Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.12659/MSM.882732 http://hdl.handle.net/11449/226810 |
Resumo: | Background: The consequences of aggressive therapy following a myocardial infarction (MI) on ventricular remodeling are not well established. Thus, the objective of this study was to analyze the prevalence, clinical characteristics, and predictors of left ventricular remodeling in the era of modern medical therapy. Material/Methods: Clinical characteristics and echocardiographic data were analyzed in 66 consecutive patients with anterior infarction at admission and at 6-month follow-up. Ventricular remodeling was defined as an increase of 10% in ventricular end-systolic or end-diastolic diameter. Results: In our study, 58% of patients presented with ventricular remodeling. Patients with remodeling possessed higher total plasma creatine kinase (CPK), MB-fraction (CPK-MB), heart rate, heart failure, shortness of breath, and reperfusion therapy than patients without remodeling. In contrast, patients with remodeling had a smaller ejection fraction, E-Wave deceleration time (EDT), and early (E' Wave) and late (A' Wave) diastolic mitral annulus velocity (average of septal and lateral walls), but a higher E/E' than patients without remodeling. Patients with remodeling used more diuretics, digoxin, oral anticoagulants and aldosterone antagonists than patients without remodeling. In the multivariate analyses, only E' Wave was an independent predictor of ventricular remodeling. Each 1 unit increase in the E' Wave was associated with a 59% increased odds of ventricular remodeling. Conclusions: In patients with anterior MI, despite contemporary treatment, ventricular remodeling is still a common event. In addition, diastolic function can have an important role as a predictor of remodeling in this scenario. © Med Sci Monit, 2012. |
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Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapyPredictorsRemodelingVentricular dilationBackground: The consequences of aggressive therapy following a myocardial infarction (MI) on ventricular remodeling are not well established. Thus, the objective of this study was to analyze the prevalence, clinical characteristics, and predictors of left ventricular remodeling in the era of modern medical therapy. Material/Methods: Clinical characteristics and echocardiographic data were analyzed in 66 consecutive patients with anterior infarction at admission and at 6-month follow-up. Ventricular remodeling was defined as an increase of 10% in ventricular end-systolic or end-diastolic diameter. Results: In our study, 58% of patients presented with ventricular remodeling. Patients with remodeling possessed higher total plasma creatine kinase (CPK), MB-fraction (CPK-MB), heart rate, heart failure, shortness of breath, and reperfusion therapy than patients without remodeling. In contrast, patients with remodeling had a smaller ejection fraction, E-Wave deceleration time (EDT), and early (E' Wave) and late (A' Wave) diastolic mitral annulus velocity (average of septal and lateral walls), but a higher E/E' than patients without remodeling. Patients with remodeling used more diuretics, digoxin, oral anticoagulants and aldosterone antagonists than patients without remodeling. In the multivariate analyses, only E' Wave was an independent predictor of ventricular remodeling. Each 1 unit increase in the E' Wave was associated with a 59% increased odds of ventricular remodeling. Conclusions: In patients with anterior MI, despite contemporary treatment, ventricular remodeling is still a common event. In addition, diastolic function can have an important role as a predictor of remodeling in this scenario. © Med Sci Monit, 2012.Department of Internal Medicine Botucatu Medical School UNESP - São Paulo State University, Botucatu, CEP: 18618-970Department of Internal Medicine Botucatu Medical School UNESP - São Paulo State University, Botucatu, CEP: 18618-970Universidade Estadual Paulista (UNESP)Farah, Elaine [UNESP]Cogni, Ana Lucia [UNESP]Minicucci, Marcos F. [UNESP]Azevedo, Paula S. [UNESP]Okoshi, Katashi [UNESP]Matsubara, Beatriz B. [UNESP]Zanati, Silméia G. [UNESP]Haggeman, Rodrigo [UNESP]Paiva, Sergio A.R. [UNESP]Zornoff, Leonardo A. M. [UNESP]2022-04-29T02:56:57Z2022-04-29T02:56:57Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.12659/MSM.882732Medical Science Monitor, v. 18, n. 5, 2012.1643-37501234-1010http://hdl.handle.net/11449/22681010.12659/MSM.8827322-s2.0-84860682018Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Science Monitorinfo:eu-repo/semantics/openAccess2024-08-14T17:23:32Zoai:repositorio.unesp.br:11449/226810Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy |
