Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activity
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.cej.2019.04.185 http://hdl.handle.net/11449/185806 |
Resumo: | The degradation of the beta-lactam antibiotic cephalexin (CEX) was carried out by the following electrochemical advanced oxidation processes (EAOPs): anodic oxidation (AO), Fered-Fenton (EF-Fered), photoassisted anodic oxidation (PAO), and photoassisted Fered-Fenton (PEF-Fered). All experiments were done in a flow reactor incorporating a boron-doped diamond anode, at a low current density; for the PAO and PEF-Fered processes, the solution was irradiated with UVA light. The initial removal of CEX was attained by all EAOPs, but it was much faster by the Fenton-based processes, which thus presented higher initial rates of TOC removal. However, the coupling of the electrolytic and UVA photolytic processes enhanced the mineralization process; as a consequence, significantly greater TOC removals were attained by the PEF-Fered and PAO processes. From the initial oxidation intermediates detected by LC-MS/MS for the PEF-Fered and AO processes, it could be concluded that addition reactions involving the electrophilic HO center dot radicals occurred preferentially in the beta-lactam ring; however, due to the higher availability of HO center dot radicals, the Fenton-based process led to a faster rupture of that ring. Thus, the antibacterial activity of the treated CEX solution against Escherichia coli was completely terminated within less than 1 h of treatment by the PEF-Fered process, compared to 8 h by the AO process. The PEF-Fered and PAO processes yielded enhanced degradation performances despite mere use of UVA light. |
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Repositório Institucional da UNESP |
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Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activityFered-Fenton processesUVA photolysisBDD anodeFlow electrolysisDegradation intermediatesThe degradation of the beta-lactam antibiotic cephalexin (CEX) was carried out by the following electrochemical advanced oxidation processes (EAOPs): anodic oxidation (AO), Fered-Fenton (EF-Fered), photoassisted anodic oxidation (PAO), and photoassisted Fered-Fenton (PEF-Fered). All experiments were done in a flow reactor incorporating a boron-doped diamond anode, at a low current density; for the PAO and PEF-Fered processes, the solution was irradiated with UVA light. The initial removal of CEX was attained by all EAOPs, but it was much faster by the Fenton-based processes, which thus presented higher initial rates of TOC removal. However, the coupling of the electrolytic and UVA photolytic processes enhanced the mineralization process; as a consequence, significantly greater TOC removals were attained by the PEF-Fered and PAO processes. From the initial oxidation intermediates detected by LC-MS/MS for the PEF-Fered and AO processes, it could be concluded that addition reactions involving the electrophilic HO center dot radicals occurred preferentially in the beta-lactam ring; however, due to the higher availability of HO center dot radicals, the Fenton-based process led to a faster rupture of that ring. Thus, the antibacterial activity of the treated CEX solution against Escherichia coli was completely terminated within less than 1 h of treatment by the PEF-Fered process, compared to 8 h by the AO process. The PEF-Fered and PAO processes yielded enhanced degradation performances despite mere use of UVA light.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Sao Carlos, Dept Quim, CP 676, BR-13560970 Sao Carlos, SP, BrazilUniv Estadual Paulista, Dept Quim Analit, Inst Quim Araraquara, BR-14800900 Araraquara, SP, BrazilUniv Fed Sao Carlos, Dept Engn Quim, CP 676, BR-13560970 Sao Carlos, SP, BrazilUniv Estadual Paulista, Dept Quim Analit, Inst Quim Araraquara, BR-14800900 Araraquara, SP, BrazilCNPq: 152361/2016-2CNPq: 311970/2017-6CAPES: AUXPE 499/2013FAPESP: 2004/08572-4FAPESP: 2018/10805-0Elsevier B.V.Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (Unesp)Antonin, Vanessa S.Aquino, Jose M.Silva, Bianca F. [UNESP]Silva, Adilson J.Rocha-Filho, Romeu C.2019-10-04T12:38:44Z2019-10-04T12:38:44Z2019-09-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1104-1112http://dx.doi.org/10.1016/j.cej.2019.04.185Chemical Engineering Journal. Lausanne: Elsevier Science Sa, v. 372, p. 1104-1112, 2019.1385-8947http://hdl.handle.net/11449/18580610.1016/j.cej.2019.04.185WOS:000471670400103Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengChemical Engineering Journalinfo:eu-repo/semantics/openAccess2021-10-22T21:15:47Zoai:repositorio.unesp.br:11449/185806Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:19:48.816247Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activity |
