Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary function

Detalhes bibliográficos
Autor(a) principal: Lopes, Patrícia Cristina Ferro [UNESP]
Data de Publicação: 2014
Outros Autores: Nunes, Newton [UNESP], Belmonte, Emilio de Almeida [UNESP], Almeida, Ricardo Miyasaka [UNESP], Dias, Luís Gustavo Gosuen Gonçalves [UNESP], Pereira Neto, Glaucia Bueno [UNESP], Souza, Ana Leticia Grosczewics [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-6519
http://hdl.handle.net/11449/114186
Resumo: In the initial stage of traumatic brain injury, the use of 1.0 inspired oxygen fraction (FiO2) is indicated. However, high FiO2 has been correlated with atelectasis. Thus, the effects of FiO2 = 1.0 and FiO2 = 0.6 on the cardiopulmonary function in propofol-anesthetized dogs with high intracranial pressure (ICP) were evaluated. Eight dogs were anesthetized on two occasions, receiving, during controlled ventilation, an FiO2 = 1 (G100) or an FiO2 = 0.6 (G60). Propofol was used for induction (10mg.kg-1) followed by a continuous rate infusion (0.6mg.kg-1.minute-1). An increase in the ICP was induced by temporary obliteration of the right jugular vein (OJv) 50 minutes after induction of anesthesia. The measurement was taken twenty minutes after OJv (T0) and then at 15-minute intervals (T15 to T60). Alveolar oxygen partial pressure in G60 was lower than in G100 during the whole procedure. Alveolar-arterial oxygen gradient in G100 was greater than in G60 at T0 and at T60. No differences were observed for arterial oxygen partial pressure/inspired oxygen fraction ratio, arterial-to-alveolar oxygen pressure ratio, respiratory index, venous admixture, oxygen delivery, oxygen consumption, oxygen extraction, heart rate, mean pulmonary arterial pressure, pulmonary arterial occlusion pressure, cardiac index, stroke index and systemic vascular resistance index. In G100, mean arterial pressure at T0 was higher than at T45. In dogs with high ICP, the cardiopulmonary function was not influenced by the different FiO2 used.
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spelling Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary functionDois níveis de fração inspirada de oxigênio em cães anestesiados com propofol e com pressão intracraniana elevada: função cardiopulmonarcãoanestesia intravenosa totalautorregulação cerebralhemodinâmicamistura arteriovenosadogtotal intravenous anesthesiacerebral autoregulationhemodynamicvenous admixtureIn the initial stage of traumatic brain injury, the use of 1.0 inspired oxygen fraction (FiO2) is indicated. However, high FiO2 has been correlated with atelectasis. Thus, the effects of FiO2 = 1.0 and FiO2 = 0.6 on the cardiopulmonary function in propofol-anesthetized dogs with high intracranial pressure (ICP) were evaluated. Eight dogs were anesthetized on two occasions, receiving, during controlled ventilation, an FiO2 = 1 (G100) or an FiO2 = 0.6 (G60). Propofol was used for induction (10mg.kg-1) followed by a continuous rate infusion (0.6mg.kg-1.minute-1). An increase in the ICP was induced by temporary obliteration of the right jugular vein (OJv) 50 minutes after induction of anesthesia. The measurement was taken twenty minutes after OJv (T0) and then at 15-minute intervals (T15 to T60). Alveolar oxygen partial pressure in G60 was lower than in G100 during the whole procedure. Alveolar-arterial oxygen gradient in G100 was greater than in G60 at T0 and at T60. No differences were observed for arterial oxygen partial pressure/inspired oxygen fraction ratio, arterial-to-alveolar oxygen pressure ratio, respiratory index, venous admixture, oxygen delivery, oxygen consumption, oxygen extraction, heart rate, mean pulmonary arterial pressure, pulmonary arterial occlusion pressure, cardiac index, stroke index and systemic vascular resistance index. In