Development and evaluation of praziquantel solid dispersions in sodium starch glycolate

Detalhes bibliográficos
Autor(a) principal: Chaud, Marco V.
Data de Publicação: 2013
Outros Autores: Lima, Andréa C., Vila, Marta M.D.C., Paganelli, Maria O., Paula, Fábio C., Pedreiro, Liliane N., Gremião, Maria P.D. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.4314/tjpr.v12i2.5
http://hdl.handle.net/11449/75036
Resumo: Purpose: To develop and characterize solid dispersions of praziquantel (PZQ) with sodium starch glycolate (SSG) for enhanced drug solubility. Methods: PZQ solid dispersion (SD) was prepared using co-precipitation method by solvent evaporation. The ratios of PZQ to SSG were 2:1, 1:1, 1:2, 1:3 (w/w). PZQ solubility was evaluated in purified water, and PZQ dissolution test was carried out in 0.1N HCl. Structural characterization of the dispersions was accomplished by x-ray diffraction (XRD) and infrared spectroscopy (FTIR) while the external morphology of the SDs, SSG and PZQ were studied by scanning electron microscopy (SEM). Mucoadhesion properties of the SD (1:3) and SSG, on mucin disks were examined using texture profile analysis. Results: The highest solubility was obtained with 1:3 solid dispersion, with PZQ solubility of 97.31 %, which is 3.65-fold greater than the solubility of pure PZQ and physical misture (PM, 1:3). XRD results indicate a reduction in PZQ crystallinity while infrared spectra showed that the functional groups of PZQ and SSG were preserved. SEM showed that the physical structure of PZQ was modified from crystalline to amorphous. The amount of PZQ in PM and SD (1:3) that dissolved in 60 min was 70 and 88 %, respectively, and these values increased to 76 and 96 %, respectively. The solid dispersion reduced the mucoadhesive property of the glycolate. Conclusion: Solid dispersion formulation using SSG is a good alternative approach for increasing the dissolution rate of PZQ. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.
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spelling Development and evaluation of praziquantel solid dispersions in sodium starch glycolateCo-precipitationDrug bioavailabilityPraziquantelSchistosomiasisSodium starch glycolateSolid dispersionhydrochloric acidmucinpraziquantelsolventstarch glycolate sodiumwatercrystal structuredispersiondrug bioavailabilitydrug releasedrug screeningdrug solubilitydrug structureevaporationin vitro studyinfrared spectroscopymucoadhesionprecipitationscanning electron microscopyX ray diffractionPurpose: To develop and characterize solid dispersions of praziquantel (PZQ) with sodium starch glycolate (SSG) for enhanced drug solubility. Methods: PZQ solid dispersion (SD) was prepared using co-precipitation method by solvent evaporation. The ratios of PZQ to SSG were 2:1, 1:1, 1:2, 1:3 (w/w). PZQ solubility was evaluated in purified water, and PZQ dissolution test was carried out in 0.1N HCl. Structural characterization of the dispersions was accomplished by x-ray diffraction (XRD) and infrared spectroscopy (FTIR) while the external morphology of the SDs, SSG and PZQ were studied by scanning electron microscopy (SEM). Mucoadhesion properties of the SD (1:3) and SSG, on mucin disks were examined using texture profile analysis. Results: The highest solubility was obtained with 1:3 solid dispersion, with PZQ solubility of 97.31 %, which is 3.65-fold greater than the solubility of pure PZQ and physical misture (PM, 1:3). XRD results indicate a reduction in PZQ crystallinity while infrared spectra showed that the functional groups of PZQ and SSG were preserved. SEM showed that the physical structure of PZQ was modified from crystalline to amorphous. The amount of PZQ in PM and SD (1:3) that dissolved in 60 min was 70 and 88 %, respectively, and these values increased to 76 and 96 %, respectively. The solid dispersion reduced the mucoadhesive property of the glycolate. Conclusion: Solid dispersion formulation using SSG is a good alternative approach for increasing the dissolution rate of PZQ. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.Laboratory for Development and Evaluation of Bioactive Substances Sorocaba University (UNISO), Sorocaba, SPPiracicaba Methodist University, Piracicaba, SPCampinas University UNICAMP, Campinas, SPRibeirão Preto University (UNAERP), Ribeirão Preto-SPSão Paulo State University UNESP, Araraquara, SPSão Paulo State University UNESP, Araraquara, SPSorocaba University (UNISO)Piracicaba Methodist UniversityUniversidade Estadual de Campinas (UNICAMP)Ribeirão Preto University (UNAERP)Universidade Estadual Paulista (Unesp)Chaud, Marco V.Lima, Andréa C.Vila, Marta M.D.C.Paganelli, Maria O.Paula, Fábio C.Pedreiro, Liliane N.Gremião, Maria P.D. [UNESP]2014-05-27T11:28:49Z2014-05-27T11:28:49Z2013-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article163-168application/pdfhttp://dx.doi.org/10.4314/tjpr.v12i2.5Tropical Journal of Pharmaceutical Research, v. 12, n. 2, p. 163-168, 2013.1596-59961596-9827http://hdl.handle.net/11449/7503610.4314/tjpr.v12i2.5WOS:0003186728000052-s2.0-848769413392-s2.0-84876941339.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTropical Journal of Pharmaceutical Research0.4440,256info:eu-repo/semantics/openAccess2024-06-24T13:45:39Zoai:repositorio.unesp.br:11449/75036Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:13:00.019246Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Development and evaluation of praziquantel solid dispersions in sodium starch glycolate
title Development and evaluation of praziquantel solid dispersions in sodium starch glycolate
spellingShingle Development and evaluation of praziquantel solid dispersions in sodium starch glycolate
Chaud, Marco V.
