]Damatto, R. L. [UNESP]Paiva, S. A.R. [UNESP]Zornoff, L. A.M. [UNESP]Okoshi, M. P. [UNESP]2019-10-06T16:32:21Z2019-10-06T16:32:21Z2019-05-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s12872-019-1113-4BMC Cardiovascular Disorders, v. 19, n. 1, 2019.1471-2261http://hdl.handle.net/11449/18917810.1186/s12872-019-1113-42-s2.0-85066411310Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Cardiovascular Disordersinfo:eu-repo/semantics/openAccess2024-08-14T17:22:25Zoai:repositorio.unesp.br:11449/189178Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling |
title |
Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling |
spellingShingle |
Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling Okoshi, K. [UNESP] Calorie restriction Echocardiogram Fetal gene expression Heart failure Intermittent feeding Isolated heart Langendorff preparation Myocardial infarction Rat Ventricular remodeling |
title_short |
Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling |
title_full |
Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling |
title_fullStr |
Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling |
title_full_unstemmed |
Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling |
title_sort |
Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling |
author |
Okoshi, K. [UNESP] |
author_facet |
Okoshi, K. [UNESP] Cezar, M. D.M. [UNESP] Polin, M. A.M. [UNESP] Paladino, J. R. [UNESP] Martinez, P. F. Oliveira, S. A. Lima, A. R.R. [UNESP] Damatto, R. L. [UNESP] Paiva, S. A.R. [UNESP] Zornoff, L. A.M. [UNESP] Okoshi, M. P. [UNESP] |
author_role |
author |
author2 |
Cezar, M. D.M. [UNESP] Polin, M. A.M. [UNESP] Paladino, J. R. [UNESP] Martinez, P. F. Oliveira, S. A. Lima, A. R.R. [UNESP] Damatto, R. L. [UNESP] Paiva, S. A.R. [UNESP] Zornoff, L. A.M. [UNESP] Okoshi, M. P. [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) FAIT Cidade Universitária |
dc.contributor.author.fl_str_mv |
Okoshi, K. [UNESP] Cezar, M. D.M. [UNESP] Polin, M. A.M. [UNESP] Paladino, J. R. [UNESP] Martinez, P. F. Oliveira, S. A. Lima, A. R.R. [UNESP] Damatto, R. L. [UNESP] Paiva, S. A.R. [UNESP] Zornoff, L. A.M. [UNESP] Okoshi, M. P. [UNESP] |
dc.subject.por.fl_str_mv |
Calorie restriction Echocardiogram Fetal gene expression Heart failure Intermittent feeding Isolated heart Langendorff preparation Myocardial infarction Rat Ventricular remodeling |
topic |
Calorie restriction Echocardiogram Fetal gene expression Heart failure Intermittent feeding Isolated heart Langendorff preparation Myocardial infarction Rat Ventricular remodeling |
description |
Background: Information on the role of intermittent fasting (IF) on pathologic cardiac remodeling is scarce. We compared the effects of IF before and after myocardial infarction (MI) on rat cardiac remodeling and survival. Methods: Wistar rats were intermittently fasted (food available every other day) or fed ad libitum for 12 weeks and then divided into three groups: AL - fed ad libitum; AL/IF - fed AL before MI and IF after MI; and IF - fed IF before and after MI. Echocardiogram was performed before MI and 2 and 12 weeks after surgery. Isolated hearts were evaluated in Langendorff preparations. Results: Before surgery, body weight (BW) was lower in IF than AL. Final BW was lower in AL/IF and IF than AL. Perioperative mortality did not change between AL (31.3%) and IF (27.3%). Total mortality was lower in IF than AL. Before surgery, echocardiographic parameters did not differ between groups. Two weeks after surgery, MI size did not differ between groups. Twelve weeks after MI, left ventricular (LV) diastolic posterior wall thickness was lower in AL/IF and IF than AL. The percentage of variation of echocardiographic parameters between twelve and two weeks showed that MI size decreased in all groups and the reduction was higher in IF than AL/IF. In Langendorff preparations, LV volume at zero end-diastolic pressure (V0; AL: 0.41 ± 0.05; AL/IF: 0.34 ± 0.06; IF: 0.28 ± 0.05 mL) and at 25 mmHg end-diastolic pressure (V25; AL: 0.61 ± 0.05; AL/IF: 0.54 ± 0.07; IF: 0.44 ± 0.06 mL) was lower in AL/IF and IF than AL and V25 was lower in IF than AL/IF. V0/BW ratio was lower in IF than AL and LV weight/V0 ratio was higher in IF than AL. Myocyte diameter was lower in AL/IF and IF than AL (AL: 17.3 ± 1.70; AL/IF: 15.1 ± 2.21; IF: 13.4 ± 1.49 μm). Myocardial hydroxyproline concentration and gene expression of ANP, Serca 2a, and α- and β-myosin heavy chain did not differ between groups. Conclusion: Intermittent fasting initiated before or after MI reduces myocyte hypertrophy and LV dilation. Myocardial fibrosis and fetal gene expression are not modulated by feeding regimens. Benefit is more evident when intermittent fasting is initiated before rather than after MI. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:32:21Z 2019-10-06T16:32:21Z 2019-05-28 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s12872-019-1113-4 BMC Cardiovascular Disorders, v. 19, n. 1, 2019. 1471-2261 http://hdl.handle.net/11449/189178 10.1186/s12872-019-1113-4 2-s2.0-85066411310 |
url |
http://dx.doi.org/10.1186/s12872-019-1113-4 http://hdl.handle.net/11449/189178 |
identifier_str_mv |
BMC Cardiovascular Disorders, v. 19, n. 1, 2019. 1471-2261 10.1186/s12872-019-1113-4 2-s2.0-85066411310 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMC Cardiovascular Disorders |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128116664565760 |