Anti-inflammatory drug design by molecular hybridization approach

• Autor(a) principal: Bosquesi, Priscila Longhin [UNESP]
• Data de Publicação: 2011
• Outros Autores: Melo, Tais Regina Ferreira [UNESP], Vizioli, Ednir de Oliveira [UNESP], Santos, Jean Leandro dos [UNESP], Chung, Man Chin [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.3390/ph4111450; http://hdl.handle.net/11449/133761
• topic: Anti-inflammatory; Hybridization; Multiple-ligands; Mutual prodrug

The design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the initial trigger of severaldifferent diseases, such as Alzheimer s disease, asthma, atherosclerosis, colitis, rheumatoidarthritis, depression, cancer; and disorders such as obesity and sexual dysfunction.Although inflammation is not the direct cause of these disorders, inflammatory processesoften increase related pain and suffering. New anti-inflammatory drugs developed usingmolecular hybridization techniques to obtain multiple-ligand drugs can act at one or multipletargets, allowing for synergic action and minimizing toxicity. This work is a review of newanti-inflammatory drugs developed using the molecular modification approach.