N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4322/rbeb.2013.019 http://hdl.handle.net/11449/76008 |
Resumo: | Introduction: The ability of staphylococci to produce biofilm is an important virulence mechanism that allows bacteria both to adhere and to live on artificial surfaces and to resist to the host immune factors and antibiotics. Staphylococcal infections have become increasingly difficult to treat due their antibiotic resistance. Therefore, there is a continuous need for new and effective treatment alternatives against staphylococcal infections. The main goal of this study was to test N-acetylcysteine (NAC) and vancomycin alone and in combination against S. epidermidis and S. aureus biofilms. Methods: Biofilms were treated with NAC at minimum inhibitory concentration (MIC) and 10 × MIC concentrations and vancomycin at MIC and peak serum concentrations. Results: The use of NAC 10 × MIC alone showed a significant antibactericidal effect, promoting a 4-5 log10 CFU/ mL reduction in biofilm cells. The combination of NAC 10 × MIC with vancomycin (independently of the concentration used) reduced significantly the number of biofilm cells for all strains evaluated (5-6 log10). Conclusion: N-acetylcysteine associated to vancomycin can be a potential therapeutic strategy in the treatment of infections associated to biofilms of S. epidermidis or S. aureus. |
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Repositório Institucional da UNESP |
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N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilmBiofilmN-acetylcysteineStaphylococcus aureusStaphylococcus epidermidisVancomycinAntibiotic resistanceArtificial surfacesMinimum inhibitory concentrationTherapeutic strategyAntibioticsBacteriaEnzyme inhibitionBiofilmsIntroduction: The ability of staphylococci to produce biofilm is an important virulence mechanism that allows bacteria both to adhere and to live on artificial surfaces and to resist to the host immune factors and antibiotics. Staphylococcal infections have become increasingly difficult to treat due their antibiotic resistance. Therefore, there is a continuous need for new and effective treatment alternatives against staphylococcal infections. The main goal of this study was to test N-acetylcysteine (NAC) and vancomycin alone and in combination against S. epidermidis and S. aureus biofilms. Methods: Biofilms were treated with NAC at minimum inhibitory concentration (MIC) and 10 × MIC concentrations and vancomycin at MIC and peak serum concentrations. Results: The use of NAC 10 × MIC alone showed a significant antibactericidal effect, promoting a 4-5 log10 CFU/ mL reduction in biofilm cells. The combination of NAC 10 × MIC with vancomycin (independently of the concentration used) reduced significantly the number of biofilm cells for all strains evaluated (5-6 log10). Conclusion: N-acetylcysteine associated to vancomycin can be a potential therapeutic strategy in the treatment of infections associated to biofilms of S. epidermidis or S. aureus.Department of Biotechnology Federal University of São Carlos - UFSCar, Rodovia Washington Luis, Km 235, CEP 13560-000, São Carlos, SPInstitute for Biotechnology and Bioengineering - IBB University of Minho, BragaSão Paulo State University - USP, Jaboticabal, SPSão Paulo State University - UNESP, Rua Expedicionários do Brasil, 1621, CEP 14801-360, Araraquara, SPSão Paulo State University - USP, Jaboticabal, SPSão Paulo State University - UNESP, Rua Expedicionários do Brasil, 1621, CEP 14801-360, Araraquara, SPUniversidade Federal de São Carlos (UFSCar)University of MinhoUniversidade Estadual Paulista (Unesp)Leite, BrunaGomes, FernandaMelo, Poliana [UNESP]Souza, ClovisTeixeira, PilarOliveira, RosárioPizzolitto, Elisabeth [UNESP]2014-05-27T11:29:58Z2014-05-27T11:29:58Z2013-07-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article184-192application/pdfhttp://dx.doi.org/10.4322/rbeb.2013.019Revista Brasileira de Engenharia Biomedica, v. 29, n. 2, p. 184-192, 2013.1517-31511984-7742http://hdl.handle.net/11449/7600810.4322/rbeb.2013.0192-s2.0-848800947092-s2.0-84880094709.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Engenharia Biomédica0,179info:eu-repo/semantics/openAccess2024-06-21T15:19:09Zoai:repositorio.unesp.br:11449/76008Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:33:03.729015Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm |
