Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.5935/0103-5053.20150151 http://hdl.handle.net/11449/172068 |
Resumo: | Mebendazole (MBZ) is an anthelmintic medicine known to exhibit the polymorphs A, B and C, where polymorph C is the one indicated for tablets. Mebendazole commercial tablets (references, generics and similars) were analyzed in this work using X-ray powder diffraction data and the Rietveld method (RM) aiming at characterizing and quantifying crystal phases. Form C was found in mixture with form A in formulations of 500 mg (reference and generic). One of the generics presented a batch with form B and another one with form C. All the other tablets presented form A. |
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Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstoresMebendazolePolymorphismRietveld methodX-ray powder diffractometryMebendazole (MBZ) is an anthelmintic medicine known to exhibit the polymorphs A, B and C, where polymorph C is the one indicated for tablets. Mebendazole commercial tablets (references, generics and similars) were analyzed in this work using X-ray powder diffraction data and the Rietveld method (RM) aiming at characterizing and quantifying crystal phases. Form C was found in mixture with form A in formulations of 500 mg (reference and generic). One of the generics presented a batch with form B and another one with form C. All the other tablets presented form A.Departamento de Físico-Química, Instituto de Química, Universidade Estadual Paulista (UNESP), R. Prof. Francisco Degni, 55Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC (UFABC), Av. dos Estados, 5001Departamento de Físico-Química, Instituto de Química, Universidade Estadual Paulista (UNESP), R. Prof. Francisco Degni, 55Universidade Estadual Paulista (Unesp)Universidade Federal do ABC (UFABC)Salvi, Simone T. B. [UNESP]Antonio, Selma G. [UNESP]Ferreira, Fabio F.Paiva-Santos, Carlos O. [UNESP]2018-12-11T16:58:22Z2018-12-11T16:58:22Z2015-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1760-1768application/pdfhttp://dx.doi.org/10.5935/0103-5053.20150151Journal of the Brazilian Chemical Society, v. 26, n. 9, p. 1760-1768, 2015.1678-47900103-5053http://hdl.handle.net/11449/17206810.5935/0103-5053.20150151S0103-505320150009017602-s2.0-84941564408S0103-50532015000901760.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society0,3570,357info:eu-repo/semantics/openAccess2023-11-02T06:07:20Zoai:repositorio.unesp.br:11449/172068Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:42:16.310231Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores |
| title |
Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores |
| spellingShingle |
Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores Salvi, Simone T. B. [UNESP] Mebendazole Polymorphism Rietveld method X-ray powder diffractometry |
| title_short |
Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores |
| title_full |
Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores |
| title_fullStr |
Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores |
| title_full_unstemmed |
Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores |
| title_sort |
Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores |
| author |
Salvi, Simone T. B. [UNESP] |
| author_facet |
Salvi, Simone T. B. [UNESP] Antonio, Selma G. [UNESP] Ferreira, Fabio F. Paiva-Santos, Carlos O. [UNESP] |
| author_role |
author |
| author2 |
Antonio, Selma G. [UNESP] Ferreira, Fabio F. Paiva-Santos, Carlos O. [UNESP] |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal do ABC (UFABC) |
| dc.contributor.author.fl_str_mv |
Salvi, Simone T. B. [UNESP] Antonio, Selma G. [UNESP] Ferreira, Fabio F. Paiva-Santos, Carlos O. [UNESP] |
| dc.subject.por.fl_str_mv |
Mebendazole Polymorphism Rietveld method X-ray powder diffractometry |
| topic |
Mebendazole Polymorphism Rietveld method X-ray powder diffractometry |
| description |
Mebendazole (MBZ) is an anthelmintic medicine known to exhibit the polymorphs A, B and C, where polymorph C is the one indicated for tablets. Mebendazole commercial tablets (references, generics and similars) were analyzed in this work using X-ray powder diffraction data and the Rietveld method (RM) aiming at characterizing and quantifying crystal phases. Form C was found in mixture with form A in formulations of 500 mg (reference and generic). One of the generics presented a batch with form B and another one with form C. All the other tablets presented form A. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-09-01 2018-12-11T16:58:22Z 2018-12-11T16:58:22Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5935/0103-5053.20150151 Journal of the Brazilian Chemical Society, v. 26, n. 9, p. 1760-1768, 2015. 1678-4790 0103-5053 http://hdl.handle.net/11449/172068 10.5935/0103-5053.20150151 S0103-50532015000901760 2-s2.0-84941564408 S0103-50532015000901760.pdf |
| url |
http://dx.doi.org/10.5935/0103-5053.20150151 http://hdl.handle.net/11449/172068 |
| identifier_str_mv |
Journal of the Brazilian Chemical Society, v. 26, n. 9, p. 1760-1768, 2015. 1678-4790 0103-5053 10.5935/0103-5053.20150151 S0103-50532015000901760 2-s2.0-84941564408 S0103-50532015000901760.pdf |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal of the Brazilian Chemical Society 0,357 0,357 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
1760-1768 application/pdf |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
| institution |
UNESP |
| reponame_str |
Repositório Institucional da UNESP |
| collection |
Repositório Institucional da UNESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1808128688986783744 |