G100, mean arterial pressure at T0 was higher than at T45. In dogs with high ICP, the cardiopulmonary function was not influenced by the different FiO2 used.No estágio inicial do trauma encefálico, o emprego de fração inspirada de oxigênio (FiO2) de 1,0 é indicado. Todavia, altas FiO2 têm sido correlacionadas com atelectasia. Assim, avaliaram-se os efeitos das FiO2 = 1.0 e FiO2 = 0.6 sobre a função cardiopulmonar em cães com pressão intracraniana (PIC) elevada e anestesiados com propofol. Oito animais foram anestesiados em duas ocasiões e receberam, durante a ventilação controlada, FiO2 = 1(G100) ou FiO2 = 0,6 (G60). Propofol foi usado para indução (10mg.kg-1) e seguido por infusão contínua (0,6mg.kg-1minuto-1). O aumento da PIC foi induzido pela obliteração temporária da veia jugular (OJv). As mensurações foram realizadas 20 minutos após OJv (T0) e em intervalos de 15 minutos (de T15 a T60). A pressão parcial de oxigênio alveolar no G60 foi menor do que no G100 durante todo o procedimento. O gradiente alveolar-arterial no G100 foi maior do que no G60, em T0 e T60. Não foram observadas diferenças para: relação pressão parcial de oxigênio/fração inspirada de oxigênio, relação arterioalveolar, índice respiratório, mistura arteriovenosa, oferta de oxigênio, consumo de oxigênio, taxa de extração de oxigênio, frequência cardíaca, pressão da artéria pulmonar média, pressão de oclusão da artéria pulmonar, índice cardíaco, índice sistólico e índice de resistência vascular sistêmica. No G100, a pressão arterial média em T0 foi maior do que em T45. Em cães com alta PIC, a função cardiopulmonar não foi influenciada pelas diferentes FiO2 empregadas.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Unesp Faculdade de Ciências Agrárias e VeterináriasUnesp Faculdade de Ciências Agrárias e VeterináriasUniversidade Federal de Minas Gerais, Escola de VeterináriaUniversidade Estadual Paulista (Unesp)Lopes, Patrícia Cristina Ferro [UNESP]Nunes, Newton [UNESP]Belmonte, Emilio de Almeida [UNESP]Almeida, Ricardo Miyasaka [UNESP]Dias, Luís Gustavo Gosuen Gonçalves [UNESP]Pereira Neto, Glaucia Bueno [UNESP]Souza, Ana Leticia Grosczewics [UNESP]2015-02-02T12:39:19Z2015-02-02T12:39:19Z2014-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1351-1358application/pdfhttp://dx.doi.org/10.1590/1678-6519Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Universidade Federal de Minas Gerais, Escola de Veterinária, v. 66, n. 5, p. 1351-1358, 2014.0102-0935http://hdl.handle.net/11449/11418610.1590/1678-6519S0102-09352014000501351S0102-09352014000501351.pdf0023783814889740SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivo Brasileiro de Medicina Veterinária e Zootecnia0.2860,248info:eu-repo/semantics/openAccess2024-06-06T14:08:49Zoai:repositorio.unesp.br:11449/114186Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:10:03.849895Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary function
Dois níveis de fração inspirada de oxigênio em cães anestesiados com propofol e com pressão intracraniana elevada: função cardiopulmonar
title Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary function
spellingShingle Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary function
Lopes, Patrícia Cristina Ferro [UNESP]
cão
anestesia intravenosa total
autorregulação cerebral
hemodinâmica
mistura arteriovenosa
dog
total intravenous anesthesia
cerebral autoregulation
hemodynamic
venous admixture
title_short Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary function
title_full Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary function
title_fullStr Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary function
title_full_unstemmed Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary function
title_sort Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary function
