Antarctic environments as a source of bacterial and fungal therapeutic enzymes

Detalhes bibliográficos
Autor(a) principal: Lima, Igor G. O.
Data de Publicação: 2022
Outros Autores: Bispo, James R. S., Agostinho, Adson Y. H., De Queiroz, Aline C., Moreira, Magna Suzana A., Passarini, Michel Rodrigo Z., De Oliveira, Valéria M., Sette, Lara D. [UNESP], Rosa, Luiz Henrique, Duarte, Alysson Wagner F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/0001-3765202220210452
http://hdl.handle.net/11449/223471
Resumo: Microbial therapeutic enzymes are the protagonists in the pharmacological treatment of different human diseases. The intrinsic enzymatic characteristics, such as high affinity and specificity to the corresponding substrate, enable effective therapies, with minimal adverse effects and complete remission. However, immunogenicity, short half-life, low enzymatic yield, and low selectivity regarding available enzyme drugs are currently the main obstacles to their development and the broad adherence to therapeutic protocols. By harboring adapted and still unexplored microbial life, environments of extreme conditions, such as Antarctica, become especially important in the prospecting and development of new enzymatic compounds that present higher yields and the possibility of genetic improvement. Antarctic microorganisms have adaptation mechanisms, such as more fluid cell membranes, production of antifreeze proteins and enzymes with more malleable structures, more robust, stable, selective catalytic sites for their respective substrates, and high antioxidant capacity. In this context, this review aims to explore enzymes synthesized by bacteria and fungi from Antarctica as potential drug producers, capable of providing therapeutic efficacy, less adverse effects, and lower production costs with highlight to L-Asparaginase, collagenase, superoxide dismutase and ribonucleases. In addition, this review highlights the unique biotechnological profile of these Antarctic extremophile microorganisms.
id UNSP_4eb9bcaf41952f672898c134d9acaeca
oai_identifier_str oai:repositorio.unesp.br:11449/223471
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Antarctic environments as a source of bacterial and fungal therapeutic enzymesAntarcticaCollagenaseExtremophilesL-AsparaginaseSuperoxide dismutaseTherapeutics enzymesMicrobial therapeutic enzymes are the protagonists in the pharmacological treatment of different human diseases. The intrinsic enzymatic characteristics, such as high affinity and specificity to the corresponding substrate, enable effective therapies, with minimal adverse effects and complete remission. However, immunogenicity, short half-life, low enzymatic yield, and low selectivity regarding available enzyme drugs are currently the main obstacles to their development and the broad adherence to therapeutic protocols. By harboring adapted and still unexplored microbial life, environments of extreme conditions, such as Antarctica, become especially important in the prospecting and development of new enzymatic compounds that present higher yields and the possibility of genetic improvement. Antarctic microorganisms have adaptation mechanisms, such as more fluid cell membranes, production of antifreeze proteins and enzymes with more malleable structures, more robust, stable, selective catalytic sites for their respective substrates, and high antioxidant capacity. In this context, this review aims to explore enzymes synthesized by bacteria and fungi from Antarctica as potential drug producers, capable of providing therapeutic efficacy, less adverse effects, and lower production costs with highlight to L-Asparaginase, collagenase, superoxide dismutase and ribonucleases. In addition, this review highlights the unique biotechnological profile of these Antarctic extremophile microorganisms.Universidade Federal de Alagoas Complexo de Ciências Médicas e Enfermagem, Campus Arapiraca, Av. Manoel Severino Barbosa, s/n, Bom SucessoUniversidade Federal de Alagoas Instituto de Ciências Biológicas e da Saúde, Av. Lourival Melo Mota, s/n, Tabuleiro do MartinsUniversidade Federal da Integração Latino-Americana, Av. Silvio Américo Sasdelli, 1842, Itaipú AUniversidade Estadual de Campinas Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrárias, R. Alexandre Cazellato, 999, BetelDepartamento de Biologia Geral e Aplicada Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho, Av. 24 A, 1515, Bela VistaUniversidade Federal de Minas Gerais Instituto de Ciências Biológicas, Av. Presidente Antônio Carlos, 6627, PampulhaDepartamento de Biologia Geral e Aplicada Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho, Av. 24 A, 1515, Bela VistaComplexo de Ciências Médicas e EnfermagemInstituto de Ciências Biológicas e da SaúdeUniversidade Federal da Integração Latino-AmericanaUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Universidade Federal de Minas Gerais (UFMG)Lima, Igor G. O.Bispo, James R. S.Agostinho, Adson Y. H.De Queiroz, Aline C.Moreira, Magna Suzana A.Passarini, Michel Rodrigo Z.De Oliveira, Valéria M.Sette, Lara D. [UNESP]Rosa, Luiz HenriqueDuarte, Alysson Wagner F.2022-04-28T19:50:50Z2022-04-28T19:50:50Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/0001-3765202220210452Anais da Academia Brasileira de Ciencias, v. 94.1678-26900001-3765http://hdl.handle.net/11449/22347110.1590/0001-37652022202104522-s2.0-85124679950Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais da Academia Brasileira de Cienciasinfo:eu-repo/semantics/openAccess2022-04-28T19:50:50Zoai:repositorio.unesp.br:11449/223471Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:26:09.894588Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antarctic environments as a source of bacterial and fungal therapeutic enzymes
title Antarctic environments as a source of bacterial and fungal therapeutic enzymes
spellingShingle Antarctic environments as a source of bacterial and fungal therapeutic enzymes
Lima, Igor G. O.