title |
Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activity |
spellingShingle |
Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activity Antonin, Vanessa S. Fered-Fenton processes UVA photolysis BDD anode Flow electrolysis Degradation intermediates |
title_short |
Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activity |
title_full |
Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activity |
title_fullStr |
Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activity |
title_full_unstemmed |
Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activity |
title_sort |
Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activity |
author |
Antonin, Vanessa S. |
author_facet |
Antonin, Vanessa S. Aquino, Jose M. Silva, Bianca F. [UNESP] Silva, Adilson J. Rocha-Filho, Romeu C. |
author_role |
author |
author2 |
Aquino, Jose M. Silva, Bianca F. [UNESP] Silva, Adilson J. Rocha-Filho, Romeu C. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Antonin, Vanessa S. Aquino, Jose M. Silva, Bianca F. [UNESP] Silva, Adilson J. Rocha-Filho, Romeu C. |
dc.subject.por.fl_str_mv |
Fered-Fenton processes UVA photolysis BDD anode Flow electrolysis Degradation intermediates |
topic |
Fered-Fenton processes UVA photolysis BDD anode Flow electrolysis Degradation intermediates |
description |
The degradation of the beta-lactam antibiotic cephalexin (CEX) was carried out by the following electrochemical advanced oxidation processes (EAOPs): anodic oxidation (AO), Fered-Fenton (EF-Fered), photoassisted anodic oxidation (PAO), and photoassisted Fered-Fenton (PEF-Fered). All experiments were done in a flow reactor incorporating a boron-doped diamond anode, at a low current density; for the PAO and PEF-Fered processes, the solution was irradiated with UVA light. The initial removal of CEX was attained by all EAOPs, but it was much faster by the Fenton-based processes, which thus presented higher initial rates of TOC removal. However, the coupling of the electrolytic and UVA photolytic processes enhanced the mineralization process; as a consequence, significantly greater TOC removals were attained by the PEF-Fered and PAO processes. From the initial oxidation intermediates detected by LC-MS/MS for the PEF-Fered and AO processes, it could be concluded that addition reactions involving the electrophilic HO center dot radicals occurred preferentially in the beta-lactam ring; however, due to the higher availability of HO center dot radicals, the Fenton-based process led to a faster rupture of that ring. Thus, the antibacterial activity of the treated CEX solution against Escherichia coli was completely terminated within less than 1 h of treatment by the PEF-Fered process, compared to 8 h by the AO process. The PEF-Fered and PAO processes yielded enhanced degradation performances despite mere use of UVA light. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T12:38:44Z 2019-10-04T12:38:44Z 2019-09-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.cej.2019.04.185 Chemical Engineering Journal. Lausanne: Elsevier Science Sa, v. 372, p. 1104-1112, 2019. 1385-8947 http://hdl.handle.net/11449/185806 10.1016/j.cej.2019.04.185 WOS:000471670400103 |
url |
http://dx.doi.org/10.1016/j.cej.2019.04.185 http://hdl.handle.net/11449/185806 |
identifier_str_mv |
Chemical Engineering Journal. Lausanne: Elsevier Science Sa, v. 372, p. 1104-1112, 2019. 1385-8947 10.1016/j.cej.2019.04.185 WOS:000471670400103 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chemical Engineering Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1104-1112 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129416195211264 |