Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats?
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/S1734-1140(11)70614-4 http://hdl.handle.net/11449/226539 |
Resumo: | Diabetic neuropathy can affect the male reproductive system. The aim of this study was therefore to evaluate whether antioxidant (vitamins C and/or E) treatment could attenuate reproductive dysfunctions in hyperglycemic adult male rats. The animals were randomly assigned to one of four experimental groups: hyperglycemic control (Hy), hyperglycemic + 150 mg/day vitamin C (HyC), hyperglycemic + 100 mg/day vitamin E (HyE) or hyperglycemic + vitamins C and E (HyCE). The normoglycemic group (n = 10) received only the vehicles. The testosterone level and noradrenergic response of the vas deferens were analyzed. Both vitamins significantly decreased the TBARS (thiobarbituric acid reactive species) level in the hyperglycemic groups. There was a significant reduction in the testosterone level in the Hy and HyE groups when compared to the normoglycemic group. However, the testosterone levels were partially recovered in the HyC and HyCE groups. In addition, an increased sensitivity of the α-1 adrenoceptor in the vas deferens of the hyperglycemic control group was observed. Treatment with vitamins partially restored (vitamin E or in combination with vitamin C) or totally (vitamin C alone) this dysfunction. Moreover, the maximum response values to norepinephrine were similar among all groups. Thus, we concluded that vitamin C is more efficient than vitamin E in attenuating the effects of hyperglycemia on the male reproductive system of adult rats. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences. |
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Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats?HyperglycemiaMale ratMale reproductive systemNorepinephrineTestosteroneVas deferensVitamin CVitamin EDiabetic neuropathy can affect the male reproductive system. The aim of this study was therefore to evaluate whether antioxidant (vitamins C and/or E) treatment could attenuate reproductive dysfunctions in hyperglycemic adult male rats. The animals were randomly assigned to one of four experimental groups: hyperglycemic control (Hy), hyperglycemic + 150 mg/day vitamin C (HyC), hyperglycemic + 100 mg/day vitamin E (HyE) or hyperglycemic + vitamins C and E (HyCE). The normoglycemic group (n = 10) received only the vehicles. The testosterone level and noradrenergic response of the vas deferens were analyzed. Both vitamins significantly decreased the TBARS (thiobarbituric acid reactive species) level in the hyperglycemic groups. There was a significant reduction in the testosterone level in the Hy and HyE groups when compared to the normoglycemic group. However, the testosterone levels were partially recovered in the HyC and HyCE groups. In addition, an increased sensitivity of the α-1 adrenoceptor in the vas deferens of the hyperglycemic control group was observed. Treatment with vitamins partially restored (vitamin E or in combination with vitamin C) or totally (vitamin C alone) this dysfunction. Moreover, the maximum response values to norepinephrine were similar among all groups. Thus, we concluded that vitamin C is more efficient than vitamin E in attenuating the effects of hyperglycemia on the male reproductive system of adult rats. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences.Institute of Biology State University of Campinas -UNICAMP Cidade Universitária Zeferino Vaz, 13083-862, Campinas, SPDepartment of Physiological Sciences State University of Londrina Londrina - UEL, Celso Garcia Cid, 86051-980, Londrina, PRDepartment of Morphology Institute of Biosciences UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SPDepartment of Gynecology and Obstetrics Botucatu Medical School UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SPDepartment of Pharmacology Institute of Biosciences UNESP - Univ. Estadual Paulista, Distrito de Rubião Jr. s/n, 18618-000, Botucatu, SPDepartment of Morphology Institute of Biosciences UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SPDepartment of Gynecology and Obstetrics Botucatu Medical School UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SPDepartment of Pharmacology Institute of Biosciences UNESP - Univ. Estadual Paulista, Distrito de Rubião Jr. s/n, 18618-000, Botucatu, SPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual de Londrina (UEL)Universidade Estadual Paulista (UNESP)Fernandes, Glaura S. A.Gerardin, Daniela C. C.Assumpção, Thaiane A. [UNESP]Campos, Kleber