The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution

Detalhes bibliográficos
Autor(a) principal: Cardozo, Jussara Câmara
Data de Publicação: 2022
Outros Autores: da Silva, Djalma Ribeiro, Martínez-Huitle, Carlos A. [UNESP], Quiroz, Marco Antônio, Vieira dos Santos, Elisama [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.electacta.2022.140063
http://hdl.handle.net/11449/223488
Resumo: The electrochemical degradation of dilute aqueous solutions of olanzapine (OL), using boron-doped diamond (BDD) anodes as electrocatalysts, was investigated. The studies were carried out in a single-compartment electrochemical cell at three different current densities (10, 30, and 50 mA cm−2), 25 °C, and 50 mg L−1 of OL in 0.05 M Na2SO4 pH (2.0, 4.0 and 6.0) as supporting electrolyte. The OL concentration and feasible by-products of the oxidized solution were monitored during the oxidation process using UV spectrophotometry, chemical oxygen demand (COD), total organic carbon (TOC), and high-performance liquid chromatography-mass spectrometry (HPLC-MS) techniques. Through voltametric studies, it was revealed that OL oxidation involved a direct oxidation stage, characterized by a current peak at +0.8 V (vs Ag/AgCl3M) that behaved as a quasi-reversible process, and an irreversible oxidation stage as well as an indirect oxidation step at +1.65 V (vs Ag/AgCl3M) mediated by physiosorbed ●OH radicals on BDD surface, which were formed by the discharge of water. The dependence of the peak current (ip), as well as the peak potential (Ep), with the potential sweep rate ν (mV s−1), showed that the oxidation depended on the diffusion of OL towards the BDD surface. By using a chronoamperometric analysis, a value of 6.6 × 10−4 cm2 s−1 was estimated for the diffusion coefficient of OL in 0.05 M Na2SO4 pH 2.0, confirming the transport effects. The results of UV and HPLC showed that the OL removal rate increased as the applied current density increased, although the COD and TOC data showed that a better oxidation is achieved at 30 mA cm−2. The results of HPLC-MS were consistent with the removal processes, involving both direct and indirect OL oxidation steps with BDD electrode. In any case, the results clearly confirmed the OL removal from the aqueous solution, achieving 80% of mineralization at applied current densities greater than 30 mA cm−2.
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spelling The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solutionAntipsychotic drugsBDD anodesElectrooxidationOlanzapineThe electrochemical degradation of dilute aqueous solutions of olanzapine (OL), using boron-doped diamond (BDD) anodes as electrocatalysts, was investigated. The studies were carried out in a single-compartment electrochemical cell at three different current densities (10, 30, and 50 mA cm−2), 25 °C, and 50 mg L−1 of OL in 0.05 M Na2SO4 pH (2.0, 4.0 and 6.0) as supporting electrolyte. The OL concentration and feasible by-products of the oxidized solution were monitored during the oxidation process using UV spectrophotometry, chemical oxygen demand (COD), total organic carbon (TOC), and high-performance liquid chromatography-mass spectrometry (HPLC-MS) techniques. Through voltametric studies, it was revealed that OL oxidation involved a direct oxidation stage, characterized by a current peak at +0.8 V (vs Ag/AgCl3M) that behaved as a quasi-reversible process, and an irreversible oxidation stage as well as an indirect oxidation step at +1.65 V (vs Ag/AgCl3M) mediated by physiosorbed ●OH radicals on BDD surface, which were formed by the discharge of water. The dependence of the peak current (ip), as well as the peak potential (Ep), with the potential sweep rate ν (mV s−1), showed that the oxidation depended on the diffusion of OL towards the BDD surface. By using a chronoamperometric analysis, a value of 6.6 × 10−4 cm2 s−1 was estimated for the diffusion coefficient of OL in 0.05 M Na2SO4 pH 2.0, confirming the transport effects. The results of UV and HPLC showed that the OL removal rate increased as the applied current density increased, although the COD and TOC data showed that a better oxidation is achieved at 30 mA cm−2. The results of HPLC-MS were consistent with the removal processes, involving both direct and indirect OL oxidation steps with BDD electrode. In any case, the results clearly confirmed the OL removal from the aqueous solution, achieving 80% of mineralization at applied current densities greater than 30 mA cm−2.