Serum homocysteine and physical exercise in patients with Parkinson's disease

Detalhes bibliográficos
Autor(a) principal: Crispim Nascimento, Carla Manuela [UNESP]
Data de Publicação: 2011
Outros Autores: Stella, Florindo [UNESP], Garlipp, Celia Regina, Santos, Ruth Ferreira [UNESP], Gobbi, Sebastiao [UNESP], Bucken Gobbi, Lilian Teresa [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1111/j.1479-8301.2011.00356.x
http://hdl.handle.net/11449/20851
Resumo: Background: Hyperhomocysteinemia is a major risk factor for cerebral and peripheral vascular diseases, as well as cortical and hippocampal injury, including an increased risk of dementia and cognitive impairment. Elevated serum homocysteine (Hcy) concentrations are common in patients with Parkinson's disease (PD) who have been treated with levodopa; however, physical exercises can help reduce Hcy concentrations. The aim of the present study was to compare serum Hcy levels in patients with PD who partook in regular physical exercises, sedentary PD patients, and healthy controls.Methods: Sixty individuals were enrolled in the present study across three groups: (i) 17 patients who did not partake of any type of exercise; (ii) 24 PD patients who exercised regularly; and (iii) 19 healthy individuals who did not exercise regularly. All participants were evaluated by Hoehn and Yahr scale, the Unified Parkinson's Disease Rating Scale (UPDRS) and Schwab and England scale (measure daily functionality). The serum levels of Hcy were analyzed by blood samples collected of each participant. An analysis of variance and a Tukey's post hoc test were applied to compare and to verify differences between groups. Pearson's correlation and stepwise multiple regression analyses were used to consider the association between several variables.Results: Mean plasma Hcy concentrations in individuals who exercised regularly were similar to those in the healthy controls and significantly lower than those in the group that did not exercise at all (P = 0.000). In addition, patients who did not exercise were receiving significantly higher doses of levodopa than those patients who exercised regularly (P = 0.001). A positive relationship between levodopa dose and Hcy concentrations (R(2) = 0.27; P = 0.03) was observed in patients who did not exercise, but not in those patients who exercised regularly (R(2) = 0.023; P = 0.15).Conclusions: The results of the present study suggest that, even with regular levodopa therapy, Hcy concentrations in PD patients who exercise regularly are significantly lower than in patients who do not exercise and are similar Hcy concentrations in healthy controls.
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spelling Serum homocysteine and physical exercise in patients with Parkinson's diseasehomocysteineParkinson's diseasephysical exerciseBackground: Hyperhomocysteinemia is a major risk factor for cerebral and peripheral vascular diseases, as well as cortical and hippocampal injury, including an increased risk of dementia and cognitive impairment. Elevated serum homocysteine (Hcy) concentrations are common in patients with Parkinson's disease (PD) who have been treated with levodopa; however, physical exercises can help reduce Hcy concentrations. The aim of the present study was to compare serum Hcy levels in patients with PD who partook in regular physical exercises, sedentary PD patients, and healthy controls.Methods: Sixty individuals were enrolled in the present study across three groups: (i) 17 patients who did not partake of any type of exercise; (ii) 24 PD patients who exercised regularly; and (iii) 19 healthy individuals who did not exercise regularly. All participants were evaluated by Hoehn and Yahr scale, the Unified Parkinson's Disease Rating Scale (UPDRS) and Schwab and England scale (measure daily functionality). The serum levels of Hcy were analyzed by blood samples collected of each participant. An analysis of variance and a Tukey's post hoc test were applied to compare and to verify differences between groups. Pearson's correlation and stepwise multiple regression analyses were used to consider the association between several variables.Results: Mean plasma Hcy concentrations in individuals who exercised regularly were similar to those in the healthy controls and significantly lower than those in the group that did not exercise at all (P = 0.000). In addition, patients who did not exercise were receiving significantly higher doses of levodopa than those patients who exercised regularly (P = 0.001). A positive relationship between levodopa dose and Hcy concentrations (R(2) = 0.27; P = 0.03) was observed in patients who did not exercise, but not in those patients who exercised regularly (R(2) = 0.023; P = 0.15).Conclusions: The results of the present study suggest that, even with regular levodopa therapy, Hcy concentrations in PD patients who exercise regularly are significantly lower than in patients who do not exercise and are similar Hcy concentrations in healthy controls.São Paulo State Univ, Dept Phys Educ, Biosci Inst, Lab Aging & Phys Act LAFE, São Paulo, BrazilUniv Estadual Campinas, Fac Med Sci, Clin Pathol Lab, Campinas, SP, BrazilFed Univ ABC, Math Computat & Cognit Ctr, São Paulo, BrazilSão Paulo State Univ, Dept Phys Educ, Biosci Inst, Lab Posture & Locomot Study LEPLO, São Paulo, BrazilSão Paulo State Univ, Dept Phys Educ, Biosci Inst, Lab Aging & Phys Act LAFE, São Paulo, BrazilSão Paulo State Univ, Dept Phys Educ, Biosci Inst, Lab Posture & Locomot Study LEPLO, São Paulo, BrazilWiley-BlackwellUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Universidade