Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1677-5449.190025 http://hdl.handle.net/11449/201762 |
Resumo: | Background: Aortic cross-clamping and balloon occlusion of the aorta could lead to damage to the aorta wall. Objective: The aim of this study was to investigate changes to the aorta wall related to the method used to interrupt flow (clamping or balloon) in the different techniques available for aortic surgery. Methods: Experiments were performed on 40 female pigs, weighing 25-30kg, which were randomly allocated to 4 study groups: S (n=10), no intervention (sham group); C (n=10), midline transperitoneal laparotomy for infrarenal abdominal aortic access with 60 min of cross-clamping; L (n=10), laparoscopic infrarenal abdominal aortic surgery with 60 min of cross-clamping; EV (n=10), remote proximal aortic control with transfemoral arterial insertion of aortic occlusion balloon catheter, inflated to provide continued aortic occlusion for 60min. After euthanasia, the aortas were removed and cross-sectioned to obtain histological specimens for light microscopic and morphometric analyses. The remaining longitudinal segments were stretched to rupture and mechanical parameters were determined. Results: We observed a reduction in the yield point of the abdominal aorta, decrease in stiffness and in failure load in the aortic cross-clamping groups (C and L) compared with the EV group. Conclusions: Aortic cross-clamping during open or laparoscopic surgery can affect the mechanical properties of the aorta leading to decrease in resistance of the aorta wall, without structural changes in aorta wall histology. |
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Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approachesLesão aguda da parede arterial provocada pelo método de interrupção temporária de fluxo em diferentes vias de cirurgia aórtica: Estudo morfológico e biomecânico da aorta de porcosAbdominal aortaMechanical stressTensile strengthVascular closure devicesBackground: Aortic cross-clamping and balloon occlusion of the aorta could lead to damage to the aorta wall. Objective: The aim of this study was to investigate changes to the aorta wall related to the method used to interrupt flow (clamping or balloon) in the different techniques available for aortic surgery. Methods: Experiments were performed on 40 female pigs, weighing 25-30kg, which were randomly allocated to 4 study groups: S (n=10), no intervention (sham group); C (n=10), midline transperitoneal laparotomy for infrarenal abdominal aortic access with 60 min of cross-clamping; L (n=10), laparoscopic infrarenal abdominal aortic surgery with 60 min of cross-clamping; EV (n=10), remote proximal aortic control with transfemoral arterial insertion of aortic occlusion balloon catheter, inflated to provide continued aortic occlusion for 60min. After euthanasia, the aortas were removed and cross-sectioned to obtain histological specimens for light microscopic and morphometric analyses. The remaining longitudinal segments were stretched to rupture and mechanical parameters were determined. Results: We observed a reduction in the yield point of the abdominal aorta, decrease in stiffness and in failure load in the aortic cross-clamping groups (C and L) compared with the EV group. Conclusions: Aortic cross-clamping during open or laparoscopic surgery can affect the mechanical properties of the aorta leading to decrease in resistance of the aorta wall, without structural changes in aorta wall histology.Universidade Estadual Paulista – UNESP Faculdade de Medicina de BotucatuUniversidade Estadual Paulista – UNESP Faculdade de Medicina de BotucatuUniversidade Estadual Paulista (Unesp)Prata, Marcela Polachini [UNESP]Jaldin, Rodrigo Gibin [UNESP]Lourenção, Pedro Luiz Toledo de Arruda [UNESP]Sobreira, Marcone Lima [UNESP]Yoshida, Ricardo de Alvarenga [UNESP]Terra, Simone Antunes [UNESP]Viero, Rosa Marlene [UNESP]Yoshida, Winston Bonetti [UNESP]2020-12-12T02:41:08Z2020-12-12T02:41:08Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1590/1677-5449.190025Jornal Vascular Brasileiro, v. 19.1677-73011677-5449http://hdl.handle.net/11449/20176210.1590/1677-5449.190025S1677-544920200001003062-s2.0-85084843438S1677-54492020000100306.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJornal Vascular Brasileiroinfo:eu-repo/semantics/openAccess2024-09-03T13:14:52Zoai:repositorio.unesp.br:11449/201762Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches Lesão aguda da parede arterial provocada pelo método de interrupção temporária de fluxo em diferentes vias de cirurgia aórtica: Estudo morfológico e biomecânico da aorta de porcos |
