Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0004-282X-ANP-2021-0153 http://hdl.handle.net/11449/241489 |
Resumo: | Background: Intrinsic changes in Parkinson’s disease (PD) affect the autonomic nervous system, and the disease course can aggravate the initial condition. Although the impact of time since disease onset on autonomic modulation has already been studied in other populations, this has not yet been investigated in PD. Objective: To investigate the impact of the length of time since diagnosis on the cardiac autonomic modulation of individuals with PD and compare with healthy individuals. Methods: Fifty participants were divided into three groups: a control group (CG; n = 24) and two groups with PD, divided according to the median length of time since diagnosis (median = 5.5 years): below the median (PG1; n = 13) and above the median (PG2; n = 13). To evaluate cardiac autonomic modulation, heart rate was obtained beat-to-beat in the supine position over a 30-min period, and heart rate variability (HRV) indices were calculated using linear methods in the time and frequency domains. Results: There were no significant differences in HRV indices between the PG groups, or between the three groups regarding Mean RR, LFun, HFun and LF/HF ratio. Significant reductions in the RMSSD, SDNN, pNN50, LFms2 and HFms2 indices were observed in PG1 and PG2, compared with CG. Conclusions: The cardiac autonomic modulation of individuals with PD was not influenced by the time since diagnosis. However, reduced parasympathetic and global modulation were observed in these individuals, compared with controls. These results emphasize the importance of aerobic exercise for improving autonomic modulation among individuals with PD. |
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Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional studyO tempo de diagnóstico na doença de Parkinson influencia a variabilidade da frequência cardíaca? Um estudo transversalAutonomic Nervous System DiseasesNeurodegenerative DiseasesParkinson DiseaseBackground: Intrinsic changes in Parkinson’s disease (PD) affect the autonomic nervous system, and the disease course can aggravate the initial condition. Although the impact of time since disease onset on autonomic modulation has already been studied in other populations, this has not yet been investigated in PD. Objective: To investigate the impact of the length of time since diagnosis on the cardiac autonomic modulation of individuals with PD and compare with healthy individuals. Methods: Fifty participants were divided into three groups: a control group (CG; n = 24) and two groups with PD, divided according to the median length of time since diagnosis (median = 5.5 years): below the median (PG1; n = 13) and above the median (PG2; n = 13). To evaluate cardiac autonomic modulation, heart rate was obtained beat-to-beat in the supine position over a 30-min period, and heart rate variability (HRV) indices were calculated using linear methods in the time and frequency domains. Results: There were no significant differences in HRV indices between the PG groups, or between the three groups regarding Mean RR, LFun, HFun and LF/HF ratio. Significant reductions in the RMSSD, SDNN, pNN50, LFms2 and HFms2 indices were observed in PG1 and PG2, compared with CG. Conclusions: The cardiac autonomic modulation of individuals with PD was not influenced by the time since diagnosis. However, reduced parasympathetic and global modulation were observed in these individuals, compared with controls. These results emphasize the importance of aerobic exercise for improving autonomic modulation among individuals with PD.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Ciências e Tecnologia Departamento de Fisioterapia, SPUniversity Health Network Toronto Rehabilitation InstituteUniversidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Ciências e Tecnologia Departamento de Fisioterapia, SPUniversidade Estadual Paulista (UNESP)Toronto Rehabilitation InstituteStoco-Oliveira, Mileide Cristina [UNESP]Valente, Heloisa Balotari [UNESP]Vanzella, Laís ManataAndré, Larissa Borba [UNESP]Rodrigues, Mariana Viana [UNESP]Vanderlei, Franciele Marques [UNESP]Carvalho, Augusto Cesinando de [UNESP]Vanderlei, Luiz Carlos Marques [UNESP]2023-03-01T21:06:06Z2023-03-01T21:06:06Z2022-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article593-600http://dx.doi.org/10.1590/0004-282X-ANP-2021-0153Arquivos de Neuro-Psiquiatria, v. 80, n. 6, p. 593-600, 2022.1678-42270004-282Xhttp://hdl.handle.net/11449/24148910.1590/0004-282X-ANP-2021-01532-s2.0-85135768118Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccess2024-06-18T18:44:14Zoai:repositorio.unesp.br:11449/241489Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:35:08.089844Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study O tempo de diagnóstico na doença de Parkinson influencia a variabilidade da frequência cardíaca? Um estudo transversal |
