Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.arabjc.2023.104704 http://hdl.handle.net/11449/248484 |
Resumo: | One of the current concerns to human health is antibiotic resistance, which promotes the use of antibiotics that are more harmful, expensive, and ineffective. In this condition, researchers are turning to innovative options to combat this alarming situation. Combining herbal medicine with nanotechnology has created a new strategy to increase the effectiveness of phytochemical compounds in overcoming antimicrobial resistance. Pistacia atlantica is one of the promising herbs with medicinal benefits, but its poor solubility in biological fluids is challenging. In this regard, we seek to evaluate the antibacterial efficacy of Pistacia atlantica extract-loaded nanovesicle. Cholesterol, Span 40, and Pluronic F127 modified nanoformulation was developed using an environmentally friendly improved heating technique, and it was evaluated for size distribution, zeta potential, morphology, entrapment efficiency (EE%), release behavior, stability, and antimicrobial performance. By using DLS, spherical nanovesicles were identified with a size distribution of 50–150 nm and a zeta potential of −43 mV. The extract's encapsulation efficiency was 72.03%. The developed loaded nanovesicles demonstrated controlled extract release in the tested 96 h and storage stability of at least 12 months at 25 °C. Also, Comparing the two samples, the encapsulated extract had greater antibacterial activity against Candida albicans, Staphylococcus aureus, and Pseudomonas plecoglossicida with MIC of 1320, 570, and 1100 µg/mL, respectively. Besides reducing the misuse of antibiotics by allowing for the controlled release of drugs made from natural sources, we expect the findings described here to help provide alternative plant-based formulations with greater stability and antibacterial activity. |
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Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiencyAnti-microbial effectsNanovesiclePistacia atlantica extractPluronic surfactantOne of the current concerns to human health is antibiotic resistance, which promotes the use of antibiotics that are more harmful, expensive, and ineffective. In this condition, researchers are turning to innovative options to combat this alarming situation. Combining herbal medicine with nanotechnology has created a new strategy to increase the effectiveness of phytochemical compounds in overcoming antimicrobial resistance. Pistacia atlantica is one of the promising herbs with medicinal benefits, but its poor solubility in biological fluids is challenging. In this regard, we seek to evaluate the antibacterial efficacy of Pistacia atlantica extract-loaded nanovesicle. Cholesterol, Span 40, and Pluronic F127 modified nanoformulation was developed using an environmentally friendly improved heating technique, and it was evaluated for size distribution, zeta potential, morphology, entrapment efficiency (EE%), release behavior, stability, and antimicrobial performance. By using DLS, spherical nanovesicles were identified with a size distribution of 50–150 nm and a zeta potential of −43 mV. The extract's encapsulation efficiency was 72.03%. The developed loaded nanovesicles demonstrated controlled extract release in the tested 96 h and storage stability of at least 12 months at 25 °C. Also, Comparing the two samples, the encapsulated extract had greater antibacterial activity against Candida albicans, Staphylococcus aureus, and Pseudomonas plecoglossicida with MIC of 1320, 570, and 1100 µg/mL, respectively. Besides reducing the misuse of antibiotics by allowing for the controlled release of drugs made from natural sources, we expect the findings described here to help provide alternative plant-based formulations with greater stability and antibacterial activity.Department of Microbiology College of Medicine University of Anbar, AnbarDepartment of Medical Laboratory Techniques Al-Maarif University CollegeChemistry Department Salahaddin University-ErbilDepartment of Medical Biochemical Analysis Cihan University-ErbilMedical Laboratory Science Department College of Health Science Lebanese French UniversityClinical Biochemistry Department College of Health Sciences Hawler Medical UniversityAmir Al Momenin Hospital Zabol University of Medical SciencesMedical Analysis Department Applied Science Faculty Tishk International University, Kurdistan RegionUniversidad Privada del Norte, Campus VirtualDepartment of Physics School of Technology and Sciences Sao Paulo State University – UNESP Presidente Prudente BrazilMedical Laboratories Techniques Department Al-Mustaqbal University College, BabylonDepartment of Neurosurgery University Medical Center TuebingenDepartment of Health Care Management and Clinical Research Collegium Humanum Warsaw Management UniversityDepartment of Physics School of Technology and Sciences Sao Paulo State University – UNESP Presidente Prudente BrazilUniversity of AnbarAl-Maarif University CollegeSalahaddin University-ErbilCihan University-ErbilLebanese French UniversityHawler Medical UniversityZabol University of Medical SciencesTishk International UniversityUniversidad Privada del NorteUniversidade Estadual Paulista (UNESP)Al-Mustaqbal University CollegeUniversity Medical Center TuebingenCollegium Humanum Warsaw Management UniversityAl-Ouqaili, Mushtak T.S.Saleh, Raed ObaidAmin, Hawraz Ibrahim M.Jawhar, Zanko HassanAkbarizadeh, Majid RezaNaderifar, MahinIssa, Kovan DilawerGavilán, Juan Carlos OroscoNobre, Marcos Augusto Lima [UNESP]Jalil, Abduladheem TurkiAkhavan-Sigari, Reza2023-07-29T13:45:20Z2023-07-29T13:45:20Z2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.arabjc.2023.104704Arabian Journal of Chemistry, v. 16, n. 6, 2023.1878-5352http://hdl.handle.net/11449/24848410.1016/j.arabjc.2023.1047042-s2.0-85149667984Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArabian Journal of Chemistryinfo:eu-repo/semantics/openAccess2024-06-18T18:18:15Zoai:repositorio.unesp.br:11449/248484Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:22:47.028416Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency |
title |
Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency |
spellingShingle |
Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency Al-Ouqaili, Mushtak T.S. Anti-microbial effects Nanovesicle Pistacia atlantica extract Pluronic surfactant |
title_short |
Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency |
title_full |
Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency |
title_fullStr |
Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency |
title_full_unstemmed |
Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency |
title_sort |
Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency |
author |
Al-Ouqaili, Mushtak T.S. |
author_facet |
Al-Ouqaili, Mushtak T.S. Saleh, Raed Obaid Amin, Hawraz Ibrahim M. Jawhar, Zanko Hassan Akbarizadeh, Majid Reza Naderifar, Mahin Issa, Kovan Dilawer Gavilán, Juan Carlos Orosco Nobre, Marcos Augusto Lima [UNESP] Jalil, Abduladheem Turki Akhavan-Sigari, Reza |
author_role |
author |
author2 |
Saleh, Raed Obaid Amin, Hawraz Ibrahim M. Jawhar, Zanko Hassan Akbarizadeh, Majid Reza Naderifar, Mahin Issa, Kovan Dilawer Gavilán, Juan Carlos Orosco Nobre, Marcos Augusto Lima [UNESP] Jalil, Abduladheem Turki Akhavan-Sigari, Reza |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
University of Anbar Al-Maarif University College Salahaddin University-Erbil Cihan University-Erbil Lebanese French University Hawler Medical University Zabol University of Medical Sciences Tishk International University Universidad Privada del Norte Universidade Estadual Paulista (UNESP) Al-Mustaqbal University College University Medical Center Tuebingen Collegium Humanum Warsaw Management University |
dc.contributor.author.fl_str_mv |
Al-Ouqaili, Mushtak T.S. Saleh, Raed Obaid Amin, Hawraz Ibrahim M. Jawhar, Zanko Hassan Akbarizadeh, Majid Reza Naderifar, Mahin Issa, Kovan Dilawer Gavilán, Juan Carlos Orosco Nobre, Marcos Augusto Lima [UNESP] Jalil, Abduladheem Turki Akhavan-Sigari, Reza |
dc.subject.por.fl_str_mv |
Anti-microbial effects Nanovesicle Pistacia atlantica extract Pluronic surfactant |
topic |
Anti-microbial effects Nanovesicle Pistacia atlantica extract Pluronic surfactant |
description |
One of the current concerns to human health is antibiotic resistance, which promotes the use of antibiotics that are more harmful, expensive, and ineffective. In this condition, researchers are turning to innovative options to combat this alarming situation. Combining herbal medicine with nanotechnology has created a new strategy to increase the effectiveness of phytochemical compounds in overcoming antimicrobial resistance. Pistacia atlantica is one of the promising herbs with medicinal benefits, but its poor solubility in biological fluids is challenging. In this regard, we seek to evaluate the antibacterial efficacy of Pistacia atlantica extract-loaded nanovesicle. Cholesterol, Span 40, and Pluronic F127 modified nanoformulation was developed using an environmentally friendly improved heating technique, and it was evaluated for size distribution, zeta potential, morphology, entrapment efficiency (EE%), release behavior, stability, and antimicrobial performance. By using DLS, spherical nanovesicles were identified with a size distribution of 50–150 nm and a zeta potential of −43 mV. The extract's encapsulation efficiency was 72.03%. The developed loaded nanovesicles demonstrated controlled extract release in the tested 96 h and storage stability of at least 12 months at 25 °C. Also, Comparing the two samples, the encapsulated extract had greater antibacterial activity against Candida albicans, Staphylococcus aureus, and Pseudomonas plecoglossicida with MIC of 1320, 570, and 1100 µg/mL, respectively. Besides reducing the misuse of antibiotics by allowing for the controlled release of drugs made from natural sources, we expect the findings described here to help provide alternative plant-based formulations with greater stability and antibacterial activity. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:45:20Z 2023-07-29T13:45:20Z 2023-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.arabjc.2023.104704 Arabian Journal of Chemistry, v. 16, n. 6, 2023. 1878-5352 http://hdl.handle.net/11449/248484 10.1016/j.arabjc.2023.104704 2-s2.0-85149667984 |
url |
http://dx.doi.org/10.1016/j.arabjc.2023.104704 http://hdl.handle.net/11449/248484 |
identifier_str_mv |
Arabian Journal of Chemistry, v. 16, n. 6, 2023. 1878-5352 10.1016/j.arabjc.2023.104704 2-s2.0-85149667984 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arabian Journal of Chemistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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_version_ |
1808129195304288256 |