Centrally acting antihypertensives change the psychogenic cardiovascular reactivity
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/fcp.12648 http://hdl.handle.net/11449/208462 |
Resumo: | Clonidine (CL) and Rilmenidine (RI) are among the most frequently prescribed centrally acting antihypertensives. Here, we compared CL and RI effects on psychogenic cardiovascular reactivity to sonant, luminous, motosensory, and vibrotactile stimuli during neurogenic hypertension. The femoral artery and vein of Wistar (WT – normotensive) and spontaneously hypertensive rats (SHR) were catheterized before (24 h interval) i.p. injection of vehicle (NaCl 0.9%, control - CT group), CL (10 µg/kg), or RI (10 µg/kg) and acute exposure to luminous (5000 lm), sonant (75 dB sudden tap), motor (180° cage twist), and air-jet (10 L/min – restraint and vibrotactile). Findings showed that: (i) CL or RI reduced the arterial pressure of SHR, without affecting basal heart rate in WT and SHR; (ii) different stimuli evoked pressor and tachycardic responses; (iii) CL and RI reduced pressor response to sound; (iv) CL or RI reduced pressor responses to luminous stimulus without a change in peak tachycardia in SHR; (v) cage twist increased blood pressure in SHR, which was attenuated by CL or RI; (vi) air-jet increased pressure and heart rate; (vii) CL or RI attenuated the pressor responses to air-jet in SHR while RI reduced the chronotropic reactivity in both strains. Altogether, both antihypertensives relieved the psychogenic cardiovascular responses to different stimuli. The RI elicited higher cardioprotective effects through a reduction in air-jet-induced tachycardia. |
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Centrally acting antihypertensives change the psychogenic cardiovascular reactivityarousaldefense reactionsheart ratehypertensionstressClonidine (CL) and Rilmenidine (RI) are among the most frequently prescribed centrally acting antihypertensives. Here, we compared CL and RI effects on psychogenic cardiovascular reactivity to sonant, luminous, motosensory, and vibrotactile stimuli during neurogenic hypertension. The femoral artery and vein of Wistar (WT – normotensive) and spontaneously hypertensive rats (SHR) were catheterized before (24 h interval) i.p. injection of vehicle (NaCl 0.9%, control - CT group), CL (10 µg/kg), or RI (10 µg/kg) and acute exposure to luminous (5000 lm), sonant (75 dB sudden tap), motor (180° cage twist), and air-jet (10 L/min – restraint and vibrotactile). Findings showed that: (i) CL or RI reduced the arterial pressure of SHR, without affecting basal heart rate in WT and SHR; (ii) different stimuli evoked pressor and tachycardic responses; (iii) CL and RI reduced pressor response to sound; (iv) CL or RI reduced pressor responses to luminous stimulus without a change in peak tachycardia in SHR; (v) cage twist increased blood pressure in SHR, which was attenuated by CL or RI; (vi) air-jet increased pressure and heart rate; (vii) CL or RI attenuated the pressor responses to air-jet in SHR while RI reduced the chronotropic reactivity in both strains. Altogether, both antihypertensives relieved the psychogenic cardiovascular responses to different stimuli. The RI elicited higher cardioprotective effects through a reduction in air-jet-induced tachycardia.Institute of Biological Sciences Federal University of GoiasSchool of Medicine Federal University of GoiasInstitute of Biomedical Sciences Federal University of UberlandiaInstitute of Biological Sciences Federal University of Minas GeraisSchool of Dentistry São Paulo State University (UNESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)School of Dentistry São Paulo State University (UNESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Federal University of GoiasUniversidade Federal de Uberlândia (UFU)Universidade Federal de Minas Gerais (UFMG)Universidade Estadual Paulista (Unesp)Mendonça, Michelle M.Costa, Amanda N.Moraes, Gean C.A.Martins, Gustavo M.Almeida, Aline F.Rincon, Gabriel C.N.Siqueira, João P.R.Padilha, Daniella M.Moya, Marcela I.Ferreira-Neto, Marcos L.Gomes, Rodrigo MelloPedrino, Gustavo RodriguesFontes, Marco Antônio PelikyColombari, Eduardo [UNESP]Crestani, Carlos C. [UNESP]Fajemiroye, James O.Xavier, Carlos Henrique2021-06-25T11:12:32Z2021-06-25T11:12:32Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1111/fcp.12648Fundamental and Clinical Pharmacology.1472-82060767-3981http://hdl.handle.net/11449/20846210.1111/fcp.126482-s2.0-85101770967Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFundamental and Clinical Pharmacologyinfo:eu-repo/semantics/openAccess2021-10-23T19:02:12Zoai:repositorio.unesp.br:11449/208462Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:02:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Centrally acting antihypertensives change the psychogenic cardiovascular reactivity |
