Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus

Detalhes bibliográficos
Autor(a) principal: Bassetto, C. C. [UNESP]
Data de Publicação: 2011
Outros Autores: Silva, B. F. [UNESP], Newlands, G. F. J., Smith, W. D., Amarante, Alessandro Francisco Talamini do [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1111/j.1365-3024.2011.01295.x
http://hdl.handle.net/11449/18918
Resumo: A vaccine containing integral membrane glycoproteins from the intestine of Haemonchus contortus was evaluated in four groups of nine worm-free calves challenged with either 8000 H. contortus or Haemonchus placei infective larvae. Vaccinates received 50 mu g of the antigen and 1 mg QuilA adjuvant three times 21 days apart, while the controls got adjuvant alone. The calves were challenged 7 days after the last immunization and killed for worm counts 43 days later. Immunization resulted in high titre antibodies against the vaccine antigens and significant reduction in egg output and worm numbers of both challenge species, compared with control calves. It was concluded that vaccination of calves with native parasite gut membrane glycoproteins obtained from H. contortus conferred protection against both H. placei and H. contortus.
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spelling Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortuscattleHaemonchus contortusHaemonchus placeiparasitic gastroenteritisvaccineA vaccine containing integral membrane glycoproteins from the intestine of Haemonchus contortus was evaluated in four groups of nine worm-free calves challenged with either 8000 H. contortus or Haemonchus placei infective larvae. Vaccinates received 50 mu g of the antigen and 1 mg QuilA adjuvant three times 21 days apart, while the controls got adjuvant alone. The calves were challenged 7 days after the last immunization and killed for worm counts 43 days later. Immunization resulted in high titre antibodies against the vaccine antigens and significant reduction in egg output and worm numbers of both challenge species, compared with control calves. It was concluded that vaccination of calves with native parasite gut membrane glycoproteins obtained from H. contortus conferred protection against both H. placei and H. contortus.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista UNESP, Dept Parasitol, Inst Biociencias, BR-18618000 Botucatu, SP, BrazilMoredun Res Inst, Edinburgh EH17 7JH, Midlothian, ScotlandUniv Estadual Paulista UNESP, Dept Parasitol, Inst Biociencias, BR-18618000 Botucatu, SP, BrazilWiley-BlackwellUniversidade Estadual Paulista (Unesp)Moredun Res InstBassetto, C. C. [UNESP]Silva, B. F. [UNESP]Newlands, G. F. J.Smith, W. D.Amarante, Alessandro Francisco Talamini do [UNESP]2014-05-20T13:53:02Z2014-05-20T13:53:02Z2011-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article377-381http://dx.doi.org/10.1111/j.1365-3024.2011.01295.xParasite Immunology. Malden: Wiley-blackwell, v. 33, n. 7, p. 377-381, 2011.0141-9838http://hdl.handle.net/11449/1891810.1111/j.1365-3024.2011.01295.xWOS:0002927601000032677231663329706Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengParasite Immunology2.8361,173info:eu-repo/semantics/openAccess2021-10-23T15:24:59Zoai:repositorio.unesp.br:11449/18918Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:34:01.569366Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus
title Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus
spellingShingle Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus
Bassetto, C. C. [UNESP]
cattle
Haemonchus contortus
Haemonchus placei
parasitic gastroenteritis
vaccine
title_short Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus
title_full Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus
title_fullStr Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus
title_full_unstemmed Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus
title_sort Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus
author Bassetto, C. C. [UNESP]
author_facet Bassetto, C. C. [UNESP]
Silva, B. F. [UNESP]
Newlands, G. F. J.
Smith, W. D.
Amarante, Alessandro Francisco Talamini do [UNESP]
author_role author
author2 Silva, B. F. [UNESP]
Newlands, G. F. J.
Smith, W. D.
Amarante, Alessandro Francisco Talamini do [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Moredun Res Inst
dc.contributor.author.fl_str_mv Bassetto, C. C. [UNESP]
Silva, B. F. [UNESP]
Newlands, G. F. J.
Smith, W. D.
Amarante, Alessandro Francisco Talamini do [UNESP]
dc.subject.por.fl_str_mv cattle
Haemonchus contortus
Haemonchus placei
parasitic gastroenteritis
vaccine
topic cattle
Haemonchus contortus
Haemonchus placei
parasitic gastroenteritis
vaccine
description A vaccine containing integral membrane glycoproteins from the intestine of Haemonchus contortus was evaluated in four groups of nine worm-free calves challenged with either 8000 H. contortus or Haemonchus placei infective larvae. Vaccinates received 50 mu g of the antigen and 1 mg QuilA adjuvant three times 21 days apart, while the controls got adjuvant alone. The calves were challenged 7 days after the last immunization and killed for worm counts 43 days later. Immunization resulted in high titre antibodies against the vaccine antigens and significant reduction in egg output and worm numbers of both challenge species, compared with control calves. It was concluded that vaccination of calves with native parasite gut membrane glycoproteins obtained from H. contortus conferred protection against both H. placei and H. contortus.
publishDate 2011
dc.date.none.fl_str_mv 2011-07-01
2014-05-20T13:53:02Z
2014-05-20T13:53:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/j.1365-3024.2011.01295.x
Parasite Immunology. Malden: Wiley-blackwell, v. 33, n. 7, p. 377-381, 2011.
0141-9838
http://hdl.handle.net/11449/18918
10.1111/j.1365-3024.2011.01295.x
WOS:000292760100003
2677231663329706
url http://dx.doi.org/10.1111/j.1365-3024.2011.01295.x
http://hdl.handle.net/11449/18918
identifier_str_mv Parasite Immunology. Malden: Wiley-blackwell, v. 33, n. 7, p. 377-381, 2011.
0141-9838
10.1111/j.1365-3024.2011.01295.x
WOS:000292760100003
2677231663329706
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Parasite Immunology
2.836
1,173
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 377-381
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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