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto de Química Federal University of Rio Grande do Norte, Rio Grande do NorteSchool of Science and Technology Federal University of Rio Grande do NorteNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry UNESP, P.O. Box 355, SPNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry UNESP, P.O. Box 355, SPCNPq: 306323/2018-4CNPq: 312595/2019-0CNPq: 439344/2018-2Federal University of Rio Grande do NorteUniversidade Estadual Paulista (UNESP)Cardozo, Jussara Câmarada Silva, Djalma RibeiroMartínez-Huitle, Carlos A. [UNESP]Quiroz, Marco AntônioVieira dos Santos, Elisama [UNESP]2022-04-28T19:50:55Z2022-04-28T19:50:55Z2022-04-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.electacta.2022.140063Electrochimica Acta, v. 411.0013-4686http://hdl.handle.net/11449/22348810.1016/j.electacta.2022.1400632-s2.0-85124906363Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengElectrochimica Actainfo:eu-repo/semantics/openAccess2022-04-28T19:50:55Zoai:repositorio.unesp.br:11449/223488Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:45:48.622098Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution
title The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution
spellingShingle The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution
Cardozo, Jussara Câmara
Antipsychotic drugs
BDD anodes
Electrooxidation
Olanzapine
title_short The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution
title_full The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution
title_fullStr The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution
title_full_unstemmed The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution
title_sort The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution
author Cardozo, Jussara Câmara
author_facet Cardozo, Jussara Câmara
da Silva, Djalma Ribeiro
Martínez-Huitle, Carlos A. [UNESP]
Quiroz, Marco Antônio
Vieira dos Santos, Elisama [UNESP]
author_role author
author2 da Silva, Djalma Ribeiro
Martínez-Huitle, Carlos A. [UNESP]
Quiroz, Marco Antônio
Vieira dos Santos, Elisama [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Federal University of Rio Grande do Norte
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Cardozo, Jussara Câmara
da Silva, Djalma Ribeiro
Martínez-Huitle, Carlos A. [UNESP]
Quiroz, Marco Antônio
Vieira dos Santos, Elisama [UNESP]
dc.subject.por.fl_str_mv Antipsychotic drugs
BDD anodes
Electrooxidation
Olanzapine
topic Antipsychotic drugs
BDD anodes
Electrooxidation
Olanzapine
description The electrochemical degradation of dilute aqueous solutions of olanzapine (OL), using boron-doped diamond (BDD) anodes as electrocatalysts, was investigated. The studies were carried out in a single-compartment electrochemical cell at three different current densities (10, 30, and 50 mA cm−2), 25 °C, and 50 mg L−1 of OL in 0.05 M Na2SO4 pH (2.0, 4.0 and 6.0) as supporting electrolyte. The OL concentration and feasible by-products of the oxidized solution were monitored during the oxidation process using UV spectrophotometry, chemical oxygen demand (COD), total organic carbon (TOC), and high-performance liquid chromatography-mass spectrometry (HPLC-MS) techniques. Through voltametric studies, it was revealed that OL oxidation involved a direct oxidation stage, characterized by a current peak at +0.8 V (vs Ag/AgCl3M) that behaved as a quasi-reversible process, and an irreversible oxidation stage as well as an indirect oxidation step at +1.65 V (vs Ag/AgCl3M) mediated by physiosorbed ●OH radicals on BDD surface, which were formed by the discharge of water. The dependence of the peak current (ip), as well as the peak potential (Ep), with the potential sweep rate ν (mV s−1), showed that the oxidation depended on the diffusion of OL towards the BDD surface. By using a chronoamperometric analysis, a value of 6.6 × 10−4 cm2 s−1 was estimated for the diffusion coefficient of OL in 0.05 M Na2SO4 pH 2.0, confirming the transport effects. The results of UV and HPLC showed that the OL removal rate increased as the applied current density increased, although the COD and TOC data showed that a better oxidation is achieved at 30 mA cm−2. The results of HPLC-MS were consistent with the removal processes, involving both direct and indirect OL oxidation steps with BDD electrode. In any case, the results clearly confirmed the OL removal from the aqueous solution, achieving 80% of mineralization at applied current densities greater than 30 mA cm−2.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-28T19:50:55Z
2022-04-28T19:50:55Z
2022-04-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.electacta.2022.140063
Electrochimica Acta, v. 411.
0013-4686
http://hdl.handle.net/11449/223488
10.1016/j.electacta.2022.140063
2-s2.0-85124906363
url http://dx.doi.org/10.1016/j.electacta.2022.140063
http://hdl.handle.net/11449/223488
identifier_str_mv Electrochimica Acta, v. 411.
0013-4686
10.1016/j.electacta.2022.140063
2-s2.0-85124906363
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Electrochimica Acta
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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