title |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
spellingShingle |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study Stoco-Oliveira, Mileide Cristina [UNESP] Autonomic Nervous System Diseases Neurodegenerative Diseases Parkinson Disease |
title_short |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_full |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_fullStr |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_full_unstemmed |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_sort |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
author |
Stoco-Oliveira, Mileide Cristina [UNESP] |
author_facet |
Stoco-Oliveira, Mileide Cristina [UNESP] Valente, Heloisa Balotari [UNESP] Vanzella, Laís Manata André, Larissa Borba [UNESP] Rodrigues, Mariana Viana [UNESP] Vanderlei, Franciele Marques [UNESP] Carvalho, Augusto Cesinando de [UNESP] Vanderlei, Luiz Carlos Marques [UNESP] |
author_role |
author |
author2 |
Valente, Heloisa Balotari [UNESP] Vanzella, Laís Manata André, Larissa Borba [UNESP] Rodrigues, Mariana Viana [UNESP] Vanderlei, Franciele Marques [UNESP] Carvalho, Augusto Cesinando de [UNESP] Vanderlei, Luiz Carlos Marques [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Toronto Rehabilitation Institute |
dc.contributor.author.fl_str_mv |
Stoco-Oliveira, Mileide Cristina [UNESP] Valente, Heloisa Balotari [UNESP] Vanzella, Laís Manata André, Larissa Borba [UNESP] Rodrigues, Mariana Viana [UNESP] Vanderlei, Franciele Marques [UNESP] Carvalho, Augusto Cesinando de [UNESP] Vanderlei, Luiz Carlos Marques [UNESP] |
dc.subject.por.fl_str_mv |
Autonomic Nervous System Diseases Neurodegenerative Diseases Parkinson Disease |
topic |
Autonomic Nervous System Diseases Neurodegenerative Diseases Parkinson Disease |
description |
Background: Intrinsic changes in Parkinson’s disease (PD) affect the autonomic nervous system, and the disease course can aggravate the initial condition. Although the impact of time since disease onset on autonomic modulation has already been studied in other populations, this has not yet been investigated in PD. Objective: To investigate the impact of the length of time since diagnosis on the cardiac autonomic modulation of individuals with PD and compare with healthy individuals. Methods: Fifty participants were divided into three groups: a control group (CG; n = 24) and two groups with PD, divided according to the median length of time since diagnosis (median = 5.5 years): below the median (PG1; n = 13) and above the median (PG2; n = 13). To evaluate cardiac autonomic modulation, heart rate was obtained beat-to-beat in the supine position over a 30-min period, and heart rate variability (HRV) indices were calculated using linear methods in the time and frequency domains. Results: There were no significant differences in HRV indices between the PG groups, or between the three groups regarding Mean RR, LFun, HFun and LF/HF ratio. Significant reductions in the RMSSD, SDNN, pNN50, LFms2 and HFms2 indices were observed in PG1 and PG2, compared with CG. Conclusions: The cardiac autonomic modulation of individuals with PD was not influenced by the time since diagnosis. However, reduced parasympathetic and global modulation were observed in these individuals, compared with controls. These results emphasize the importance of aerobic exercise for improving autonomic modulation among individuals with PD. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-01 2023-03-01T21:06:06Z 2023-03-01T21:06:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0004-282X-ANP-2021-0153 Arquivos de Neuro-Psiquiatria, v. 80, n. 6, p. 593-600, 2022. 1678-4227 0004-282X http://hdl.handle.net/11449/241489 10.1590/0004-282X-ANP-2021-0153 2-s2.0-85135768118 |
url |
http://dx.doi.org/10.1590/0004-282X-ANP-2021-0153 http://hdl.handle.net/11449/241489 |
identifier_str_mv |
Arquivos de Neuro-Psiquiatria, v. 80, n. 6, p. 593-600, 2022. 1678-4227 0004-282X 10.1590/0004-282X-ANP-2021-0153 2-s2.0-85135768118 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
593-600 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129089986363392 |