Antarctica
Collagenase
Extremophiles
L-Asparaginase
Superoxide dismutase
Therapeutics enzymes
title_short Antarctic environments as a source of bacterial and fungal therapeutic enzymes
title_full Antarctic environments as a source of bacterial and fungal therapeutic enzymes
title_fullStr Antarctic environments as a source of bacterial and fungal therapeutic enzymes
title_full_unstemmed Antarctic environments as a source of bacterial and fungal therapeutic enzymes
title_sort Antarctic environments as a source of bacterial and fungal therapeutic enzymes
author Lima, Igor G. O.
author_facet Lima, Igor G. O.
Bispo, James R. S.
Agostinho, Adson Y. H.
De Queiroz, Aline C.
Moreira, Magna Suzana A.
Passarini, Michel Rodrigo Z.
De Oliveira, Valéria M.
Sette, Lara D. [UNESP]
Rosa, Luiz Henrique
Duarte, Alysson Wagner F.
author_role author
author2 Bispo, James R. S.
Agostinho, Adson Y. H.
De Queiroz, Aline C.
Moreira, Magna Suzana A.
Passarini, Michel Rodrigo Z.
De Oliveira, Valéria M.
Sette, Lara D. [UNESP]
Rosa, Luiz Henrique
Duarte, Alysson Wagner F.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Complexo de Ciências Médicas e Enfermagem
Instituto de Ciências Biológicas e da Saúde
Universidade Federal da Integração Latino-Americana
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (UNESP)
Universidade Federal de Minas Gerais (UFMG)
dc.contributor.author.fl_str_mv Lima, Igor G. O.
Bispo, James R. S.
Agostinho, Adson Y. H.
De Queiroz, Aline C.
Moreira, Magna Suzana A.
Passarini, Michel Rodrigo Z.
De Oliveira, Valéria M.
Sette, Lara D. [UNESP]
Rosa, Luiz Henrique
Duarte, Alysson Wagner F.
dc.subject.por.fl_str_mv Antarctica
Collagenase
Extremophiles
L-Asparaginase
Superoxide dismutase
Therapeutics enzymes
topic Antarctica
Collagenase
Extremophiles
L-Asparaginase
Superoxide dismutase
Therapeutics enzymes
description Microbial therapeutic enzymes are the protagonists in the pharmacological treatment of different human diseases. The intrinsic enzymatic characteristics, such as high affinity and specificity to the corresponding substrate, enable effective therapies, with minimal adverse effects and complete remission. However, immunogenicity, short half-life, low enzymatic yield, and low selectivity regarding available enzyme drugs are currently the main obstacles to their development and the broad adherence to therapeutic protocols. By harboring adapted and still unexplored microbial life, environments of extreme conditions, such as Antarctica, become especially important in the prospecting and development of new enzymatic compounds that present higher yields and the possibility of genetic improvement. Antarctic microorganisms have adaptation mechanisms, such as more fluid cell membranes, production of antifreeze proteins and enzymes with more malleable structures, more robust, stable, selective catalytic sites for their respective substrates, and high antioxidant capacity. In this context, this review aims to explore enzymes synthesized by bacteria and fungi from Antarctica as potential drug producers, capable of providing therapeutic efficacy, less adverse effects, and lower production costs with highlight to L-Asparaginase, collagenase, superoxide dismutase and ribonucleases. In addition, this review highlights the unique biotechnological profile of these Antarctic extremophile microorganisms.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-28T19:50:50Z
2022-04-28T19:50:50Z
2022-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/0001-3765202220210452
Anais da Academia Brasileira de Ciencias, v. 94.
1678-2690
0001-3765
http://hdl.handle.net/11449/223471
10.1590/0001-3765202220210452
2-s2.0-85124679950
url http://dx.doi.org/10.1590/0001-3765202220210452
http://hdl.handle.net/11449/223471
identifier_str_mv Anais da Academia Brasileira de Ciencias, v. 94.
1678-2690
0001-3765
10.1590/0001-3765202220210452
2-s2.0-85124679950
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais da Academia Brasileira de Ciencias
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129320254701568