Antarctic environments as a source of bacterial and fungal therapeutic enzymes
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0001-3765202220210452 http://hdl.handle.net/11449/223471 |
Resumo: | Microbial therapeutic enzymes are the protagonists in the pharmacological treatment of different human diseases. The intrinsic enzymatic characteristics, such as high affinity and specificity to the corresponding substrate, enable effective therapies, with minimal adverse effects and complete remission. However, immunogenicity, short half-life, low enzymatic yield, and low selectivity regarding available enzyme drugs are currently the main obstacles to their development and the broad adherence to therapeutic protocols. By harboring adapted and still unexplored microbial life, environments of extreme conditions, such as Antarctica, become especially important in the prospecting and development of new enzymatic compounds that present higher yields and the possibility of genetic improvement. Antarctic microorganisms have adaptation mechanisms, such as more fluid cell membranes, production of antifreeze proteins and enzymes with more malleable structures, more robust, stable, selective catalytic sites for their respective substrates, and high antioxidant capacity. In this context, this review aims to explore enzymes synthesized by bacteria and fungi from Antarctica as potential drug producers, capable of providing therapeutic efficacy, less adverse effects, and lower production costs with highlight to L-Asparaginase, collagenase, superoxide dismutase and ribonucleases. In addition, this review highlights the unique biotechnological profile of these Antarctic extremophile microorganisms. |
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Antarctic environments as a source of bacterial and fungal therapeutic enzymesAntarcticaCollagenaseExtremophilesL-AsparaginaseSuperoxide dismutaseTherapeutics enzymesMicrobial therapeutic enzymes are the protagonists in the pharmacological treatment of different human diseases. The intrinsic enzymatic characteristics, such as high affinity and specificity to the corresponding substrate, enable effective therapies, with minimal adverse effects and complete remission. However, immunogenicity, short half-life, low enzymatic yield, and low selectivity regarding available enzyme drugs are currently the main obstacles to their development and the broad adherence to therapeutic protocols. By harboring adapted and still unexplored microbial life, environments of extreme conditions, such as Antarctica, become especially important in the prospecting and development of new enzymatic compounds that present higher yields and the possibility of genetic improvement. Antarctic microorganisms have adaptation mechanisms, such as more fluid cell membranes, production of antifreeze proteins and enzymes with more malleable structures, more robust, stable, selective catalytic sites for their respective substrates, and high antioxidant capacity. In this context, this review aims to explore enzymes synthesized by bacteria and fungi from Antarctica as potential drug producers, capable of providing therapeutic efficacy, less adverse effects, and lower production costs with highlight to L-Asparaginase, collagenase, superoxide dismutase and ribonucleases. In addition, this review highlights the unique biotechnological profile of these Antarctic extremophile microorganisms.Universidade Federal de Alagoas Complexo de Ciências Médicas e Enfermagem, Campus Arapiraca, Av. Manoel Severino Barbosa, s/n, Bom SucessoUniversidade Federal de Alagoas Instituto de Ciências Biológicas e da Saúde, Av. Lourival Melo Mota, s/n, Tabuleiro do MartinsUniversidade Federal da Integração Latino-Americana, Av. Silvio Américo Sasdelli, 1842, Itaipú AUniversidade Estadual de Campinas Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrárias, R. Alexandre Cazellato, 999, BetelDepartamento de Biologia Geral e Aplicada Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho, Av. 24 A, 1515, Bela VistaUniversidade Federal de Minas Gerais Instituto de Ciências Biológicas, Av. Presidente Antônio Carlos, 6627, PampulhaDepartamento de Biologia Geral e Aplicada Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho, Av. 24 A, 1515, Bela VistaComplexo de Ciências Médicas e EnfermagemInstituto de Ciências Biológicas e da SaúdeUniversidade Federal da Integração Latino-AmericanaUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Universidade Federal de Minas Gerais (UFMG)Lima, Igor G. O.Bispo, James R. S.Agostinho, Adson Y. H.De Queiroz, Aline C.Moreira, Magna Suzana A.Passarini, Michel Rodrigo Z.De Oliveira, Valéria M.Sette, Lara D. [UNESP]Rosa, Luiz HenriqueDuarte, Alysson Wagner F.2022-04-28T19:50:50Z2022-04-28T19:50:50Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/0001-3765202220210452Anais da Academia Brasileira de Ciencias, v. 94.1678-26900001-3765http://hdl.handle.net/11449/22347110.1590/0001-37652022202104522-s2.0-85124679950Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais da Academia Brasileira de Cienciasinfo:eu-repo/semantics/openAccess2022-04-28T19:50:50Zoai:repositorio.unesp.br:11449/223471Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:26:09.894588Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antarctic environments as a source of bacterial and fungal therapeutic enzymes |