title |
N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm |
spellingShingle |
N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm Leite, Bruna Biofilm N-acetylcysteine Staphylococcus aureus Staphylococcus epidermidis Vancomycin Antibiotic resistance Artificial surfaces Minimum inhibitory concentration Therapeutic strategy Antibiotics Bacteria Enzyme inhibition Biofilms |
title_short |
N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm |
title_full |
N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm |
title_fullStr |
N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm |
title_full_unstemmed |
N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm |
title_sort |
N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm |
author |
Leite, Bruna |
author_facet |
Leite, Bruna Gomes, Fernanda Melo, Poliana [UNESP] Souza, Clovis Teixeira, Pilar Oliveira, Rosário Pizzolitto, Elisabeth [UNESP] |
author_role |
author |
author2 |
Gomes, Fernanda Melo, Poliana [UNESP] Souza, Clovis Teixeira, Pilar Oliveira, Rosário Pizzolitto, Elisabeth [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) University of Minho Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Leite, Bruna Gomes, Fernanda Melo, Poliana [UNESP] Souza, Clovis Teixeira, Pilar Oliveira, Rosário Pizzolitto, Elisabeth [UNESP] |
dc.subject.por.fl_str_mv |
Biofilm N-acetylcysteine Staphylococcus aureus Staphylococcus epidermidis Vancomycin Antibiotic resistance Artificial surfaces Minimum inhibitory concentration Therapeutic strategy Antibiotics Bacteria Enzyme inhibition Biofilms |
topic |
Biofilm N-acetylcysteine Staphylococcus aureus Staphylococcus epidermidis Vancomycin Antibiotic resistance Artificial surfaces Minimum inhibitory concentration Therapeutic strategy Antibiotics Bacteria Enzyme inhibition Biofilms |
description |
Introduction: The ability of staphylococci to produce biofilm is an important virulence mechanism that allows bacteria both to adhere and to live on artificial surfaces and to resist to the host immune factors and antibiotics. Staphylococcal infections have become increasingly difficult to treat due their antibiotic resistance. Therefore, there is a continuous need for new and effective treatment alternatives against staphylococcal infections. The main goal of this study was to test N-acetylcysteine (NAC) and vancomycin alone and in combination against S. epidermidis and S. aureus biofilms. Methods: Biofilms were treated with NAC at minimum inhibitory concentration (MIC) and 10 × MIC concentrations and vancomycin at MIC and peak serum concentrations. Results: The use of NAC 10 × MIC alone showed a significant antibactericidal effect, promoting a 4-5 log10 CFU/ mL reduction in biofilm cells. The combination of NAC 10 × MIC with vancomycin (independently of the concentration used) reduced significantly the number of biofilm cells for all strains evaluated (5-6 log10). Conclusion: N-acetylcysteine associated to vancomycin can be a potential therapeutic strategy in the treatment of infections associated to biofilms of S. epidermidis or S. aureus. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-07-18 2014-05-27T11:29:58Z 2014-05-27T11:29:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4322/rbeb.2013.019 Revista Brasileira de Engenharia Biomedica, v. 29, n. 2, p. 184-192, 2013. 1517-3151 1984-7742 http://hdl.handle.net/11449/76008 10.4322/rbeb.2013.019 2-s2.0-84880094709 2-s2.0-84880094709.pdf |
url |
http://dx.doi.org/10.4322/rbeb.2013.019 http://hdl.handle.net/11449/76008 |
identifier_str_mv |
Revista Brasileira de Engenharia Biomedica, v. 29, n. 2, p. 184-192, 2013. 1517-3151 1984-7742 10.4322/rbeb.2013.019 2-s2.0-84880094709 2-s2.0-84880094709.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Engenharia Biomédica 0,179 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
184-192 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129219401613312 |