Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2016/7154524 http://hdl.handle.net/11449/173039 |
Resumo: | The present study characterized natural killer cells and cytokines in diabetic mothers, their placenta, and fetus. In the maternal blood from the hyperglycemic groups, the CD16+CD56- NK cells increased, whereas that of CD16+CD56+ decreased in gestational diabetes mellitus [GDM] group. Cord blood from type 2 diabetes [DM-2] showed a higher proportion of CD16+CD56- and CD16-CD56+. The placental extravillous layer of GDM and DM-2 showed an increase of CD16+CD56- cells and, irrespective of region, the proportion of CD16-CD56+ cells was higher in mild gestational hyperglycemia [MGH] and GDM and lower in DM-2. IL-2 was lower in maternal blood and IFN-γ higher in maternal and cord blood from the GDM group. IL-17 was higher in maternal and cord blood from the DM-2 group. The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-γ and low levels of IL-1β and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-γ. The GDM group, irrespective of region, showed higher levels of IL-8. The DM-2 group, irrespective of region, placenta showed high levels of TNF-α, IL-17, and IFN-γ. The hyperglycemia produces an inflammatory environment with a high content of inflammatory cytokines and cells expressing CD16+. |
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Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic MothersThe present study characterized natural killer cells and cytokines in diabetic mothers, their placenta, and fetus. In the maternal blood from the hyperglycemic groups, the CD16+CD56- NK cells increased, whereas that of CD16+CD56+ decreased in gestational diabetes mellitus [GDM] group. Cord blood from type 2 diabetes [DM-2] showed a higher proportion of CD16+CD56- and CD16-CD56+. The placental extravillous layer of GDM and DM-2 showed an increase of CD16+CD56- cells and, irrespective of region, the proportion of CD16-CD56+ cells was higher in mild gestational hyperglycemia [MGH] and GDM and lower in DM-2. IL-2 was lower in maternal blood and IFN-γ higher in maternal and cord blood from the GDM group. IL-17 was higher in maternal and cord blood from the DM-2 group. The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-γ and low levels of IL-1β and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-γ. The GDM group, irrespective of region, showed higher levels of IL-8. The DM-2 group, irrespective of region, placenta showed high levels of TNF-α, IL-17, and IFN-γ. The hyperglycemia produces an inflammatory environment with a high content of inflammatory cytokines and cells expressing CD16+.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Graduate Program in Gynecology Obstetrics and Mastology Botucatu Medical School S�o Paulo State University (UNESP)Institute of Biological and Health Science Federal University of Mato GrossoGraduate Program in Gynecology Obstetrics and Mastology Botucatu Medical School S�o Paulo State University (UNESP)FAPESP: 2012/24212-4FAPESP: 2013/13017-9Universidade Estadual Paulista (Unesp)Federal University of Mato GrossoHara, Cristiane De Castro Pernet [UNESP]Fran�a, Eduardo Luz�aFagundes, Danny Laura GomesDe Queiroz, Adriele AtaidesRudge, Marilza Vieira Cunha [UNESP]Honorio-Fran�a, Adenilda CristinaCalderon, Iracema De Mattos Paranhos [UNESP]2018-12-11T17:03:14Z2018-12-11T17:03:14Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2016/7154524Journal of Immunology Research, v. 2016.2314-71562314-8861http://hdl.handle.net/11449/17303910.1155/2016/71545242-s2.0-849731248682-s2.0-84973124868.pdf6758680388835078Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Immunology Research1,3521,352info:eu-repo/semantics/openAccess2024-08-16T14:06:54Zoai:repositorio.unesp.br:11449/173039Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:06:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers |
title |
Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers |
spellingShingle |
Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers Hara, Cristiane De Castro Pernet [UNESP] |
title_short |
Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers |
title_full |
Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers |
title_fullStr |
Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers |
title_full_unstemmed |
Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers |
title_sort |
Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers |
author |
Hara, Cristiane De Castro Pernet [UNESP] |
author_facet |
Hara, Cristiane De Castro Pernet [UNESP] Fran�a, Eduardo Luz�a Fagundes, Danny Laura Gomes De Queiroz, Adriele Ataides Rudge, Marilza Vieira Cunha [UNESP] Honorio-Fran�a, Adenilda Cristina Calderon, Iracema De Mattos Paranhos [UNESP] |
author_role |
author |
author2 |
Fran�a, Eduardo Luz�a Fagundes, Danny Laura Gomes De Queiroz, Adriele Ataides Rudge, Marilza Vieira Cunha [UNESP] Honorio-Fran�a, Adenilda Cristina Calderon, Iracema De Mattos Paranhos [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Federal University of Mato Grosso |
dc.contributor.author.fl_str_mv |
Hara, Cristiane De Castro Pernet [UNESP] Fran�a, Eduardo Luz�a Fagundes, Danny Laura Gomes De Queiroz, Adriele Ataides Rudge, Marilza Vieira Cunha [UNESP] Honorio-Fran�a, Adenilda Cristina Calderon, Iracema De Mattos Paranhos [UNESP] |
description |
The present study characterized natural killer cells and cytokines in diabetic mothers, their placenta, and fetus. In the maternal blood from the hyperglycemic groups, the CD16+CD56- NK cells increased, whereas that of CD16+CD56+ decreased in gestational diabetes mellitus [GDM] group. Cord blood from type 2 diabetes [DM-2] showed a higher proportion of CD16+CD56- and CD16-CD56+. The placental extravillous layer of GDM and DM-2 showed an increase of CD16+CD56- cells and, irrespective of region, the proportion of CD16-CD56+ cells was higher in mild gestational hyperglycemia [MGH] and GDM and lower in DM-2. IL-2 was lower in maternal blood and IFN-γ higher in maternal and cord blood from the GDM group. IL-17 was higher in maternal and cord blood from the DM-2 group. The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-γ and low levels of IL-1β and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-γ. The GDM group, irrespective of region, showed higher levels of IL-8. The DM-2 group, irrespective of region, placenta showed high levels of TNF-α, IL-17, and IFN-γ. The hyperglycemia produces an inflammatory environment with a high content of inflammatory cytokines and cells expressing CD16+. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2018-12-11T17:03:14Z 2018-12-11T17:03:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2016/7154524 Journal of Immunology Research, v. 2016. 2314-7156 2314-8861 http://hdl.handle.net/11449/173039 10.1155/2016/7154524 2-s2.0-84973124868 2-s2.0-84973124868.pdf 6758680388835078 |
url |
http://dx.doi.org/10.1155/2016/7154524 http://hdl.handle.net/11449/173039 |
identifier_str_mv |
Journal of Immunology Research, v. 2016. 2314-7156 2314-8861 10.1155/2016/7154524 2-s2.0-84973124868 2-s2.0-84973124868.pdf 6758680388835078 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Immunology Research 1,352 1,352 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128138731847680 |