The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.electacta.2022.140063 http://hdl.handle.net/11449/223488 |
Resumo: | The electrochemical degradation of dilute aqueous solutions of olanzapine (OL), using boron-doped diamond (BDD) anodes as electrocatalysts, was investigated. The studies were carried out in a single-compartment electrochemical cell at three different current densities (10, 30, and 50 mA cm−2), 25 °C, and 50 mg L−1 of OL in 0.05 M Na2SO4 pH (2.0, 4.0 and 6.0) as supporting electrolyte. The OL concentration and feasible by-products of the oxidized solution were monitored during the oxidation process using UV spectrophotometry, chemical oxygen demand (COD), total organic carbon (TOC), and high-performance liquid chromatography-mass spectrometry (HPLC-MS) techniques. Through voltametric studies, it was revealed that OL oxidation involved a direct oxidation stage, characterized by a current peak at +0.8 V (vs Ag/AgCl3M) that behaved as a quasi-reversible process, and an irreversible oxidation stage as well as an indirect oxidation step at +1.65 V (vs Ag/AgCl3M) mediated by physiosorbed ●OH radicals on BDD surface, which were formed by the discharge of water. The dependence of the peak current (ip), as well as the peak potential (Ep), with the potential sweep rate ν (mV s−1), showed that the oxidation depended on the diffusion of OL towards the BDD surface. By using a chronoamperometric analysis, a value of 6.6 × 10−4 cm2 s−1 was estimated for the diffusion coefficient of OL in 0.05 M Na2SO4 pH 2.0, confirming the transport effects. The results of UV and HPLC showed that the OL removal rate increased as the applied current density increased, although the COD and TOC data showed that a better oxidation is achieved at 30 mA cm−2. The results of HPLC-MS were consistent with the removal processes, involving both direct and indirect OL oxidation steps with BDD electrode. In any case, the results clearly confirmed the OL removal from the aqueous solution, achieving 80% of mineralization at applied current densities greater than 30 mA cm−2. |
id |
UNSP_a1261140b6171ac30b265034baf6b771 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/223488 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solutionAntipsychotic drugsBDD anodesElectrooxidationOlanzapineThe electrochemical degradation of dilute aqueous solutions of olanzapine (OL), using boron-doped diamond (BDD) anodes as electrocatalysts, was investigated. The studies were carried out in a single-compartment electrochemical cell at three different current densities (10, 30, and 50 mA cm−2), 25 °C, and 50 mg L−1 of OL in 0.05 M Na2SO4 pH (2.0, 4.0 and 6.0) as supporting electrolyte. The OL concentration and feasible by-products of the oxidized solution were monitored during the oxidation process using UV spectrophotometry, chemical oxygen demand (COD), total organic carbon (TOC), and high-performance liquid chromatography-mass spectrometry (HPLC-MS) techniques. Through voltametric studies, it was revealed that OL oxidation involved a direct oxidation stage, characterized by a current peak at +0.8 V (vs Ag/AgCl3M) that behaved as a quasi-reversible process, and an irreversible oxidation stage as well as an indirect oxidation step at +1.65 V (vs Ag/AgCl3M) mediated by physiosorbed ●OH radicals on BDD surface, which were formed by the discharge of water. The dependence of the peak current (ip), as well as the peak potential (Ep), with the potential sweep rate ν (mV s−1), showed that the oxidation depended on the diffusion of OL towards the BDD surface. By using a chronoamperometric analysis, a value of 6.6 × 10−4 cm2 s−1 was estimated for the diffusion coefficient of OL in 0.05 M Na2SO4 pH 2.0, confirming the transport effects. The results of UV and HPLC showed that the OL removal rate increased as the applied current density increased, although the COD and TOC data showed that a better oxidation is achieved at 30 mA cm−2. The results of HPLC-MS were consistent with the removal processes, involving both direct and indirect OL oxidation steps with BDD electrode. In any case, the results clearly confirmed the OL removal from the aqueous solution, achieving 80% of mineralization at applied current densities greater than 30 mA cm−2.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto de Química Federal University of Rio Grande do Norte, Rio Grande do NorteSchool of Science and Technology Federal University of Rio Grande do NorteNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry UNESP, P.O. Box 355, SPNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry UNESP, P.O. Box 355, SPCNPq: 306323/2018-4CNPq: 312595/2019-0CNPq: 439344/2018-2Federal University of Rio Grande do NorteUniversidade Estadual Paulista (UNESP)Cardozo, Jussara Câmarada Silva, Djalma RibeiroMartínez-Huitle, Carlos A. [UNESP]Quiroz, Marco AntônioVieira dos Santos, Elisama [UNESP]2022-04-28T19:50:55Z2022-04-28T19:50:55Z2022-04-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.electacta.2022.140063Electrochimica Acta, v. 411.0013-4686http://hdl.handle.net/11449/22348810.1016/j.electacta.2022.1400632-s2.0-85124906363Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengElectrochimica Actainfo:eu-repo/semantics/openAccess2022-04-28T19:50:55Zoai:repositorio.unesp.br:11449/223488Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:45:48.622098Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution |
title |
The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution |
spellingShingle |
The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution Cardozo, Jussara Câmara Antipsychotic drugs BDD anodes Electrooxidation Olanzapine |
title_short |
The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution |
title_full |
The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution |
title_fullStr |
The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution |
title_full_unstemmed |
The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution |
title_sort |
The versatile behavior of diamond electrodes — Electrochemical examination of the anti-psychotic drug olanzapine (OL) oxidation as a model organic aqueous solution |
author |
Cardozo, Jussara Câmara |
author_facet |
Cardozo, Jussara Câmara da Silva, Djalma Ribeiro Martínez-Huitle, Carlos A. [UNESP] Quiroz, Marco Antônio Vieira dos Santos, Elisama [UNESP] |
author_role |
author |
author2 |
da Silva, Djalma Ribeiro Martínez-Huitle, Carlos A. [UNESP] Quiroz, Marco Antônio Vieira dos Santos, Elisama [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Federal University of Rio Grande do Norte Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Cardozo, Jussara Câmara da Silva, Djalma Ribeiro Martínez-Huitle, Carlos A. [UNESP] Quiroz, Marco Antônio Vieira dos Santos, Elisama [UNESP] |
dc.subject.por.fl_str_mv |
Antipsychotic drugs BDD anodes Electrooxidation Olanzapine |
topic |
Antipsychotic drugs BDD anodes Electrooxidation Olanzapine |
description |
The electrochemical degradation of dilute aqueous solutions of olanzapine (OL), using boron-doped diamond (BDD) anodes as electrocatalysts, was investigated. The studies were carried out in a single-compartment electrochemical cell at three different current densities (10, 30, and 50 mA cm−2), 25 °C, and 50 mg L−1 of OL in 0.05 M Na2SO4 pH (2.0, 4.0 and 6.0) as supporting electrolyte. The OL concentration and feasible by-products of the oxidized solution were monitored during the oxidation process using UV spectrophotometry, chemical oxygen demand (COD), total organic carbon (TOC), and high-performance liquid chromatography-mass spectrometry (HPLC-MS) techniques. Through voltametric studies, it was revealed that OL oxidation involved a direct oxidation stage, characterized by a current peak at +0.8 V (vs Ag/AgCl3M) that behaved as a quasi-reversible process, and an irreversible oxidation stage as well as an indirect oxidation step at +1.65 V (vs Ag/AgCl3M) mediated by physiosorbed ●OH radicals on BDD surface, which were formed by the discharge of water. The dependence of the peak current (ip), as well as the peak potential (Ep), with the potential sweep rate ν (mV s−1), showed that the oxidation depended on the diffusion of OL towards the BDD surface. By using a chronoamperometric analysis, a value of 6.6 × 10−4 cm2 s−1 was estimated for the diffusion coefficient of OL in 0.05 M Na2SO4 pH 2.0, confirming the transport effects. The results of UV and HPLC showed that the OL removal rate increased as the applied current density increased, although the COD and TOC data showed that a better oxidation is achieved at 30 mA cm−2. The results of HPLC-MS were consistent with the removal processes, involving both direct and indirect OL oxidation steps with BDD electrode. In any case, the results clearly confirmed the OL removal from the aqueous solution, achieving 80% of mineralization at applied current densities greater than 30 mA cm−2. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-28T19:50:55Z 2022-04-28T19:50:55Z 2022-04-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.electacta.2022.140063 Electrochimica Acta, v. 411. 0013-4686 http://hdl.handle.net/11449/223488 10.1016/j.electacta.2022.140063 2-s2.0-85124906363 |
url |
http://dx.doi.org/10.1016/j.electacta.2022.140063 http://hdl.handle.net/11449/223488 |
identifier_str_mv |
Electrochimica Acta, v. 411. 0013-4686 10.1016/j.electacta.2022.140063 2-s2.0-85124906363 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Electrochimica Acta |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129244223504384 |