Federal do ABC (UFABC)Crispim Nascimento, Carla Manuela [UNESP]Stella, Florindo [UNESP]Garlipp, Celia ReginaSantos, Ruth Ferreira [UNESP]Gobbi, Sebastiao [UNESP]Bucken Gobbi, Lilian Teresa [UNESP]2013-09-30T18:49:07Z2014-05-20T13:58:41Z2013-09-30T18:49:07Z2014-05-20T13:58:41Z2011-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article105-112http://dx.doi.org/10.1111/j.1479-8301.2011.00356.xPsychogeriatrics. Malden: Wiley-blackwell, v. 11, n. 2, p. 105-112, 2011.1346-3500http://hdl.handle.net/11449/2085110.1111/j.1479-8301.2011.00356.xWOS:00029226990000579643862406533809868835271822421Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPsychogeriatrics1.2090,459info:eu-repo/semantics/openAccess2021-10-22T19:32:45Zoai:repositorio.unesp.br:11449/20851Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:00:52.453762Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Serum homocysteine and physical exercise in patients with Parkinson's disease
title Serum homocysteine and physical exercise in patients with Parkinson's disease
spellingShingle Serum homocysteine and physical exercise in patients with Parkinson's disease
Crispim Nascimento, Carla Manuela [UNESP]
homocysteine
Parkinson's disease
physical exercise
title_short Serum homocysteine and physical exercise in patients with Parkinson's disease
title_full Serum homocysteine and physical exercise in patients with Parkinson's disease
title_fullStr Serum homocysteine and physical exercise in patients with Parkinson's disease
title_full_unstemmed Serum homocysteine and physical exercise in patients with Parkinson's disease
title_sort Serum homocysteine and physical exercise in patients with Parkinson's disease
author Crispim Nascimento, Carla Manuela [UNESP]
author_facet Crispim Nascimento, Carla Manuela [UNESP]
Stella, Florindo [UNESP]
Garlipp, Celia Regina
Santos, Ruth Ferreira [UNESP]
Gobbi, Sebastiao [UNESP]
Bucken Gobbi, Lilian Teresa [UNESP]
author_role author
author2 Stella, Florindo [UNESP]
Garlipp, Celia Regina
Santos, Ruth Ferreira [UNESP]
Gobbi, Sebastiao [UNESP]
Bucken Gobbi, Lilian Teresa [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal do ABC (UFABC)
dc.contributor.author.fl_str_mv Crispim Nascimento, Carla Manuela [UNESP]
Stella, Florindo [UNESP]
Garlipp, Celia Regina
Santos, Ruth Ferreira [UNESP]
Gobbi, Sebastiao [UNESP]
Bucken Gobbi, Lilian Teresa [UNESP]
dc.subject.por.fl_str_mv homocysteine
Parkinson's disease
physical exercise
topic homocysteine
Parkinson's disease
physical exercise
description Background: Hyperhomocysteinemia is a major risk factor for cerebral and peripheral vascular diseases, as well as cortical and hippocampal injury, including an increased risk of dementia and cognitive impairment. Elevated serum homocysteine (Hcy) concentrations are common in patients with Parkinson's disease (PD) who have been treated with levodopa; however, physical exercises can help reduce Hcy concentrations. The aim of the present study was to compare serum Hcy levels in patients with PD who partook in regular physical exercises, sedentary PD patients, and healthy controls.Methods: Sixty individuals were enrolled in the present study across three groups: (i) 17 patients who did not partake of any type of exercise; (ii) 24 PD patients who exercised regularly; and (iii) 19 healthy individuals who did not exercise regularly. All participants were evaluated by Hoehn and Yahr scale, the Unified Parkinson's Disease Rating Scale (UPDRS) and Schwab and England scale (measure daily functionality). The serum levels of Hcy were analyzed by blood samples collected of each participant. An analysis of variance and a Tukey's post hoc test were applied to compare and to verify differences between groups. Pearson's correlation and stepwise multiple regression analyses were used to consider the association between several variables.Results: Mean plasma Hcy concentrations in individuals who exercised regularly were similar to those in the healthy controls and significantly lower than those in the group that did not exercise at all (P = 0.000). In addition, patients who did not exercise were receiving significantly higher doses of levodopa than those patients who exercised regularly (P = 0.001). A positive relationship between levodopa dose and Hcy concentrations (R(2) = 0.27; P = 0.03) was observed in patients who did not exercise, but not in those patients who exercised regularly (R(2) = 0.023; P = 0.15).Conclusions: The results of the present study suggest that, even with regular levodopa therapy, Hcy concentrations in PD patients who exercise regularly are significantly lower than in patients who do not exercise and are similar Hcy concentrations in healthy controls.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
2013-09-30T18:49:07Z
2013-09-30T18:49:07Z
2014-05-20T13:58:41Z
2014-05-20T13:58:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/j.1479-8301.2011.00356.x
Psychogeriatrics. Malden: Wiley-blackwell, v. 11, n. 2, p. 105-112, 2011.
1346-3500
http://hdl.handle.net/11449/20851
10.1111/j.1479-8301.2011.00356.x
WOS:000292269900005
7964386240653380
9868835271822421
url http://dx.doi.org/10.1111/j.1479-8301.2011.00356.x
http://hdl.handle.net/11449/20851
identifier_str_mv Psychogeriatrics. Malden: Wiley-blackwell, v. 11, n. 2, p. 105-112, 2011.
1346-3500
10.1111/j.1479-8301.2011.00356.x
WOS:000292269900005
7964386240653380
9868835271822421
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Psychogeriatrics
1.209
0,459
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv 105-112
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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