In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug

Detalhes bibliográficos
Autor(a) principal: Silveira, C. P.
Data de Publicação: 2015
Outros Autores: Paula, A. J., Apoliná Rio, L. M. [UNESP], Fávaro, W. J. [UNESP], Durán, N.
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1088/1742-6596/617/1/012024
http://hdl.handle.net/11449/168403
Resumo: One of the major problems in cancer therapies is the high occurrence of side effects intrinsic of anticancer drugs. Doxorrubicin is a conventional anticancer molecule used to treat a wide range of cancer, such as breast, ovarian and prostate. However, its use is associated with a number of side effects like multidrug resistance and cardiotoxicity. The association with nanomaterials has been considered in the past decade to overcome the high toxicity of these drugs. In this context, mesoporous silica nanoparticles are great candidates to be used as carriers once they are very biocompatible. Taking into account the combination of nanoparticles and doxorrubicin, we treated rats with chemically induced prostate cancer with systems based on mesoporous silica nanoparticles and a thermoreversible block copolymer (Pluronic F-127) containing doxorrubicin. Preliminary results show a possible improvement in tumor conditions proportional to the concentration of the nanoparticles, opening a perspective to use mesoporous silica nanoparticles as carrier for doxorrubicin in prostate cancer treatment.
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spelling In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drugOne of the major problems in cancer therapies is the high occurrence of side effects intrinsic of anticancer drugs. Doxorrubicin is a conventional anticancer molecule used to treat a wide range of cancer, such as breast, ovarian and prostate. However, its use is associated with a number of side effects like multidrug resistance and cardiotoxicity. The association with nanomaterials has been considered in the past decade to overcome the high toxicity of these drugs. In this context, mesoporous silica nanoparticles are great candidates to be used as carriers once they are very biocompatible. Taking into account the combination of nanoparticles and doxorrubicin, we treated rats with chemically induced prostate cancer with systems based on mesoporous silica nanoparticles and a thermoreversible block copolymer (Pluronic F-127) containing doxorrubicin. Preliminary results show a possible improvement in tumor conditions proportional to the concentration of the nanoparticles, opening a perspective to use mesoporous silica nanoparticles as carrier for doxorrubicin in prostate cancer treatment.Chemistry Institute Universitáde Estadual de Campinas (UNICAMP) Campus Universitário Zeferino Vaz, s/n, Cidade UniversitáriaDepartment of Physics Universidade Federal Do Ceará (UFC), Avenida da Universidade, Benfica, CEP 60020-181, CEDepartment of Environmental Engineering Universidade Estadual Paulista (UNESP), Avenida Trěs de Março, CEP 18087-180, SPFarmabrasilis R and D DivisionNanobioss Laboratory Chemistry Institute Universidade Estadual de Campinas (UNICAMP) Campus Universitário Zeferino Vaz, s/n, Cidade UniversitáriaDepartment of Environmental Engineering Universidade Estadual Paulista (UNESP), Avenida Trěs de Março, CEP 18087-180, SPUniversidade Estadual de Campinas (UNICAMP)Universidade Federal Do Ceará (UFC)Universidade Estadual Paulista (Unesp)Farmabrasilis R and D DivisionSilveira, C. P.Paula, A. J.Apoliná Rio, L. M. [UNESP]Fávaro, W. J. [UNESP]Durán, N.2018-12-11T16:41:07Z2018-12-11T16:41:07Z2015-05-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectapplication/pdfhttp://dx.doi.org/10.1088/1742-6596/617/1/012024Journal of Physics: Conference Series, v. 617, n. 1, 2015.1742-65961742-6588http://hdl.handle.net/11449/16840310.1088/1742-6596/617/1/0120242-s2.0-849586368042-s2.0-84958636804.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Physics: Conference Series0,2410,241info:eu-repo/semantics/openAccess2023-11-07T06:15:51Zoai:repositorio.unesp.br:11449/168403Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:07:21.793535Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug
title In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug
spellingShingle In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug
Silveira, C. P.
title_short In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug
title_full In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug
title_fullStr In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug
title_full_unstemmed In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug
title_sort In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug
author Silveira, C. P.
author_facet Silveira, C. P.
Paula, A. J.
Apoliná Rio, L. M. [UNESP]
Fávaro, W. J. [UNESP]
Durán, N.
author_role author
author2 Paula, A. J.
Apoliná Rio, L. M. [UNESP]
Fávaro, W. J. [UNESP]
Durán, N.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Federal Do Ceará (UFC)
Universidade Estadual Paulista (Unesp)
Farmabrasilis R and D Division
dc.contributor.author.fl_str_mv Silveira, C. P.
Paula, A. J.
Apoliná Rio, L. M. [UNESP]
Fávaro, W. J. [UNESP]
Durán, N.
description One of the major problems in cancer therapies is the high occurrence of side effects intrinsic of anticancer drugs. Doxorrubicin is a conventional anticancer molecule used to treat a wide range of cancer, such as breast, ovarian and prostate. However, its use is associated with a number of side effects like multidrug resistance and cardiotoxicity. The association with nanomaterials has been considered in the past decade to overcome the high toxicity of these drugs. In this context, mesoporous silica nanoparticles are great candidates to be used as carriers once they are very biocompatible. Taking into account the combination of nanoparticles and doxorrubicin, we treated rats with chemically induced prostate cancer with systems based on mesoporous silica nanoparticles and a thermoreversible block copolymer (Pluronic F-127) containing doxorrubicin. Preliminary results show a possible improvement in tumor conditions proportional to the concentration of the nanoparticles, opening a perspective to use mesoporous silica nanoparticles as carrier for doxorrubicin in prostate cancer treatment.
publishDate 2015
dc.date.none.fl_str_mv 2015-05-26
2018-12-11T16:41:07Z
2018-12-11T16:41:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1088/1742-6596/617/1/012024
Journal of Physics: Conference Series, v. 617, n. 1, 2015.
1742-6596
1742-6588
http://hdl.handle.net/11449/168403
10.1088/1742-6596/617/1/012024
2-s2.0-84958636804
2-s2.0-84958636804.pdf
url http://dx.doi.org/10.1088/1742-6596/617/1/012024
http://hdl.handle.net/11449/168403
identifier_str_mv Journal of Physics: Conference Series, v. 617, n. 1, 2015.
1742-6596
1742-6588
10.1088/1742-6596/617/1/012024
2-s2.0-84958636804
2-s2.0-84958636804.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Physics: Conference Series
0,241
0,241
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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