Parkinson's disease effect on autonomic modulation: an analysis using geometric indices

• Autor(a) principal: Stoco-Oliveira, Mileide Cristina [UNESP]
• Data de Publicação: 2021
• Outros Autores: Ricci-Vitor, Ana Laura [UNESP], Vanzella, Lais Manata [UNESP], Valente, Heloisa Balotari [UNESP], Santos Silva, Vitor Eduardo dos [UNESP], Andre, Larissa Borba [UNESP], Carvalho, Augusto Cesinando de [UNESP], Garner, David Matthew, Marques Vanderlei, Luiz Carlos [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/0004-282X-anp-2020-0088; http://hdl.handle.net/11449/210169
• topic: Parkinson Disease; Autonomic Nervous System; Primary Dysautonomias; Neurodegenerative Diseases

Background: Parkinson's disease (PD) produces autonomic changes, indicating lower parasympathetic modulation and global variability, but these changes need further studying regarding geometric methods. Objective: To investigate the autonomic modulation in individuals with PD using heart rate variability (HRV) indices obtained through geometric methods. Methods: This is a cross-sectional study that assessed 50 individuals, split into two groups: PD group (PDG; n=26; 75.36 +/- 5.21 years) and control group (CG; n=24; 75.36 +/- 5.21 years). We evaluated the autonomic modulation by measuring the heart rate beat-to-beat for 30 min with the individual in supine rest using a heart rate monitor and assessed geometric indices (RRtri, TINN, SD1, SD2, SD1/SD2 ratio, and qualitative analysis of the Poincare plot). Results: Significant reductions were found in RRtri, TINN, SD1, and SD2 indices among PDG compared to CG. Regarding the SD1/SD2 ratio, no significant changes were detected between the groups. The Poincare plot demonstrated that individuals with PD had lower beat-to-beat dispersion in RR intervals, in addition to greater long-term dispersion of RR intervals compared to CG. Conclusions: The results suggest a reduction in the parasympathetic autonomic modulation and global variability in individuals with PD compared to controls, regardless of sex, age, and body mass