title |
Centrally acting antihypertensives change the psychogenic cardiovascular reactivity |
spellingShingle |
Centrally acting antihypertensives change the psychogenic cardiovascular reactivity Mendonça, Michelle M. arousal defense reactions heart rate hypertension stress |
title_short |
Centrally acting antihypertensives change the psychogenic cardiovascular reactivity |
title_full |
Centrally acting antihypertensives change the psychogenic cardiovascular reactivity |
title_fullStr |
Centrally acting antihypertensives change the psychogenic cardiovascular reactivity |
title_full_unstemmed |
Centrally acting antihypertensives change the psychogenic cardiovascular reactivity |
title_sort |
Centrally acting antihypertensives change the psychogenic cardiovascular reactivity |
author |
Mendonça, Michelle M. |
author_facet |
Mendonça, Michelle M. Costa, Amanda N. Moraes, Gean C.A. Martins, Gustavo M. Almeida, Aline F. Rincon, Gabriel C.N. Siqueira, João P.R. Padilha, Daniella M. Moya, Marcela I. Ferreira-Neto, Marcos L. Gomes, Rodrigo Mello Pedrino, Gustavo Rodrigues Fontes, Marco Antônio Peliky Colombari, Eduardo [UNESP] Crestani, Carlos C. [UNESP] Fajemiroye, James O. Xavier, Carlos Henrique |
author_role |
author |
author2 |
Costa, Amanda N. Moraes, Gean C.A. Martins, Gustavo M. Almeida, Aline F. Rincon, Gabriel C.N. Siqueira, João P.R. Padilha, Daniella M. Moya, Marcela I. Ferreira-Neto, Marcos L. Gomes, Rodrigo Mello Pedrino, Gustavo Rodrigues Fontes, Marco Antônio Peliky Colombari, Eduardo [UNESP] Crestani, Carlos C. [UNESP] Fajemiroye, James O. Xavier, Carlos Henrique |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Federal University of Goias Universidade Federal de Uberlândia (UFU) Universidade Federal de Minas Gerais (UFMG) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Mendonça, Michelle M. Costa, Amanda N. Moraes, Gean C.A. Martins, Gustavo M. Almeida, Aline F. Rincon, Gabriel C.N. Siqueira, João P.R. Padilha, Daniella M. Moya, Marcela I. Ferreira-Neto, Marcos L. Gomes, Rodrigo Mello Pedrino, Gustavo Rodrigues Fontes, Marco Antônio Peliky Colombari, Eduardo [UNESP] Crestani, Carlos C. [UNESP] Fajemiroye, James O. Xavier, Carlos Henrique |
dc.subject.por.fl_str_mv |
arousal defense reactions heart rate hypertension stress |
topic |
arousal defense reactions heart rate hypertension stress |
description |
Clonidine (CL) and Rilmenidine (RI) are among the most frequently prescribed centrally acting antihypertensives. Here, we compared CL and RI effects on psychogenic cardiovascular reactivity to sonant, luminous, motosensory, and vibrotactile stimuli during neurogenic hypertension. The femoral artery and vein of Wistar (WT – normotensive) and spontaneously hypertensive rats (SHR) were catheterized before (24 h interval) i.p. injection of vehicle (NaCl 0.9%, control - CT group), CL (10 µg/kg), or RI (10 µg/kg) and acute exposure to luminous (5000 lm), sonant (75 dB sudden tap), motor (180° cage twist), and air-jet (10 L/min – restraint and vibrotactile). Findings showed that: (i) CL or RI reduced the arterial pressure of SHR, without affecting basal heart rate in WT and SHR; (ii) different stimuli evoked pressor and tachycardic responses; (iii) CL and RI reduced pressor response to sound; (iv) CL or RI reduced pressor responses to luminous stimulus without a change in peak tachycardia in SHR; (v) cage twist increased blood pressure in SHR, which was attenuated by CL or RI; (vi) air-jet increased pressure and heart rate; (vii) CL or RI attenuated the pressor responses to air-jet in SHR while RI reduced the chronotropic reactivity in both strains. Altogether, both antihypertensives relieved the psychogenic cardiovascular responses to different stimuli. The RI elicited higher cardioprotective effects through a reduction in air-jet-induced tachycardia. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:12:32Z 2021-06-25T11:12:32Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/fcp.12648 Fundamental and Clinical Pharmacology. 1472-8206 0767-3981 http://hdl.handle.net/11449/208462 10.1111/fcp.12648 2-s2.0-85101770967 |
url |
http://dx.doi.org/10.1111/fcp.12648 http://hdl.handle.net/11449/208462 |
identifier_str_mv |
Fundamental and Clinical Pharmacology. 1472-8206 0767-3981 10.1111/fcp.12648 2-s2.0-85101770967 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Fundamental and Clinical Pharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965222736232448 |