Direct electrochemical detection of Estriol in serum by polymer brushes reinforced with carbon nanotubes
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1149/2.0081608jss http://hdl.handle.net/11449/173205 |
Resumo: | The aim of this study was the development a simple and sensitive sensor for estriol detection in serum based on the combination of multiwalled carbon nanotubes with polymer brushes that provides a nanocomposite with high electrochemical response. Scanning electron microscopy was applied for characterization of the surface morphology of the modified electrodes and cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy were used to investigate the electrochemical properties of the proposed electrode. Linearity between oxidation peak current and estriol concentration was obtained ranging from 2.0 × 10-6 M to 15 × 10-6 M with a detection limit of 90 nM and sensitivity was calculated to be 0.15 μA/μM. The polymer reinforced carbon nanotube displayed high selectivity, good stability and reproducibility, making it suitable for the routine analysis of estriol in clinical use. |
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Repositório Institucional da UNESP |
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2946 |
spelling |
Direct electrochemical detection of Estriol in serum by polymer brushes reinforced with carbon nanotubesThe aim of this study was the development a simple and sensitive sensor for estriol detection in serum based on the combination of multiwalled carbon nanotubes with polymer brushes that provides a nanocomposite with high electrochemical response. Scanning electron microscopy was applied for characterization of the surface morphology of the modified electrodes and cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy were used to investigate the electrochemical properties of the proposed electrode. Linearity between oxidation peak current and estriol concentration was obtained ranging from 2.0 × 10-6 M to 15 × 10-6 M with a detection limit of 90 nM and sensitivity was calculated to be 0.15 μA/μM. The polymer reinforced carbon nanotube displayed high selectivity, good stability and reproducibility, making it suitable for the routine analysis of estriol in clinical use.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Institute of Bioscience Department of Chemistry and Biochemistry UNESP-BotucatuInstitute of Bioscience Department of Chemistry and Biochemistry UNESP-BotucatuFAPESP: 2014/05653-5Universidade Estadual Paulista (Unesp)Recco, Lucas [UNESP]Crulhas, Bruno P. [UNESP]Basso, Caroline R. [UNESP]Castro, Gustavo R. [UNESP]Pedrosa, Valber A. [UNESP]2018-12-11T17:04:08Z2018-12-11T17:04:08Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleM3041-M3044application/pdfhttp://dx.doi.org/10.1149/2.0081608jssECS Journal of Solid State Science and Technology, v. 5, n. 8, p. M3041-M3044, 2016.2162-87772162-8769http://hdl.handle.net/11449/17320510.1149/2.0081608jss2-s2.0-849780449832-s2.0-84978044983.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengECS Journal of Solid State Science and Technology0,5930,593info:eu-repo/semantics/openAccess2023-12-10T06:22:50Zoai:repositorio.unesp.br:11449/173205Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:59:09.102574Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Direct electrochemical detection of Estriol in serum by polymer brushes reinforced with carbon nanotubes |
title |
Direct electrochemical detection of Estriol in serum by polymer brushes reinforced with carbon nanotubes |
spellingShingle |
Direct electrochemical detection of Estriol in serum by polymer brushes reinforced with carbon nanotubes Recco, Lucas [UNESP] |
title_short |
Direct electrochemical detection of Estriol in serum by polymer brushes reinforced with carbon nanotubes |
title_full |
Direct electrochemical detection of Estriol in serum by polymer brushes reinforced with carbon nanotubes |
title_fullStr |
Direct electrochemical detection of Estriol in serum by polymer brushes reinforced with carbon nanotubes |
title_full_unstemmed |
Direct electrochemical detection of Estriol in serum by polymer brushes reinforced with carbon nanotubes |
title_sort |
Direct electrochemical detection of Estriol in serum by polymer brushes reinforced with carbon nanotubes |
author |
Recco, Lucas [UNESP] |
author_facet |
Recco, Lucas [UNESP] Crulhas, Bruno P. [UNESP] Basso, Caroline R. [UNESP] Castro, Gustavo R. [UNESP] Pedrosa, Valber A. [UNESP] |
author_role |
author |
author2 |
Crulhas, Bruno P. [UNESP] Basso, Caroline R. [UNESP] Castro, Gustavo R. [UNESP] Pedrosa, Valber A. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Recco, Lucas [UNESP] Crulhas, Bruno P. [UNESP] Basso, Caroline R. [UNESP] Castro, Gustavo R. [UNESP] Pedrosa, Valber A. [UNESP] |
description |
The aim of this study was the development a simple and sensitive sensor for estriol detection in serum based on the combination of multiwalled carbon nanotubes with polymer brushes that provides a nanocomposite with high electrochemical response. Scanning electron microscopy was applied for characterization of the surface morphology of the modified electrodes and cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy were used to investigate the electrochemical properties of the proposed electrode. Linearity between oxidation peak current and estriol concentration was obtained ranging from 2.0 × 10-6 M to 15 × 10-6 M with a detection limit of 90 nM and sensitivity was calculated to be 0.15 μA/μM. The polymer reinforced carbon nanotube displayed high selectivity, good stability and reproducibility, making it suitable for the routine analysis of estriol in clinical use. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2018-12-11T17:04:08Z 2018-12-11T17:04:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1149/2.0081608jss ECS Journal of Solid State Science and Technology, v. 5, n. 8, p. M3041-M3044, 2016. 2162-8777 2162-8769 http://hdl.handle.net/11449/173205 10.1149/2.0081608jss 2-s2.0-84978044983 2-s2.0-84978044983.pdf |
url |
http://dx.doi.org/10.1149/2.0081608jss http://hdl.handle.net/11449/173205 |
identifier_str_mv |
ECS Journal of Solid State Science and Technology, v. 5, n. 8, p. M3041-M3044, 2016. 2162-8777 2162-8769 10.1149/2.0081608jss 2-s2.0-84978044983 2-s2.0-84978044983.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
ECS Journal of Solid State Science and Technology 0,593 0,593 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
M3041-M3044 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129145767460864 |