Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy

Detalhes bibliográficos
Autor(a) principal: Farah, Elaine [UNESP]
Data de Publicação: 2012
Outros Autores: Cogni, Ana Lucia [UNESP], Minicucci, Marcos F. [UNESP], Azevedo, Paula S. [UNESP], Okoshi, Katashi [UNESP], Matsubara, Beatriz B. [UNESP], Zanati, Silméia G. [UNESP], Haggeman, Rodrigo [UNESP], Paiva, Sergio A.R. [UNESP], Zornoff, Leonardo A. M. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.12659/MSM.882732
http://hdl.handle.net/11449/226810
Resumo: Background: The consequences of aggressive therapy following a myocardial infarction (MI) on ventricular remodeling are not well established. Thus, the objective of this study was to analyze the prevalence, clinical characteristics, and predictors of left ventricular remodeling in the era of modern medical therapy. Material/Methods: Clinical characteristics and echocardiographic data were analyzed in 66 consecutive patients with anterior infarction at admission and at 6-month follow-up. Ventricular remodeling was defined as an increase of 10% in ventricular end-systolic or end-diastolic diameter. Results: In our study, 58% of patients presented with ventricular remodeling. Patients with remodeling possessed higher total plasma creatine kinase (CPK), MB-fraction (CPK-MB), heart rate, heart failure, shortness of breath, and reperfusion therapy than patients without remodeling. In contrast, patients with remodeling had a smaller ejection fraction, E-Wave deceleration time (EDT), and early (E' Wave) and late (A' Wave) diastolic mitral annulus velocity (average of septal and lateral walls), but a higher E/E' than patients without remodeling. Patients with remodeling used more diuretics, digoxin, oral anticoagulants and aldosterone antagonists than patients without remodeling. In the multivariate analyses, only E' Wave was an independent predictor of ventricular remodeling. Each 1 unit increase in the E' Wave was associated with a 59% increased odds of ventricular remodeling. Conclusions: In patients with anterior MI, despite contemporary treatment, ventricular remodeling is still a common event. In addition, diastolic function can have an important role as a predictor of remodeling in this scenario. © Med Sci Monit, 2012.
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spelling Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapyPredictorsRemodelingVentricular dilationBackground: The consequences of aggressive therapy following a myocardial infarction (MI) on ventricular remodeling are not well established. Thus, the objective of this study was to analyze the prevalence, clinical characteristics, and predictors of left ventricular remodeling in the era of modern medical therapy. Material/Methods: Clinical characteristics and echocardiographic data were analyzed in 66 consecutive patients with anterior infarction at admission and at 6-month follow-up. Ventricular remodeling was defined as an increase of 10% in ventricular end-systolic or end-diastolic diameter. Results: In our study, 58% of patients presented with ventricular remodeling. Patients with remodeling possessed higher total plasma creatine kinase (CPK), MB-fraction (CPK-MB), heart rate, heart failure, shortness of breath, and reperfusion therapy than patients without remodeling. In contrast, patients with remodeling had a smaller ejection fraction, E-Wave deceleration time (EDT), and early (E' Wave) and late (A' Wave) diastolic mitral annulus velocity (average of septal and lateral walls), but a higher E/E' than patients without remodeling. Patients with remodeling used more diuretics, digoxin, oral anticoagulants and aldosterone antagonists than patients without remodeling. In the multivariate analyses, only E' Wave was an independent predictor of ventricular remodeling. Each 1 unit increase in the E' Wave was associated with a 59% increased odds of ventricular remodeling. Conclusions: In patients with anterior MI, despite contemporary treatment, ventricular remodeling is still a common event. In addition, diastolic function can have an important role as a predictor of remodeling in this scenario. © Med Sci Monit, 2012.Department of Internal Medicine Botucatu Medical School UNESP - São Paulo State University, Botucatu, CEP: 18618-970Department of Internal Medicine Botucatu Medical School UNESP - São Paulo State University, Botucatu, CEP: 18618-970Universidade Estadual Paulista (UNESP)Farah, Elaine [UNESP]Cogni, Ana Lucia [UNESP]Minicucci, Marcos F. [UNESP]Azevedo, Paula S. [UNESP]Okoshi, Katashi [UNESP]Matsubara, Beatriz B. [UNESP]Zanati, Silméia G. [UNESP]Haggeman, Rodrigo [UNESP]Paiva, Sergio A.R. [UNESP]Zornoff, Leonardo A. M. [UNESP]2022-04-29T02:56:57Z2022-04-29T02:56:57Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.12659/MSM.882732Medical Science Monitor, v. 18, n. 5, 2012.1643-37501234-1010http://hdl.handle.net/11449/22681010.12659/MSM.8827322-s2.0-84860682018Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Science Monitorinfo:eu-repo/semantics/openAccess2024-08-14T17:23:32Zoai:repositorio.unesp.br:11449/226810Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy
title Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy
spellingShingle Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy
Farah, Elaine [UNESP]
Predictors
Remodeling
Ventricular dilation
title_short Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy
title_full Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy
title_fullStr Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy
title_full_unstemmed Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy
title_sort Prevalence and predictors of ventricular remodeling after anterior myocardial infarction in the era of modern medical therapy
author Farah, Elaine [UNESP]
author_facet Farah, Elaine [UNESP]
Cogni, Ana Lucia [UNESP]
Minicucci, Marcos F. [UNESP]
Azevedo, Paula S. [UNESP]
Okoshi, Katashi [UNESP]
Matsubara, Beatriz B. [UNESP]
Zanati, Silméia G. [UNESP]
Haggeman, Rodrigo [UNESP]
Paiva, Sergio A.R. [UNESP]
Zornoff, Leonardo A. M. [UNESP]
author_role author
author2 Cogni, Ana Lucia [UNESP]
Minicucci, Marcos F. [UNESP]
Azevedo, Paula S. [UNESP]
Okoshi, Katashi [UNESP]
Matsubara, Beatriz B. [UNESP]
Zanati, Silméia G. [UNESP]
Haggeman, Rodrigo [UNESP]
Paiva, Sergio A.R. [UNESP]
Zornoff, Leonardo A. M. [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Farah, Elaine [UNESP]
Cogni, Ana Lucia [UNESP]
Minicucci, Marcos F. [UNESP]
Azevedo, Paula S. [UNESP]
Okoshi, Katashi [UNESP]
Matsubara, Beatriz B. [UNESP]
Zanati, Silméia G. [UNESP]
Haggeman, Rodrigo [UNESP]
Paiva, Sergio A.R. [UNESP]
Zornoff, Leonardo A. M. [UNESP]
dc.subject.por.fl_str_mv Predictors
Remodeling
Ventricular dilation
topic Predictors
Remodeling
Ventricular dilation
description Background: The consequences of aggressive therapy following a myocardial infarction (MI) on ventricular remodeling are not well established. Thus, the objective of this study was to analyze the prevalence, clinical characteristics, and predictors of left ventricular remodeling in the era of modern medical therapy. Material/Methods: Clinical characteristics and echocardiographic data were analyzed in 66 consecutive patients with anterior infarction at admission and at 6-month follow-up. Ventricular remodeling was defined as an increase of 10% in ventricular end-systolic or end-diastolic diameter. Results: In our study, 58% of patients presented with ventricular remodeling. Patients with remodeling possessed higher total plasma creatine kinase (CPK), MB-fraction (CPK-MB), heart rate, heart failure, shortness of breath, and reperfusion therapy than patients without remodeling. In contrast, patients with remodeling had a smaller ejection fraction, E-Wave deceleration time (EDT), and early (E' Wave) and late (A' Wave) diastolic mitral annulus velocity (average of septal and lateral walls), but a higher E/E' than patients without remodeling. Patients with remodeling used more diuretics, digoxin, oral anticoagulants and aldosterone antagonists than patients without remodeling. In the multivariate analyses, only E' Wave was an independent predictor of ventricular remodeling. Each 1 unit increase in the E' Wave was associated with a 59% increased odds of ventricular remodeling. Conclusions: In patients with anterior MI, despite contemporary treatment, ventricular remodeling is still a common event. In addition, diastolic function can have an important role as a predictor of remodeling in this scenario. © Med Sci Monit, 2012.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
2022-04-29T02:56:57Z
2022-04-29T02:56:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.12659/MSM.882732
Medical Science Monitor, v. 18, n. 5, 2012.
1643-3750
1234-1010
http://hdl.handle.net/11449/226810
10.12659/MSM.882732
2-s2.0-84860682018
url http://dx.doi.org/10.12659/MSM.882732
http://hdl.handle.net/11449/226810
identifier_str_mv Medical Science Monitor, v. 18, n. 5, 2012.
1643-3750
1234-1010
10.12659/MSM.882732
2-s2.0-84860682018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medical Science Monitor
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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