Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00784-020-03652-3 http://hdl.handle.net/11449/206763 |
Resumo: | Objective: Assess a single local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing (SRP) in nonsurgical periodontal treatment (NPT). Materials and methods: Twenty healthy subjects with periodontitis received SRP+PLGA/PLA nanoparticles loaded with 50 μg of curcumin (N-Curc) or SRP+empty nanoparticles. Probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were monitored at baseline, 30, 90, and 180 days. IL-1α, IL-6, TNFα, and IL-10 in the gingival crevicular fluid (GCF) were assessed by ELISA, and counts of 40 bacterial species were determined by DNA hybridization at baseline, 3, 7, and 15 days post-therapy. Results: PPD, CAL, and BOP were similarly and significantly improved in both experimental groups. There was no difference in GCF cytokine levels between experimental groups, although IL-6 was decreased at 3 days only in the N-Curc group. NPT reduced counts of red complex bacterial species in both groups. Veillonella Parvula counts increased significantly only in N-Curc group at 7 days, whereas Aggregatibacter actinomycetemcomitans counts increased significantly only in the control group from day 3 to day 15. Conclusion: We conclude that a single local administration of nanoencapsulated curcumin in periodontally diseased sites had no additive benefits to NPT. Clinical relevance: Our results showed that a single local application of curcumin-loaded nanoparticles associated with nonsurgical periodontal therapy did not improve clinical outcomes. Hence, our findings do not support the use of curcumin as an adjunct to nonsurgical periodontal therapy. |
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Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trialCurcuminDental ScalingNanoparticlesPeriodontitisObjective: Assess a single local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing (SRP) in nonsurgical periodontal treatment (NPT). Materials and methods: Twenty healthy subjects with periodontitis received SRP+PLGA/PLA nanoparticles loaded with 50 μg of curcumin (N-Curc) or SRP+empty nanoparticles. Probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were monitored at baseline, 30, 90, and 180 days. IL-1α, IL-6, TNFα, and IL-10 in the gingival crevicular fluid (GCF) were assessed by ELISA, and counts of 40 bacterial species were determined by DNA hybridization at baseline, 3, 7, and 15 days post-therapy. Results: PPD, CAL, and BOP were similarly and significantly improved in both experimental groups. There was no difference in GCF cytokine levels between experimental groups, although IL-6 was decreased at 3 days only in the N-Curc group. NPT reduced counts of red complex bacterial species in both groups. Veillonella Parvula counts increased significantly only in N-Curc group at 7 days, whereas Aggregatibacter actinomycetemcomitans counts increased significantly only in the control group from day 3 to day 15. Conclusion: We conclude that a single local administration of nanoencapsulated curcumin in periodontally diseased sites had no additive benefits to NPT. Clinical relevance: Our results showed that a single local application of curcumin-loaded nanoparticles associated with nonsurgical periodontal therapy did not improve clinical outcomes. Hence, our findings do not support the use of curcumin as an adjunct to nonsurgical periodontal therapy.Department of Diagnosis and Surgery School of Dentistry at Araraquara Sao Paulo State University (UNESP)Department of Bioprocess and Biotechnology Faculty of Pharmaceutical Sciences of Araraquara Sao Paulo State University (UNESP)Department of Chemistry Center of Nanotechnology and Tissue Engineering- Photobiology and Photomedicine Research Group Faculty of Philosophy Sciences and Letters of Ribeirao Preto University of Sao PauloBiostatistics University of Michigan School of Public HealthDepartment of Periodontology and Oral Implantology Dental Research Division Universidade de Guarulhos - UNGDepartment of Diagnosis and Surgery School of Dentistry at Araraquara Sao Paulo State University (UNESP)Department of Bioprocess and Biotechnology Faculty of Pharmaceutical Sciences of Araraquara Sao Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)University of Michigan School of Public HealthUniversidade de Guarulhos - UNGPérez-Pacheco, Cindy Grace [UNESP]Fernandes, Natalie Ap. Rodrigues [UNESP]Primo, Fernando Lucas [UNESP]Tedesco, Antonio ClaudioBellile, EmilyRetamal-Valdes, BelenFeres, MagdaGuimarães-Stabili, Morgana Rodrigues [UNESP]Rossa, Carlos [UNESP]2021-06-25T10:37:43Z2021-06-25T10:37:43Z2021-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article3217-3227http://dx.doi.org/10.1007/s00784-020-03652-3Clinical Oral Investigations, v. 25, n. 5, p. 3217-3227, 2021.1436-37711432-6981http://hdl.handle.net/11449/20676310.1007/s00784-020-03652-32-s2.0-85094683853Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Oral Investigationsinfo:eu-repo/semantics/openAccess2021-10-23T14:48:25Zoai:repositorio.unesp.br:11449/206763Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:39:33.228958Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial |
title |
Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial |
spellingShingle |
Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial Pérez-Pacheco, Cindy Grace [UNESP] Curcumin Dental Scaling Nanoparticles Periodontitis |
title_short |
Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial |
title_full |
Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial |
title_fullStr |
Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial |
title_full_unstemmed |
Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial |
title_sort |
Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial |
author |
Pérez-Pacheco, Cindy Grace [UNESP] |
author_facet |
Pérez-Pacheco, Cindy Grace [UNESP] Fernandes, Natalie Ap. Rodrigues [UNESP] Primo, Fernando Lucas [UNESP] Tedesco, Antonio Claudio Bellile, Emily Retamal-Valdes, Belen Feres, Magda Guimarães-Stabili, Morgana Rodrigues [UNESP] Rossa, Carlos [UNESP] |
author_role |
author |
author2 |
Fernandes, Natalie Ap. Rodrigues [UNESP] Primo, Fernando Lucas [UNESP] Tedesco, Antonio Claudio Bellile, Emily Retamal-Valdes, Belen Feres, Magda Guimarães-Stabili, Morgana Rodrigues [UNESP] Rossa, Carlos [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) University of Michigan School of Public Health Universidade de Guarulhos - UNG |
dc.contributor.author.fl_str_mv |
Pérez-Pacheco, Cindy Grace [UNESP] Fernandes, Natalie Ap. Rodrigues [UNESP] Primo, Fernando Lucas [UNESP] Tedesco, Antonio Claudio Bellile, Emily Retamal-Valdes, Belen Feres, Magda Guimarães-Stabili, Morgana Rodrigues [UNESP] Rossa, Carlos [UNESP] |
dc.subject.por.fl_str_mv |
Curcumin Dental Scaling Nanoparticles Periodontitis |
topic |
Curcumin Dental Scaling Nanoparticles Periodontitis |
description |
Objective: Assess a single local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing (SRP) in nonsurgical periodontal treatment (NPT). Materials and methods: Twenty healthy subjects with periodontitis received SRP+PLGA/PLA nanoparticles loaded with 50 μg of curcumin (N-Curc) or SRP+empty nanoparticles. Probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were monitored at baseline, 30, 90, and 180 days. IL-1α, IL-6, TNFα, and IL-10 in the gingival crevicular fluid (GCF) were assessed by ELISA, and counts of 40 bacterial species were determined by DNA hybridization at baseline, 3, 7, and 15 days post-therapy. Results: PPD, CAL, and BOP were similarly and significantly improved in both experimental groups. There was no difference in GCF cytokine levels between experimental groups, although IL-6 was decreased at 3 days only in the N-Curc group. NPT reduced counts of red complex bacterial species in both groups. Veillonella Parvula counts increased significantly only in N-Curc group at 7 days, whereas Aggregatibacter actinomycetemcomitans counts increased significantly only in the control group from day 3 to day 15. Conclusion: We conclude that a single local administration of nanoencapsulated curcumin in periodontally diseased sites had no additive benefits to NPT. Clinical relevance: Our results showed that a single local application of curcumin-loaded nanoparticles associated with nonsurgical periodontal therapy did not improve clinical outcomes. Hence, our findings do not support the use of curcumin as an adjunct to nonsurgical periodontal therapy. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:37:43Z 2021-06-25T10:37:43Z 2021-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00784-020-03652-3 Clinical Oral Investigations, v. 25, n. 5, p. 3217-3227, 2021. 1436-3771 1432-6981 http://hdl.handle.net/11449/206763 10.1007/s00784-020-03652-3 2-s2.0-85094683853 |
url |
http://dx.doi.org/10.1007/s00784-020-03652-3 http://hdl.handle.net/11449/206763 |
identifier_str_mv |
Clinical Oral Investigations, v. 25, n. 5, p. 3217-3227, 2021. 1436-3771 1432-6981 10.1007/s00784-020-03652-3 2-s2.0-85094683853 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Oral Investigations |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3217-3227 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128546579677184 |