title |
Antarctic environments as a source of bacterial and fungal therapeutic enzymes |
spellingShingle |
Antarctic environments as a source of bacterial and fungal therapeutic enzymes Lima, Igor G. O. Antarctica Collagenase Extremophiles L-Asparaginase Superoxide dismutase Therapeutics enzymes |
title_short |
Antarctic environments as a source of bacterial and fungal therapeutic enzymes |
title_full |
Antarctic environments as a source of bacterial and fungal therapeutic enzymes |
title_fullStr |
Antarctic environments as a source of bacterial and fungal therapeutic enzymes |
title_full_unstemmed |
Antarctic environments as a source of bacterial and fungal therapeutic enzymes |
title_sort |
Antarctic environments as a source of bacterial and fungal therapeutic enzymes |
author |
Lima, Igor G. O. |
author_facet |
Lima, Igor G. O. Bispo, James R. S. Agostinho, Adson Y. H. De Queiroz, Aline C. Moreira, Magna Suzana A. Passarini, Michel Rodrigo Z. De Oliveira, Valéria M. Sette, Lara D. [UNESP] Rosa, Luiz Henrique Duarte, Alysson Wagner F. |
author_role |
author |
author2 |
Bispo, James R. S. Agostinho, Adson Y. H. De Queiroz, Aline C. Moreira, Magna Suzana A. Passarini, Michel Rodrigo Z. De Oliveira, Valéria M. Sette, Lara D. [UNESP] Rosa, Luiz Henrique Duarte, Alysson Wagner F. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Complexo de Ciências Médicas e Enfermagem Instituto de Ciências Biológicas e da Saúde Universidade Federal da Integração Latino-Americana Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (UNESP) Universidade Federal de Minas Gerais (UFMG) |
dc.contributor.author.fl_str_mv |
Lima, Igor G. O. Bispo, James R. S. Agostinho, Adson Y. H. De Queiroz, Aline C. Moreira, Magna Suzana A. Passarini, Michel Rodrigo Z. De Oliveira, Valéria M. Sette, Lara D. [UNESP] Rosa, Luiz Henrique Duarte, Alysson Wagner F. |
dc.subject.por.fl_str_mv |
Antarctica Collagenase Extremophiles L-Asparaginase Superoxide dismutase Therapeutics enzymes |
topic |
Antarctica Collagenase Extremophiles L-Asparaginase Superoxide dismutase Therapeutics enzymes |
description |
Microbial therapeutic enzymes are the protagonists in the pharmacological treatment of different human diseases. The intrinsic enzymatic characteristics, such as high affinity and specificity to the corresponding substrate, enable effective therapies, with minimal adverse effects and complete remission. However, immunogenicity, short half-life, low enzymatic yield, and low selectivity regarding available enzyme drugs are currently the main obstacles to their development and the broad adherence to therapeutic protocols. By harboring adapted and still unexplored microbial life, environments of extreme conditions, such as Antarctica, become especially important in the prospecting and development of new enzymatic compounds that present higher yields and the possibility of genetic improvement. Antarctic microorganisms have adaptation mechanisms, such as more fluid cell membranes, production of antifreeze proteins and enzymes with more malleable structures, more robust, stable, selective catalytic sites for their respective substrates, and high antioxidant capacity. In this context, this review aims to explore enzymes synthesized by bacteria and fungi from Antarctica as potential drug producers, capable of providing therapeutic efficacy, less adverse effects, and lower production costs with highlight to L-Asparaginase, collagenase, superoxide dismutase and ribonucleases. In addition, this review highlights the unique biotechnological profile of these Antarctic extremophile microorganisms. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-28T19:50:50Z 2022-04-28T19:50:50Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0001-3765202220210452 Anais da Academia Brasileira de Ciencias, v. 94. 1678-2690 0001-3765 http://hdl.handle.net/11449/223471 10.1590/0001-3765202220210452 2-s2.0-85124679950 |
url |
http://dx.doi.org/10.1590/0001-3765202220210452 http://hdl.handle.net/11449/223471 |
identifier_str_mv |
Anais da Academia Brasileira de Ciencias, v. 94. 1678-2690 0001-3765 10.1590/0001-3765202220210452 2-s2.0-85124679950 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais da Academia Brasileira de Ciencias |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129320254701568 |