Co-precipitation
Drug bioavailability
Praziquantel
Schistosomiasis
Sodium starch glycolate
Solid dispersion
hydrochloric acid
mucin
praziquantel
solvent
starch glycolate sodium
water
crystal structure
dispersion
drug bioavailability
drug release
drug screening
drug solubility
drug structure
evaporation
in vitro study
infrared spectroscopy
mucoadhesion
precipitation
scanning electron microscopy
X ray diffraction
title_short Development and evaluation of praziquantel solid dispersions in sodium starch glycolate
title_full Development and evaluation of praziquantel solid dispersions in sodium starch glycolate
title_fullStr Development and evaluation of praziquantel solid dispersions in sodium starch glycolate
title_full_unstemmed Development and evaluation of praziquantel solid dispersions in sodium starch glycolate
title_sort Development and evaluation of praziquantel solid dispersions in sodium starch glycolate
author Chaud, Marco V.
author_facet Chaud, Marco V.
Lima, Andréa C.
Vila, Marta M.D.C.
Paganelli, Maria O.
Paula, Fábio C.
Pedreiro, Liliane N.
Gremião, Maria P.D. [UNESP]
author_role author
author2 Lima, Andréa C.
Vila, Marta M.D.C.
Paganelli, Maria O.
Paula, Fábio C.
Pedreiro, Liliane N.
Gremião, Maria P.D. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sorocaba University (UNISO)
Piracicaba Methodist University
Universidade Estadual de Campinas (UNICAMP)
Ribeirão Preto University (UNAERP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Chaud, Marco V.
Lima, Andréa C.
Vila, Marta M.D.C.
Paganelli, Maria O.
Paula, Fábio C.
Pedreiro, Liliane N.
Gremião, Maria P.D. [UNESP]
dc.subject.por.fl_str_mv Co-precipitation
Drug bioavailability
Praziquantel
Schistosomiasis
Sodium starch glycolate
Solid dispersion
hydrochloric acid
mucin
praziquantel
solvent
starch glycolate sodium
water
crystal structure
dispersion
drug bioavailability
drug release
drug screening
drug solubility
drug structure
evaporation
in vitro study
infrared spectroscopy
mucoadhesion
precipitation
scanning electron microscopy
X ray diffraction
topic Co-precipitation
Drug bioavailability
Praziquantel
Schistosomiasis
Sodium starch glycolate
Solid dispersion
hydrochloric acid
mucin
praziquantel
solvent
starch glycolate sodium
water
crystal structure
dispersion
drug bioavailability
drug release
drug screening
drug solubility
drug structure
evaporation
in vitro study
infrared spectroscopy
mucoadhesion
precipitation
scanning electron microscopy
X ray diffraction
description Purpose: To develop and characterize solid dispersions of praziquantel (PZQ) with sodium starch glycolate (SSG) for enhanced drug solubility. Methods: PZQ solid dispersion (SD) was prepared using co-precipitation method by solvent evaporation. The ratios of PZQ to SSG were 2:1, 1:1, 1:2, 1:3 (w/w). PZQ solubility was evaluated in purified water, and PZQ dissolution test was carried out in 0.1N HCl. Structural characterization of the dispersions was accomplished by x-ray diffraction (XRD) and infrared spectroscopy (FTIR) while the external morphology of the SDs, SSG and PZQ were studied by scanning electron microscopy (SEM). Mucoadhesion properties of the SD (1:3) and SSG, on mucin disks were examined using texture profile analysis. Results: The highest solubility was obtained with 1:3 solid dispersion, with PZQ solubility of 97.31 %, which is 3.65-fold greater than the solubility of pure PZQ and physical misture (PM, 1:3). XRD results indicate a reduction in PZQ crystallinity while infrared spectra showed that the functional groups of PZQ and SSG were preserved. SEM showed that the physical structure of PZQ was modified from crystalline to amorphous. The amount of PZQ in PM and SD (1:3) that dissolved in 60 min was 70 and 88 %, respectively, and these values increased to 76 and 96 %, respectively. The solid dispersion reduced the mucoadhesive property of the glycolate. Conclusion: Solid dispersion formulation using SSG is a good alternative approach for increasing the dissolution rate of PZQ. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-01
2014-05-27T11:28:49Z
2014-05-27T11:28:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4314/tjpr.v12i2.5
Tropical Journal of Pharmaceutical Research, v. 12, n. 2, p. 163-168, 2013.
1596-5996
1596-9827
http://hdl.handle.net/11449/75036
10.4314/tjpr.v12i2.5
WOS:000318672800005
2-s2.0-84876941339
2-s2.0-84876941339.pdf
url http://dx.doi.org/10.4314/tjpr.v12i2.5
http://hdl.handle.net/11449/75036
identifier_str_mv Tropical Journal of Pharmaceutical Research, v. 12, n. 2, p. 163-168, 2013.
1596-5996
1596-9827
10.4314/tjpr.v12i2.5
WOS:000318672800005
2-s2.0-84876941339
2-s2.0-84876941339.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Tropical Journal of Pharmaceutical Research
0.444
0,256
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 163-168
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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