Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency

Detalhes bibliográficos
Autor(a) principal: Al-Ouqaili, Mushtak T.S.
Data de Publicação: 2023
Outros Autores: Saleh, Raed Obaid, Amin, Hawraz Ibrahim M., Jawhar, Zanko Hassan, Akbarizadeh, Majid Reza, Naderifar, Mahin, Issa, Kovan Dilawer, Gavilán, Juan Carlos Orosco, Nobre, Marcos Augusto Lima [UNESP], Jalil, Abduladheem Turki, Akhavan-Sigari, Reza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.arabjc.2023.104704
http://hdl.handle.net/11449/248484
Resumo: One of the current concerns to human health is antibiotic resistance, which promotes the use of antibiotics that are more harmful, expensive, and ineffective. In this condition, researchers are turning to innovative options to combat this alarming situation. Combining herbal medicine with nanotechnology has created a new strategy to increase the effectiveness of phytochemical compounds in overcoming antimicrobial resistance. Pistacia atlantica is one of the promising herbs with medicinal benefits, but its poor solubility in biological fluids is challenging. In this regard, we seek to evaluate the antibacterial efficacy of Pistacia atlantica extract-loaded nanovesicle. Cholesterol, Span 40, and Pluronic F127 modified nanoformulation was developed using an environmentally friendly improved heating technique, and it was evaluated for size distribution, zeta potential, morphology, entrapment efficiency (EE%), release behavior, stability, and antimicrobial performance. By using DLS, spherical nanovesicles were identified with a size distribution of 50–150 nm and a zeta potential of −43 mV. The extract's encapsulation efficiency was 72.03%. The developed loaded nanovesicles demonstrated controlled extract release in the tested 96 h and storage stability of at least 12 months at 25 °C. Also, Comparing the two samples, the encapsulated extract had greater antibacterial activity against Candida albicans, Staphylococcus aureus, and Pseudomonas plecoglossicida with MIC of 1320, 570, and 1100 µg/mL, respectively. Besides reducing the misuse of antibiotics by allowing for the controlled release of drugs made from natural sources, we expect the findings described here to help provide alternative plant-based formulations with greater stability and antibacterial activity.
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spelling Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiencyAnti-microbial effectsNanovesiclePistacia atlantica extractPluronic surfactantOne of the current concerns to human health is antibiotic resistance, which promotes the use of antibiotics that are more harmful, expensive, and ineffective. In this condition, researchers are turning to innovative options to combat this alarming situation. Combining herbal medicine with nanotechnology has created a new strategy to increase the effectiveness of phytochemical compounds in overcoming antimicrobial resistance. Pistacia atlantica is one of the promising herbs with medicinal benefits, but its poor solubility in biological fluids is challenging. In this regard, we seek to evaluate the antibacterial efficacy of Pistacia atlantica extract-loaded nanovesicle. Cholesterol, Span 40, and Pluronic F127 modified nanoformulation was developed using an environmentally friendly improved heating technique, and it was evaluated for size distribution, zeta potential, morphology, entrapment efficiency (EE%), release behavior, stability, and antimicrobial performance. By using DLS, spherical nanovesicles were identified with a size distribution of 50–150 nm and a zeta potential of −43 mV. The extract's encapsulation efficiency was 72.03%. The developed loaded nanovesicles demonstrated controlled extract release in the tested 96 h and storage stability of at least 12 months at 25 °C. Also, Comparing the two samples, the encapsulated extract had greater antibacterial activity against Candida albicans, Staphylococcus aureus, and Pseudomonas plecoglossicida with MIC of 1320, 570, and 1100 µg/mL, respectively. Besides reducing the misuse of antibiotics by allowing for the controlled release of drugs made from natural sources, we expect the findings described here to help provide alternative plant-based formulations with greater stability and antibacterial activity.Department of Microbiology College of Medicine University of Anbar, AnbarDepartment of Medical Laboratory Techniques Al-Maarif University CollegeChemistry Department Salahaddin University-ErbilDepartment of Medical Biochemical Analysis Cihan University-ErbilMedical Laboratory Science Department College of Health Science Lebanese French UniversityClinical Biochemistry Department College of Health Sciences Hawler Medical UniversityAmir Al Momenin Hospital Zabol University of Medical SciencesMedical Analysis Department Applied Science Faculty Tishk International University, Kurdistan RegionUniversidad Privada del Norte, Campus VirtualDepartment of Physics School of Technology and Sciences Sao Paulo State University – UNESP Presidente Prudente BrazilMedical Laboratories Techniques Department Al-Mustaqbal University College, BabylonDepartment of Neurosurgery University Medical Center TuebingenDepartment of Health Care Management and Clinical Research Collegium Humanum Warsaw Management UniversityDepartment of Physics School of Technology and Sciences Sao Paulo State University – UNESP Presidente Prudente BrazilUniversity of AnbarAl-Maarif University CollegeSalahaddin University-ErbilCihan University-ErbilLebanese French UniversityHawler Medical UniversityZabol University of Medical SciencesTishk International UniversityUniversidad Privada del NorteUniversidade Estadual Paulista (UNESP)Al-Mustaqbal University CollegeUniversity Medical Center TuebingenCollegium Humanum Warsaw Management UniversityAl-Ouqaili, Mushtak T.S.Saleh, Raed ObaidAmin, Hawraz Ibrahim M.Jawhar, Zanko HassanAkbarizadeh, Majid RezaNaderifar, MahinIssa, Kovan DilawerGavilán, Juan Carlos OroscoNobre, Marcos Augusto Lima [UNESP]Jalil, Abduladheem TurkiAkhavan-Sigari, Reza2023-07-29T13:45:20Z2023-07-29T13:45:20Z2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.arabjc.2023.104704Arabian Journal of Chemistry, v. 16, n. 6, 2023.1878-5352http://hdl.handle.net/11449/24848410.1016/j.arabjc.2023.1047042-s2.0-85149667984Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArabian Journal of Chemistryinfo:eu-repo/semantics/openAccess2024-06-18T18:18:15Zoai:repositorio.unesp.br:11449/248484Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:22:47.028416Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency
title Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency
spellingShingle Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency
Al-Ouqaili, Mushtak T.S.