title |
Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches |
spellingShingle |
Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches Prata, Marcela Polachini [UNESP] Abdominal aorta Mechanical stress Tensile strength Vascular closure devices |
title_short |
Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches |
title_full |
Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches |
title_fullStr |
Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches |
title_full_unstemmed |
Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches |
title_sort |
Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches |
author |
Prata, Marcela Polachini [UNESP] |
author_facet |
Prata, Marcela Polachini [UNESP] Jaldin, Rodrigo Gibin [UNESP] Lourenção, Pedro Luiz Toledo de Arruda [UNESP] Sobreira, Marcone Lima [UNESP] Yoshida, Ricardo de Alvarenga [UNESP] Terra, Simone Antunes [UNESP] Viero, Rosa Marlene [UNESP] Yoshida, Winston Bonetti [UNESP] |
author_role |
author |
author2 |
Jaldin, Rodrigo Gibin [UNESP] Lourenção, Pedro Luiz Toledo de Arruda [UNESP] Sobreira, Marcone Lima [UNESP] Yoshida, Ricardo de Alvarenga [UNESP] Terra, Simone Antunes [UNESP] Viero, Rosa Marlene [UNESP] Yoshida, Winston Bonetti [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Prata, Marcela Polachini [UNESP] Jaldin, Rodrigo Gibin [UNESP] Lourenção, Pedro Luiz Toledo de Arruda [UNESP] Sobreira, Marcone Lima [UNESP] Yoshida, Ricardo de Alvarenga [UNESP] Terra, Simone Antunes [UNESP] Viero, Rosa Marlene [UNESP] Yoshida, Winston Bonetti [UNESP] |
dc.subject.por.fl_str_mv |
Abdominal aorta Mechanical stress Tensile strength Vascular closure devices |
topic |
Abdominal aorta Mechanical stress Tensile strength Vascular closure devices |
description |
Background: Aortic cross-clamping and balloon occlusion of the aorta could lead to damage to the aorta wall. Objective: The aim of this study was to investigate changes to the aorta wall related to the method used to interrupt flow (clamping or balloon) in the different techniques available for aortic surgery. Methods: Experiments were performed on 40 female pigs, weighing 25-30kg, which were randomly allocated to 4 study groups: S (n=10), no intervention (sham group); C (n=10), midline transperitoneal laparotomy for infrarenal abdominal aortic access with 60 min of cross-clamping; L (n=10), laparoscopic infrarenal abdominal aortic surgery with 60 min of cross-clamping; EV (n=10), remote proximal aortic control with transfemoral arterial insertion of aortic occlusion balloon catheter, inflated to provide continued aortic occlusion for 60min. After euthanasia, the aortas were removed and cross-sectioned to obtain histological specimens for light microscopic and morphometric analyses. The remaining longitudinal segments were stretched to rupture and mechanical parameters were determined. Results: We observed a reduction in the yield point of the abdominal aorta, decrease in stiffness and in failure load in the aortic cross-clamping groups (C and L) compared with the EV group. Conclusions: Aortic cross-clamping during open or laparoscopic surgery can affect the mechanical properties of the aorta leading to decrease in resistance of the aorta wall, without structural changes in aorta wall histology. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:41:08Z 2020-12-12T02:41:08Z 2020-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1677-5449.190025 Jornal Vascular Brasileiro, v. 19. 1677-7301 1677-5449 http://hdl.handle.net/11449/201762 10.1590/1677-5449.190025 S1677-54492020000100306 2-s2.0-85084843438 S1677-54492020000100306.pdf |
url |
http://dx.doi.org/10.1590/1677-5449.190025 http://hdl.handle.net/11449/201762 |
identifier_str_mv |
Jornal Vascular Brasileiro, v. 19. 1677-7301 1677-5449 10.1590/1677-5449.190025 S1677-54492020000100306 2-s2.0-85084843438 S1677-54492020000100306.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Jornal Vascular Brasileiro |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021374476943360 |