A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubes

Detalhes bibliográficos
Autor(a) principal: Recco, Lucas C. [UNESP]
Data de Publicação: 2016
Outros Autores: Crulhas, Bruno P. [UNESP], Parra, João P. R. L. L. [UNESP], Pedrosa, Valber A. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1039/c6ra05151k
http://hdl.handle.net/11449/173012
Resumo: Direct detection of dopamine (DA) in serum samples without any type of extraction or pre-treatment has been a great challenge for biomedical analysis. This paper reports the development of a sensor consisting of polymer brushes reinforced with multi-walled carbon nanotubes, that was used to determine levels of dopamine in human blood serum. The structure and morphology of the as-prepared hybrid nanomaterials were characterized and confirmed by scanning electron microscopy and electrochemistry techniques. This methodology employs differential pulse voltammetry to detect dopamine in human serum samples at concentrations ranging from 0.1 μM to 10 μM with an obtained detection limit of 40.5 nmol L-1 (R = 0.996). This sensor provides an inexpensive and easy-to-use device with high degrees of sensitivity and selectivity for monitoring DA in human blood serum samples.
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spelling A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubesDirect detection of dopamine (DA) in serum samples without any type of extraction or pre-treatment has been a great challenge for biomedical analysis. This paper reports the development of a sensor consisting of polymer brushes reinforced with multi-walled carbon nanotubes, that was used to determine levels of dopamine in human blood serum. The structure and morphology of the as-prepared hybrid nanomaterials were characterized and confirmed by scanning electron microscopy and electrochemistry techniques. This methodology employs differential pulse voltammetry to detect dopamine in human serum samples at concentrations ranging from 0.1 μM to 10 μM with an obtained detection limit of 40.5 nmol L-1 (R = 0.996). This sensor provides an inexpensive and easy-to-use device with high degrees of sensitivity and selectivity for monitoring DA in human blood serum samples.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Chemistry and Biochemistry Institute of Bioscience UNESPDepartment of Chemistry and Biochemistry Institute of Bioscience UNESPUniversidade Estadual Paulista (Unesp)Recco, Lucas C. [UNESP]Crulhas, Bruno P. [UNESP]Parra, João P. R. L. L. [UNESP]Pedrosa, Valber A. [UNESP]2018-12-11T17:03:06Z2018-12-11T17:03:06Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article47134-47137http://dx.doi.org/10.1039/c6ra05151kRSC Advances, v. 6, n. 52, p. 47134-47137, 2016.2046-2069http://hdl.handle.net/11449/17301210.1039/c6ra05151k2-s2.0-84971290760Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRSC Advances0,863info:eu-repo/semantics/openAccess2021-10-23T17:37:00Zoai:repositorio.unesp.br:11449/173012Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:19:05.293983Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubes
title A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubes
spellingShingle A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubes
Recco, Lucas C. [UNESP]
title_short A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubes
title_full A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubes
title_fullStr A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubes
title_full_unstemmed A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubes
title_sort A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubes
author Recco, Lucas C. [UNESP]
author_facet Recco, Lucas C. [UNESP]
Crulhas, Bruno P. [UNESP]
Parra, João P. R. L. L. [UNESP]
Pedrosa, Valber A. [UNESP]
author_role author
author2 Crulhas, Bruno P. [UNESP]
Parra, João P. R. L. L. [UNESP]
Pedrosa, Valber A. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Recco, Lucas C. [UNESP]
Crulhas, Bruno P. [UNESP]
Parra, João P. R. L. L. [UNESP]
Pedrosa, Valber A. [UNESP]
description Direct detection of dopamine (DA) in serum samples without any type of extraction or pre-treatment has been a great challenge for biomedical analysis. This paper reports the development of a sensor consisting of polymer brushes reinforced with multi-walled carbon nanotubes, that was used to determine levels of dopamine in human blood serum. The structure and morphology of the as-prepared hybrid nanomaterials were characterized and confirmed by scanning electron microscopy and electrochemistry techniques. This methodology employs differential pulse voltammetry to detect dopamine in human serum samples at concentrations ranging from 0.1 μM to 10 μM with an obtained detection limit of 40.5 nmol L-1 (R = 0.996). This sensor provides an inexpensive and easy-to-use device with high degrees of sensitivity and selectivity for monitoring DA in human blood serum samples.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
2018-12-11T17:03:06Z
2018-12-11T17:03:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1039/c6ra05151k
RSC Advances, v. 6, n. 52, p. 47134-47137, 2016.
2046-2069
http://hdl.handle.net/11449/173012
10.1039/c6ra05151k
2-s2.0-84971290760
url http://dx.doi.org/10.1039/c6ra05151k
http://hdl.handle.net/11449/173012
identifier_str_mv RSC Advances, v. 6, n. 52, p. 47134-47137, 2016.
2046-2069
10.1039/c6ra05151k
2-s2.0-84971290760
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv RSC Advances
0,863
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 47134-47137
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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