Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000200005 |
Resumo: | This study evaluates the incidence of the polymorphic forms of mebendazole (MBZ) in tablets within the Brazilian market by dissolution tests. The indicated dissolution medium by the USP 30 (United States Pharmacopoeia) and a proposed modified medium were duly compared in order to verify whether they are able to discriminate the polymorph A from polymorph C in commercial tablets. Dissolution assay tests of physical mixtures in raw materials of polymorph A and polymorph C, as well as of nine tablets of MBZ (available in the Brazilian market), were properly performed. For the dissolution tests, the USP 30 medium (I) and a modified medium (II) were used. The modified medium allowed a reproducible and reliable quality control of MBZ polymorphism in commercial tablets. |
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Polymorphism evaluation in generic tablets containing mebendazole by dissolution testsmebendazolepolymorphismsolubilityRaman spectroscopyX-ray powder diffractionThis study evaluates the incidence of the polymorphic forms of mebendazole (MBZ) in tablets within the Brazilian market by dissolution tests. The indicated dissolution medium by the USP 30 (United States Pharmacopoeia) and a proposed modified medium were duly compared in order to verify whether they are able to discriminate the polymorph A from polymorph C in commercial tablets. Dissolution assay tests of physical mixtures in raw materials of polymorph A and polymorph C, as well as of nine tablets of MBZ (available in the Brazilian market), were properly performed. For the dissolution tests, the USP 30 medium (I) and a modified medium (II) were used. The modified medium allowed a reproducible and reliable quality control of MBZ polymorphism in commercial tablets.Sociedade Brasileira de Química2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000200005Journal of the Brazilian Chemical Society v.23 n.2 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012000200005info:eu-repo/semantics/openAccessHonorato,Sara B.Farfan,SilviaViana,ArnaldoFilho,Josué M.Camarão,Gisela C.Fechine,Francisco V.Moraes,Maria E. A.Moraes,Manoel O.Ferro,MaribelDabbene,VivianaCuffini,Silvia L.Ayala,Alejandro P.eng2012-03-02T00:00:00Zoai:scielo:S0103-50532012000200005Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-03-02T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests |
title |
Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests |
spellingShingle |
Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests Honorato,Sara B. mebendazole polymorphism solubility Raman spectroscopy X-ray powder diffraction |
title_short |
Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests |
title_full |
Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests |
title_fullStr |
Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests |
title_full_unstemmed |
Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests |
title_sort |
Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests |
author |
Honorato,Sara B. |
author_facet |
Honorato,Sara B. Farfan,Silvia Viana,Arnaldo Filho,Josué M. Camarão,Gisela C. Fechine,Francisco V. Moraes,Maria E. A. Moraes,Manoel O. Ferro,Maribel Dabbene,Viviana Cuffini,Silvia L. Ayala,Alejandro P. |
author_role |
author |
author2 |
Farfan,Silvia Viana,Arnaldo Filho,Josué M. Camarão,Gisela C. Fechine,Francisco V. Moraes,Maria E. A. Moraes,Manoel O. Ferro,Maribel Dabbene,Viviana Cuffini,Silvia L. Ayala,Alejandro P. |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Honorato,Sara B. Farfan,Silvia Viana,Arnaldo Filho,Josué M. Camarão,Gisela C. Fechine,Francisco V. Moraes,Maria E. A. Moraes,Manoel O. Ferro,Maribel Dabbene,Viviana Cuffini,Silvia L. Ayala,Alejandro P. |
dc.subject.por.fl_str_mv |
mebendazole polymorphism solubility Raman spectroscopy X-ray powder diffraction |
topic |
mebendazole polymorphism solubility Raman spectroscopy X-ray powder diffraction |
description |
This study evaluates the incidence of the polymorphic forms of mebendazole (MBZ) in tablets within the Brazilian market by dissolution tests. The indicated dissolution medium by the USP 30 (United States Pharmacopoeia) and a proposed modified medium were duly compared in order to verify whether they are able to discriminate the polymorph A from polymorph C in commercial tablets. Dissolution assay tests of physical mixtures in raw materials of polymorph A and polymorph C, as well as of nine tablets of MBZ (available in the Brazilian market), were properly performed. For the dissolution tests, the USP 30 medium (I) and a modified medium (II) were used. The modified medium allowed a reproducible and reliable quality control of MBZ polymorphism in commercial tablets. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000200005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000200005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532012000200005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.23 n.2 2012 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318173079470080 |