Cardioprotection Generated by Aerobic Exercise Training is Not Related to the Proliferation of Cardiomyocytes and Angiotensin-(1-7) Levels in the Hearts of Rats with Supravalvar Aortic Stenosis

• Autor(a) principal: Augusto Ferreira Mota, Gustavo [UNESP]
• Data de Publicação: 2020
• Outros Autores: Luiz Borges de Souza, Sérgio [UNESP], Loureiro da Silva, Vitor [UNESP], Gatto, Mariana [UNESP], Henrique Salomé de Campos, Dijon [UNESP], Grippa Sant’Ana, Paula [UNESP], Vileigas, Danielle Fernandes [UNESP], Padovani, Carlos Roberto [UNESP], Casarini, Dulce Elena, Menezes de Oliveira, Edilamar, Garcia Zanati Bazan, Silméia [UNESP], Fernandes, Tiago, Sugizaki, Mario Mateus [UNESP], Ricardo de Morais Gomes, Enéas [UNESP], Cicogna, Antonio Carlos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.33594/000000251; http://hdl.handle.net/11449/206496
• topic: Cardiac dysfunction; Cardiac remodeling; Cell cycle; Physical training; Renin-angiotensin system

Background/Aims: The beneficial effect of aerobic exercise training (ET) on cardiac remodeling caused by supravalvar aortic stenosis (AS) has been demonstrated in experimental studies; however, the mechanisms responsible for improving cardiac function are not entirely understood. We evaluated whether ET-generated cardioprotection in pressure-overloaded rats is dependent on cardiomyocyte proliferation, increased angiotensin-(1-7) (Ang-1-7) levels, and its receptor in the myocardium. Methods: Eighteen weeks after ascending AS surgery, Wistar rats were randomly assigned to four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary aortic stenosis (AS-Sed) and exercised aortic stenosis (AS-Ex) groups. The moderate treadmill exercise protocol was performed for ten weeks. The functional capacity was assessed by treadmill exercise testing. Cardiac structure and function were evaluated by echo.