Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/j.1365-3024.2011.01295.x http://hdl.handle.net/11449/18918 |
Resumo: | A vaccine containing integral membrane glycoproteins from the intestine of Haemonchus contortus was evaluated in four groups of nine worm-free calves challenged with either 8000 H. contortus or Haemonchus placei infective larvae. Vaccinates received 50 mu g of the antigen and 1 mg QuilA adjuvant three times 21 days apart, while the controls got adjuvant alone. The calves were challenged 7 days after the last immunization and killed for worm counts 43 days later. Immunization resulted in high titre antibodies against the vaccine antigens and significant reduction in egg output and worm numbers of both challenge species, compared with control calves. It was concluded that vaccination of calves with native parasite gut membrane glycoproteins obtained from H. contortus conferred protection against both H. placei and H. contortus. |
id |
UNSP_4f59f092526e957bc28c546c3a5b9678 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/18918 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortuscattleHaemonchus contortusHaemonchus placeiparasitic gastroenteritisvaccineA vaccine containing integral membrane glycoproteins from the intestine of Haemonchus contortus was evaluated in four groups of nine worm-free calves challenged with either 8000 H. contortus or Haemonchus placei infective larvae. Vaccinates received 50 mu g of the antigen and 1 mg QuilA adjuvant three times 21 days apart, while the controls got adjuvant alone. The calves were challenged 7 days after the last immunization and killed for worm counts 43 days later. Immunization resulted in high titre antibodies against the vaccine antigens and significant reduction in egg output and worm numbers of both challenge species, compared with control calves. It was concluded that vaccination of calves with native parasite gut membrane glycoproteins obtained from H. contortus conferred protection against both H. placei and H. contortus.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista UNESP, Dept Parasitol, Inst Biociencias, BR-18618000 Botucatu, SP, BrazilMoredun Res Inst, Edinburgh EH17 7JH, Midlothian, ScotlandUniv Estadual Paulista UNESP, Dept Parasitol, Inst Biociencias, BR-18618000 Botucatu, SP, BrazilWiley-BlackwellUniversidade Estadual Paulista (Unesp)Moredun Res InstBassetto, C. C. [UNESP]Silva, B. F. [UNESP]Newlands, G. F. J.Smith, W. D.Amarante, Alessandro Francisco Talamini do [UNESP]2014-05-20T13:53:02Z2014-05-20T13:53:02Z2011-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article377-381http://dx.doi.org/10.1111/j.1365-3024.2011.01295.xParasite Immunology. Malden: Wiley-blackwell, v. 33, n. 7, p. 377-381, 2011.0141-9838http://hdl.handle.net/11449/1891810.1111/j.1365-3024.2011.01295.xWOS:0002927601000032677231663329706Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengParasite Immunology2.8361,173info:eu-repo/semantics/openAccess2021-10-23T15:24:59Zoai:repositorio.unesp.br:11449/18918Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:34:01.569366Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus |
title |
Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus |
spellingShingle |
Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus Bassetto, C. C. [UNESP] cattle Haemonchus contortus Haemonchus placei parasitic gastroenteritis vaccine |
title_short |
Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus |
title_full |
Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus |
title_fullStr |
Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus |
title_full_unstemmed |
Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus |
title_sort |
Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus |
author |
Bassetto, C. C. [UNESP] |
author_facet |
Bassetto, C. C. [UNESP] Silva, B. F. [UNESP] Newlands, G. F. J. Smith, W. D. Amarante, Alessandro Francisco Talamini do [UNESP] |
author_role |
author |
author2 |
Silva, B. F. [UNESP] Newlands, G. F. J. Smith, W. D. Amarante, Alessandro Francisco Talamini do [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Moredun Res Inst |
dc.contributor.author.fl_str_mv |
Bassetto, C. C. [UNESP] Silva, B. F. [UNESP] Newlands, G. F. J. Smith, W. D. Amarante, Alessandro Francisco Talamini do [UNESP] |
dc.subject.por.fl_str_mv |
cattle Haemonchus contortus Haemonchus placei parasitic gastroenteritis vaccine |
topic |
cattle Haemonchus contortus Haemonchus placei parasitic gastroenteritis vaccine |
description |
A vaccine containing integral membrane glycoproteins from the intestine of Haemonchus contortus was evaluated in four groups of nine worm-free calves challenged with either 8000 H. contortus or Haemonchus placei infective larvae. Vaccinates received 50 mu g of the antigen and 1 mg QuilA adjuvant three times 21 days apart, while the controls got adjuvant alone. The calves were challenged 7 days after the last immunization and killed for worm counts 43 days later. Immunization resulted in high titre antibodies against the vaccine antigens and significant reduction in egg output and worm numbers of both challenge species, compared with control calves. It was concluded that vaccination of calves with native parasite gut membrane glycoproteins obtained from H. contortus conferred protection against both H. placei and H. contortus. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-07-01 2014-05-20T13:53:02Z 2014-05-20T13:53:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/j.1365-3024.2011.01295.x Parasite Immunology. Malden: Wiley-blackwell, v. 33, n. 7, p. 377-381, 2011. 0141-9838 http://hdl.handle.net/11449/18918 10.1111/j.1365-3024.2011.01295.x WOS:000292760100003 2677231663329706 |
url |
http://dx.doi.org/10.1111/j.1365-3024.2011.01295.x http://hdl.handle.net/11449/18918 |
identifier_str_mv |
Parasite Immunology. Malden: Wiley-blackwell, v. 33, n. 7, p. 377-381, 2011. 0141-9838 10.1111/j.1365-3024.2011.01295.x WOS:000292760100003 2677231663329706 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Parasite Immunology 2.836 1,173 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
377-381 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129086351998976 |