E. [UNESP]Damasceno, Débora C. [UNESP]Pereira, Oduvaldo C. M. [UNESP]Kempinas, Wilma D. G. [UNESP]2022-04-29T01:01:42Z2022-04-29T01:01:42Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article983-991http://dx.doi.org/10.1016/S1734-1140(11)70614-4Pharmacological Reports, v. 63, n. 4, p. 983-991, 2011.1734-1140http://hdl.handle.net/11449/22653910.1016/S1734-1140(11)70614-42-s2.0-80053357348Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmacological Reportsinfo:eu-repo/semantics/openAccess2022-04-29T01:01:42Zoai:repositorio.unesp.br:11449/226539Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T01:01:42Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats? |
title |
Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats? |
spellingShingle |
Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats? Fernandes, Glaura S. A. Hyperglycemia Male rat Male reproductive system Norepinephrine Testosterone Vas deferens Vitamin C Vitamin E |
title_short |
Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats? |
title_full |
Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats? |
title_fullStr |
Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats? |
title_full_unstemmed |
Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats? |
title_sort |
Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats? |
author |
Fernandes, Glaura S. A. |
author_facet |
Fernandes, Glaura S. A. Gerardin, Daniela C. C. Assumpção, Thaiane A. [UNESP] Campos, Kleber E. [UNESP] Damasceno, Débora C. [UNESP] Pereira, Oduvaldo C. M. [UNESP] Kempinas, Wilma D. G. [UNESP] |
author_role |
author |
author2 |
Gerardin, Daniela C. C. Assumpção, Thaiane A. [UNESP] Campos, Kleber E. [UNESP] Damasceno, Débora C. [UNESP] Pereira, Oduvaldo C. M. [UNESP] Kempinas, Wilma D. G. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual de Londrina (UEL) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Fernandes, Glaura S. A. Gerardin, Daniela C. C. Assumpção, Thaiane A. [UNESP] Campos, Kleber E. [UNESP] Damasceno, Débora C. [UNESP] Pereira, Oduvaldo C. M. [UNESP] Kempinas, Wilma D. G. [UNESP] |
dc.subject.por.fl_str_mv |
Hyperglycemia Male rat Male reproductive system Norepinephrine Testosterone Vas deferens Vitamin C Vitamin E |
topic |
Hyperglycemia Male rat Male reproductive system Norepinephrine Testosterone Vas deferens Vitamin C Vitamin E |
description |
Diabetic neuropathy can affect the male reproductive system. The aim of this study was therefore to evaluate whether antioxidant (vitamins C and/or E) treatment could attenuate reproductive dysfunctions in hyperglycemic adult male rats. The animals were randomly assigned to one of four experimental groups: hyperglycemic control (Hy), hyperglycemic + 150 mg/day vitamin C (HyC), hyperglycemic + 100 mg/day vitamin E (HyE) or hyperglycemic + vitamins C and E (HyCE). The normoglycemic group (n = 10) received only the vehicles. The testosterone level and noradrenergic response of the vas deferens were analyzed. Both vitamins significantly decreased the TBARS (thiobarbituric acid reactive species) level in the hyperglycemic groups. There was a significant reduction in the testosterone level in the Hy and HyE groups when compared to the normoglycemic group. However, the testosterone levels were partially recovered in the HyC and HyCE groups. In addition, an increased sensitivity of the α-1 adrenoceptor in the vas deferens of the hyperglycemic control group was observed. Treatment with vitamins partially restored (vitamin E or in combination with vitamin C) or totally (vitamin C alone) this dysfunction. Moreover, the maximum response values to norepinephrine were similar among all groups. Thus, we concluded that vitamin C is more efficient than vitamin E in attenuating the effects of hyperglycemia on the male reproductive system of adult rats. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 2022-04-29T01:01:42Z 2022-04-29T01:01:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/S1734-1140(11)70614-4 Pharmacological Reports, v. 63, n. 4, p. 983-991, 2011. 1734-1140 http://hdl.handle.net/11449/226539 10.1016/S1734-1140(11)70614-4 2-s2.0-80053357348 |
url |
http://dx.doi.org/10.1016/S1734-1140(11)70614-4 http://hdl.handle.net/11449/226539 |
identifier_str_mv |
Pharmacological Reports, v. 63, n. 4, p. 983-991, 2011. 1734-1140 10.1016/S1734-1140(11)70614-4 2-s2.0-80053357348 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmacological Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
983-991 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803046274420703232 |