Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/ar.21314 http://hdl.handle.net/11449/6474 |
Resumo: | In the past decades, the therapeutic use of anabolic androgenic steroids (AAS) has been overshadowed by illicit abuse of these drugs by athletes and non-athletes. Since that AAS can affect the reproductive tract, resulting in reproduction and fertilization damages, the purpose of this study was to investigate the nandrolone decanoate (ND) effects, associated or not with physical effort, on the uterine histomorphometric parameters. Female Wistar rats, sedentary or not, were exposed to treatment with ND by intraperitoneal injection (5 mg/kg/day, once a week) during four consecutive weeks. Control animals, sedentary or not, received vehicle alone (propylene glycol) in the same manner. The physical activity was forced swimming (20 min/day). During the experiment, all animals were monitored by daily vaginal smears. After 30 days of treatment, the females were sacrificed and their uteri collected and examined under light microscopy techniques. The ND-treated females showed estrus acyclicity and decreased thickness of both the epithelium and endometrial stroma. A reduction in the number and size of blood vessels was also found in ND-treated rats submitted to physical effort when compared to ND sedentary rats. ND-treated rats, regardless of exercise, exhibited stromal fibrosis and reduced gland ducts that displayed high mitotic activity. A remarkable widespread presence of leukocytes occurred in rats receiving ND and submitted to exercise. These results suggest that ND associated or not with physical effort causes histomorphometric changes to the rat uterus. Anat Rec, 294:335-341, 2011. (C) 2010 Wiley-Liss, Inc. |
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Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterusnandrolone decanoatesteroidsuterushistologyexerciseratIn the past decades, the therapeutic use of anabolic androgenic steroids (AAS) has been overshadowed by illicit abuse of these drugs by athletes and non-athletes. Since that AAS can affect the reproductive tract, resulting in reproduction and fertilization damages, the purpose of this study was to investigate the nandrolone decanoate (ND) effects, associated or not with physical effort, on the uterine histomorphometric parameters. Female Wistar rats, sedentary or not, were exposed to treatment with ND by intraperitoneal injection (5 mg/kg/day, once a week) during four consecutive weeks. Control animals, sedentary or not, received vehicle alone (propylene glycol) in the same manner. The physical activity was forced swimming (20 min/day). During the experiment, all animals were monitored by daily vaginal smears. After 30 days of treatment, the females were sacrificed and their uteri collected and examined under light microscopy techniques. The ND-treated females showed estrus acyclicity and decreased thickness of both the epithelium and endometrial stroma. A reduction in the number and size of blood vessels was also found in ND-treated rats submitted to physical effort when compared to ND sedentary rats. ND-treated rats, regardless of exercise, exhibited stromal fibrosis and reduced gland ducts that displayed high mitotic activity. A remarkable widespread presence of leukocytes occurred in rats receiving ND and submitted to exercise. These results suggest that ND associated or not with physical effort causes histomorphometric changes to the rat uterus. Anat Rec, 294:335-341, 2011. (C) 2010 Wiley-Liss, Inc.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Paulista State Univ UNESP, Dept Biol Sci, Fac Sci & Letters, Assis, SP, BrazilPaulista State Univ UNESP, Dept Expt Psychol, Fac Sci & Letters, Assis, SP, BrazilState Univ Londrina UEL, Dept Gen Biol, Londrina, Parana, BrazilPaulista State Univ UNESP, Dept Biol Sci, Fac Sci & Letters, Assis, SP, BrazilPaulista State Univ UNESP, Dept Expt Psychol, Fac Sci & Letters, Assis, SP, BrazilWiley-lissUniversidade Estadual Paulista (Unesp)Universidade Estadual de Londrina (UEL)de Almeida Chuffa, Luiz Gustavo [UNESP]de Souza, Roberta Barreiros [UNESP]Frei, Fernando [UNESP]Paccola Mesquita, Suzana de FatimaCamargo, Isabel Cristina Cherici [UNESP]2014-05-20T13:22:10Z2014-05-20T13:22:10Z2011-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article335-341http://dx.doi.org/10.1002/ar.21314Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Hoboken: Wiley-liss, v. 294, n. 2, p. 335-341, 2011.1932-8486http://hdl.handle.net/11449/647410.1002/ar.21314WOS:0002864418000174165274708509804Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology1.3730,766info:eu-repo/semantics/openAccess2024-06-14T18:10:49Zoai:repositorio.unesp.br:11449/6474Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:47:19.238437Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus |
title |
Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus |
spellingShingle |
Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus de Almeida Chuffa, Luiz Gustavo [UNESP] nandrolone decanoate steroids uterus histology exercise rat |
title_short |
Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus |
title_full |
Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus |
title_fullStr |
Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus |
title_full_unstemmed |
Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus |
title_sort |
Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus |
author |
de Almeida Chuffa, Luiz Gustavo [UNESP] |
author_facet |
de Almeida Chuffa, Luiz Gustavo [UNESP] de Souza, Roberta Barreiros [UNESP] Frei, Fernando [UNESP] Paccola Mesquita, Suzana de Fatima Camargo, Isabel Cristina Cherici [UNESP] |
author_role |
author |
author2 |
de Souza, Roberta Barreiros [UNESP] Frei, Fernando [UNESP] Paccola Mesquita, Suzana de Fatima Camargo, Isabel Cristina Cherici [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Londrina (UEL) |
dc.contributor.author.fl_str_mv |
de Almeida Chuffa, Luiz Gustavo [UNESP] de Souza, Roberta Barreiros [UNESP] Frei, Fernando [UNESP] Paccola Mesquita, Suzana de Fatima Camargo, Isabel Cristina Cherici [UNESP] |
dc.subject.por.fl_str_mv |
nandrolone decanoate steroids uterus histology exercise rat |
topic |
nandrolone decanoate steroids uterus histology exercise rat |
description |
In the past decades, the therapeutic use of anabolic androgenic steroids (AAS) has been overshadowed by illicit abuse of these drugs by athletes and non-athletes. Since that AAS can affect the reproductive tract, resulting in reproduction and fertilization damages, the purpose of this study was to investigate the nandrolone decanoate (ND) effects, associated or not with physical effort, on the uterine histomorphometric parameters. Female Wistar rats, sedentary or not, were exposed to treatment with ND by intraperitoneal injection (5 mg/kg/day, once a week) during four consecutive weeks. Control animals, sedentary or not, received vehicle alone (propylene glycol) in the same manner. The physical activity was forced swimming (20 min/day). During the experiment, all animals were monitored by daily vaginal smears. After 30 days of treatment, the females were sacrificed and their uteri collected and examined under light microscopy techniques. The ND-treated females showed estrus acyclicity and decreased thickness of both the epithelium and endometrial stroma. A reduction in the number and size of blood vessels was also found in ND-treated rats submitted to physical effort when compared to ND sedentary rats. ND-treated rats, regardless of exercise, exhibited stromal fibrosis and reduced gland ducts that displayed high mitotic activity. A remarkable widespread presence of leukocytes occurred in rats receiving ND and submitted to exercise. These results suggest that ND associated or not with physical effort causes histomorphometric changes to the rat uterus. Anat Rec, 294:335-341, 2011. (C) 2010 Wiley-Liss, Inc. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-02-01 2014-05-20T13:22:10Z 2014-05-20T13:22:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/ar.21314 Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Hoboken: Wiley-liss, v. 294, n. 2, p. 335-341, 2011. 1932-8486 http://hdl.handle.net/11449/6474 10.1002/ar.21314 WOS:000286441800017 4165274708509804 |
url |
http://dx.doi.org/10.1002/ar.21314 http://hdl.handle.net/11449/6474 |
identifier_str_mv |
Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Hoboken: Wiley-liss, v. 294, n. 2, p. 335-341, 2011. 1932-8486 10.1002/ar.21314 WOS:000286441800017 4165274708509804 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology 1.373 0,766 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
335-341 |
dc.publisher.none.fl_str_mv |
Wiley-liss |
publisher.none.fl_str_mv |
Wiley-liss |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129551901917184 |