author Lopes, Patrícia Cristina Ferro [UNESP]
author_facet Lopes, Patrícia Cristina Ferro [UNESP]
Nunes, Newton [UNESP]
Belmonte, Emilio de Almeida [UNESP]
Almeida, Ricardo Miyasaka [UNESP]
Dias, Luís Gustavo Gosuen Gonçalves [UNESP]
Pereira Neto, Glaucia Bueno [UNESP]
Souza, Ana Leticia Grosczewics [UNESP]
author_role author
author2 Nunes, Newton [UNESP]
Belmonte, Emilio de Almeida [UNESP]
Almeida, Ricardo Miyasaka [UNESP]
Dias, Luís Gustavo Gosuen Gonçalves [UNESP]
Pereira Neto, Glaucia Bueno [UNESP]
Souza, Ana Leticia Grosczewics [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Lopes, Patrícia Cristina Ferro [UNESP]
Nunes, Newton [UNESP]
Belmonte, Emilio de Almeida [UNESP]
Almeida, Ricardo Miyasaka [UNESP]
Dias, Luís Gustavo Gosuen Gonçalves [UNESP]
Pereira Neto, Glaucia Bueno [UNESP]
Souza, Ana Leticia Grosczewics [UNESP]
dc.subject.por.fl_str_mv cão
anestesia intravenosa total
autorregulação cerebral
hemodinâmica
mistura arteriovenosa
dog
total intravenous anesthesia
cerebral autoregulation
hemodynamic
venous admixture
topic cão
anestesia intravenosa total
autorregulação cerebral
hemodinâmica
mistura arteriovenosa
dog
total intravenous anesthesia
cerebral autoregulation
hemodynamic
venous admixture
description In the initial stage of traumatic brain injury, the use of 1.0 inspired oxygen fraction (FiO2) is indicated. However, high FiO2 has been correlated with atelectasis. Thus, the effects of FiO2 = 1.0 and FiO2 = 0.6 on the cardiopulmonary function in propofol-anesthetized dogs with high intracranial pressure (ICP) were evaluated. Eight dogs were anesthetized on two occasions, receiving, during controlled ventilation, an FiO2 = 1 (G100) or an FiO2 = 0.6 (G60). Propofol was used for induction (10mg.kg-1) followed by a continuous rate infusion (0.6mg.kg-1.minute-1). An increase in the ICP was induced by temporary obliteration of the right jugular vein (OJv) 50 minutes after induction of anesthesia. The measurement was taken twenty minutes after OJv (T0) and then at 15-minute intervals (T15 to T60). Alveolar oxygen partial pressure in G60 was lower than in G100 during the whole procedure. Alveolar-arterial oxygen gradient in G100 was greater than in G60 at T0 and at T60. No differences were observed for arterial oxygen partial pressure/inspired oxygen fraction ratio, arterial-to-alveolar oxygen pressure ratio, respiratory index, venous admixture, oxygen delivery, oxygen consumption, oxygen extraction, heart rate, mean pulmonary arterial pressure, pulmonary arterial occlusion pressure, cardiac index, stroke index and systemic vascular resistance index. In G100, mean arterial pressure at T0 was higher than at T45. In dogs with high ICP, the cardiopulmonary function was not influenced by the different FiO2 used.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01
2015-02-02T12:39:19Z
2015-02-02T12:39:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-6519
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Universidade Federal de Minas Gerais, Escola de Veterinária, v. 66, n. 5, p. 1351-1358, 2014.
0102-0935
http://hdl.handle.net/11449/114186
10.1590/1678-6519
S0102-09352014000501351
S0102-09352014000501351.pdf
0023783814889740
url http://dx.doi.org/10.1590/1678-6519
http://hdl.handle.net/11449/114186
identifier_str_mv Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Universidade Federal de Minas Gerais, Escola de Veterinária, v. 66, n. 5, p. 1351-1358, 2014.
0102-0935
10.1590/1678-6519
S0102-09352014000501351
S0102-09352014000501351.pdf
0023783814889740
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinária e Zootecnia
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1351-1358
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dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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