In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1088/1742-6596/617/1/012024 http://hdl.handle.net/11449/168403 |
Resumo: | One of the major problems in cancer therapies is the high occurrence of side effects intrinsic of anticancer drugs. Doxorrubicin is a conventional anticancer molecule used to treat a wide range of cancer, such as breast, ovarian and prostate. However, its use is associated with a number of side effects like multidrug resistance and cardiotoxicity. The association with nanomaterials has been considered in the past decade to overcome the high toxicity of these drugs. In this context, mesoporous silica nanoparticles are great candidates to be used as carriers once they are very biocompatible. Taking into account the combination of nanoparticles and doxorrubicin, we treated rats with chemically induced prostate cancer with systems based on mesoporous silica nanoparticles and a thermoreversible block copolymer (Pluronic F-127) containing doxorrubicin. Preliminary results show a possible improvement in tumor conditions proportional to the concentration of the nanoparticles, opening a perspective to use mesoporous silica nanoparticles as carrier for doxorrubicin in prostate cancer treatment. |
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In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drugOne of the major problems in cancer therapies is the high occurrence of side effects intrinsic of anticancer drugs. Doxorrubicin is a conventional anticancer molecule used to treat a wide range of cancer, such as breast, ovarian and prostate. However, its use is associated with a number of side effects like multidrug resistance and cardiotoxicity. The association with nanomaterials has been considered in the past decade to overcome the high toxicity of these drugs. In this context, mesoporous silica nanoparticles are great candidates to be used as carriers once they are very biocompatible. Taking into account the combination of nanoparticles and doxorrubicin, we treated rats with chemically induced prostate cancer with systems based on mesoporous silica nanoparticles and a thermoreversible block copolymer (Pluronic F-127) containing doxorrubicin. Preliminary results show a possible improvement in tumor conditions proportional to the concentration of the nanoparticles, opening a perspective to use mesoporous silica nanoparticles as carrier for doxorrubicin in prostate cancer treatment.Chemistry Institute Universitáde Estadual de Campinas (UNICAMP) Campus Universitário Zeferino Vaz, s/n, Cidade UniversitáriaDepartment of Physics Universidade Federal Do Ceará (UFC), Avenida da Universidade, Benfica, CEP 60020-181, CEDepartment of Environmental Engineering Universidade Estadual Paulista (UNESP), Avenida Trěs de Março, CEP 18087-180, SPFarmabrasilis R and D DivisionNanobioss Laboratory Chemistry Institute Universidade Estadual de Campinas (UNICAMP) Campus Universitário Zeferino Vaz, s/n, Cidade UniversitáriaDepartment of Environmental Engineering Universidade Estadual Paulista (UNESP), Avenida Trěs de Março, CEP 18087-180, SPUniversidade Estadual de Campinas (UNICAMP)Universidade Federal Do Ceará (UFC)Universidade Estadual Paulista (Unesp)Farmabrasilis R and D DivisionSilveira, C. P.Paula, A. J.Apoliná Rio, L. M. [UNESP]Fávaro, W. J. [UNESP]Durán, N.2018-12-11T16:41:07Z2018-12-11T16:41:07Z2015-05-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectapplication/pdfhttp://dx.doi.org/10.1088/1742-6596/617/1/012024Journal of Physics: Conference Series, v. 617, n. 1, 2015.1742-65961742-6588http://hdl.handle.net/11449/16840310.1088/1742-6596/617/1/0120242-s2.0-849586368042-s2.0-84958636804.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Physics: Conference Series0,2410,241info:eu-repo/semantics/openAccess2023-11-07T06:15:51Zoai:repositorio.unesp.br:11449/168403Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:07:21.793535Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug |
title |
In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug |
spellingShingle |
In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug Silveira, C. P. |
title_short |
In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug |
title_full |
In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug |
title_fullStr |
In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug |
title_full_unstemmed |
In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug |
title_sort |
In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug |
author |
Silveira, C. P. |
author_facet |
Silveira, C. P. Paula, A. J. Apoliná Rio, L. M. [UNESP] Fávaro, W. J. [UNESP] Durán, N. |
author_role |
author |
author2 |
Paula, A. J. Apoliná Rio, L. M. [UNESP] Fávaro, W. J. [UNESP] Durán, N. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Federal Do Ceará (UFC) Universidade Estadual Paulista (Unesp) Farmabrasilis R and D Division |
dc.contributor.author.fl_str_mv |
Silveira, C. P. Paula, A. J. Apoliná Rio, L. M. [UNESP] Fávaro, W. J. [UNESP] Durán, N. |
description |
One of the major problems in cancer therapies is the high occurrence of side effects intrinsic of anticancer drugs. Doxorrubicin is a conventional anticancer molecule used to treat a wide range of cancer, such as breast, ovarian and prostate. However, its use is associated with a number of side effects like multidrug resistance and cardiotoxicity. The association with nanomaterials has been considered in the past decade to overcome the high toxicity of these drugs. In this context, mesoporous silica nanoparticles are great candidates to be used as carriers once they are very biocompatible. Taking into account the combination of nanoparticles and doxorrubicin, we treated rats with chemically induced prostate cancer with systems based on mesoporous silica nanoparticles and a thermoreversible block copolymer (Pluronic F-127) containing doxorrubicin. Preliminary results show a possible improvement in tumor conditions proportional to the concentration of the nanoparticles, opening a perspective to use mesoporous silica nanoparticles as carrier for doxorrubicin in prostate cancer treatment. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-05-26 2018-12-11T16:41:07Z 2018-12-11T16:41:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1088/1742-6596/617/1/012024 Journal of Physics: Conference Series, v. 617, n. 1, 2015. 1742-6596 1742-6588 http://hdl.handle.net/11449/168403 10.1088/1742-6596/617/1/012024 2-s2.0-84958636804 2-s2.0-84958636804.pdf |
url |
http://dx.doi.org/10.1088/1742-6596/617/1/012024 http://hdl.handle.net/11449/168403 |
identifier_str_mv |
Journal of Physics: Conference Series, v. 617, n. 1, 2015. 1742-6596 1742-6588 10.1088/1742-6596/617/1/012024 2-s2.0-84958636804 2-s2.0-84958636804.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Physics: Conference Series 0,241 0,241 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128757590917120 |