Anti-microbial effects
Nanovesicle
Pistacia atlantica extract
Pluronic surfactant
title_short Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency
title_full Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency
title_fullStr Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency
title_full_unstemmed Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency
title_sort Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency
author Al-Ouqaili, Mushtak T.S.
author_facet Al-Ouqaili, Mushtak T.S.
Saleh, Raed Obaid
Amin, Hawraz Ibrahim M.
Jawhar, Zanko Hassan
Akbarizadeh, Majid Reza
Naderifar, Mahin
Issa, Kovan Dilawer
Gavilán, Juan Carlos Orosco
Nobre, Marcos Augusto Lima [UNESP]
Jalil, Abduladheem Turki
Akhavan-Sigari, Reza
author_role author
author2 Saleh, Raed Obaid
Amin, Hawraz Ibrahim M.
Jawhar, Zanko Hassan
Akbarizadeh, Majid Reza
Naderifar, Mahin
Issa, Kovan Dilawer
Gavilán, Juan Carlos Orosco
Nobre, Marcos Augusto Lima [UNESP]
Jalil, Abduladheem Turki
Akhavan-Sigari, Reza
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv University of Anbar
Al-Maarif University College
Salahaddin University-Erbil
Cihan University-Erbil
Lebanese French University
Hawler Medical University
Zabol University of Medical Sciences
Tishk International University
Universidad Privada del Norte
Universidade Estadual Paulista (UNESP)
Al-Mustaqbal University College
University Medical Center Tuebingen
Collegium Humanum Warsaw Management University
dc.contributor.author.fl_str_mv Al-Ouqaili, Mushtak T.S.
Saleh, Raed Obaid
Amin, Hawraz Ibrahim M.
Jawhar, Zanko Hassan
Akbarizadeh, Majid Reza
Naderifar, Mahin
Issa, Kovan Dilawer
Gavilán, Juan Carlos Orosco
Nobre, Marcos Augusto Lima [UNESP]
Jalil, Abduladheem Turki
Akhavan-Sigari, Reza
dc.subject.por.fl_str_mv Anti-microbial effects
Nanovesicle
Pistacia atlantica extract
Pluronic surfactant
topic Anti-microbial effects
Nanovesicle
Pistacia atlantica extract
Pluronic surfactant
description One of the current concerns to human health is antibiotic resistance, which promotes the use of antibiotics that are more harmful, expensive, and ineffective. In this condition, researchers are turning to innovative options to combat this alarming situation. Combining herbal medicine with nanotechnology has created a new strategy to increase the effectiveness of phytochemical compounds in overcoming antimicrobial resistance. Pistacia atlantica is one of the promising herbs with medicinal benefits, but its poor solubility in biological fluids is challenging. In this regard, we seek to evaluate the antibacterial efficacy of Pistacia atlantica extract-loaded nanovesicle. Cholesterol, Span 40, and Pluronic F127 modified nanoformulation was developed using an environmentally friendly improved heating technique, and it was evaluated for size distribution, zeta potential, morphology, entrapment efficiency (EE%), release behavior, stability, and antimicrobial performance. By using DLS, spherical nanovesicles were identified with a size distribution of 50–150 nm and a zeta potential of −43 mV. The extract's encapsulation efficiency was 72.03%. The developed loaded nanovesicles demonstrated controlled extract release in the tested 96 h and storage stability of at least 12 months at 25 °C. Also, Comparing the two samples, the encapsulated extract had greater antibacterial activity against Candida albicans, Staphylococcus aureus, and Pseudomonas plecoglossicida with MIC of 1320, 570, and 1100 µg/mL, respectively. Besides reducing the misuse of antibiotics by allowing for the controlled release of drugs made from natural sources, we expect the findings described here to help provide alternative plant-based formulations with greater stability and antibacterial activity.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T13:45:20Z
2023-07-29T13:45:20Z
2023-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.arabjc.2023.104704
Arabian Journal of Chemistry, v. 16, n. 6, 2023.
1878-5352
http://hdl.handle.net/11449/248484
10.1016/j.arabjc.2023.104704
2-s2.0-85149667984
url http://dx.doi.org/10.1016/j.arabjc.2023.104704
http://hdl.handle.net/11449/248484
identifier_str_mv Arabian Journal of Chemistry, v. 16, n. 6, 2023.
1878-5352
10.1016/j.arabjc.2023.104704
2-s2.0-85149667984
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arabian Journal of Chemistry
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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