title |
Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy |
spellingShingle |
Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy Farah, Elaine [UNESP] Predictors Remodeling Ventricular dilation |
title_short |
Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy |
title_full |
Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy |
title_fullStr |
Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy |
title_full_unstemmed |
Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy |
title_sort |
Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy |
author |
Farah, Elaine [UNESP] |
author_facet |
Farah, Elaine [UNESP] Cogni, Ana Lucia [UNESP] Minicucci, Marcos F. [UNESP] Azevedo, Paula S. [UNESP] Okoshi, Katashi [UNESP] Matsubara, Beatriz B. [UNESP] Zanati, Silméia G. [UNESP] Haggeman, Rodrigo [UNESP] Paiva, Sergio A.R. [UNESP] Zornoff, Leonardo A. M. [UNESP] |
author_role |
author |
author2 |
Cogni, Ana Lucia [UNESP] Minicucci, Marcos F. [UNESP] Azevedo, Paula S. [UNESP] Okoshi, Katashi [UNESP] Matsubara, Beatriz B. [UNESP] Zanati, Silméia G. [UNESP] Haggeman, Rodrigo [UNESP] Paiva, Sergio A.R. [UNESP] Zornoff, Leonardo A. M. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Farah, Elaine [UNESP] Cogni, Ana Lucia [UNESP] Minicucci, Marcos F. [UNESP] Azevedo, Paula S. [UNESP] Okoshi, Katashi [UNESP] Matsubara, Beatriz B. [UNESP] Zanati, Silméia G. [UNESP] Haggeman, Rodrigo [UNESP] Paiva, Sergio A.R. [UNESP] Zornoff, Leonardo A. M. [UNESP] |
dc.subject.por.fl_str_mv |
Predictors Remodeling Ventricular dilation |
topic |
Predictors Remodeling Ventricular dilation |
description |
Background: The consequences of aggressive therapy following a myocardial infarction (MI) on ventricular remodeling are not well established. Thus, the objective of this study was to analyze the prevalence, clinical characteristics, and predictors of left ventricular remodeling in the era of modern medical therapy. Material/Methods: Clinical characteristics and echocardiographic data were analyzed in 66 consecutive patients with anterior infarction at admission and at 6-month follow-up. Ventricular remodeling was defined as an increase of 10% in ventricular end-systolic or end-diastolic diameter. Results: In our study, 58% of patients presented with ventricular remodeling. Patients with remodeling possessed higher total plasma creatine kinase (CPK), MB-fraction (CPK-MB), heart rate, heart failure, shortness of breath, and reperfusion therapy than patients without remodeling. In contrast, patients with remodeling had a smaller ejection fraction, E-Wave deceleration time (EDT), and early (E' Wave) and late (A' Wave) diastolic mitral annulus velocity (average of septal and lateral walls), but a higher E/E' than patients without remodeling. Patients with remodeling used more diuretics, digoxin, oral anticoagulants and aldosterone antagonists than patients without remodeling. In the multivariate analyses, only E' Wave was an independent predictor of ventricular remodeling. Each 1 unit increase in the E' Wave was associated with a 59% increased odds of ventricular remodeling. Conclusions: In patients with anterior MI, despite contemporary treatment, ventricular remodeling is still a common event. In addition, diastolic function can have an important role as a predictor of remodeling in this scenario. © Med Sci Monit, 2012. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2022-04-29T02:56:57Z 2022-04-29T02:56:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.12659/MSM.882732 Medical Science Monitor, v. 18, n. 5, 2012. 1643-3750 1234-1010 http://hdl.handle.net/11449/226810 10.12659/MSM.882732 2-s2.0-84860682018 |
url |
http://dx.doi.org/10.12659/MSM.882732 http://hdl.handle.net/11449/226810 |
identifier_str_mv |
Medical Science Monitor, v. 18, n. 5, 2012. 1643-3750 1234-1010 10.12659/MSM.882732 2-s2.0-84860682018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medical Science Monitor |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128166834733056 |