Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1100/2012/780890 http://hdl.handle.net/11449/73389 |
Resumo: | Aims. To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals. Main Methods. Male Wistar rats were randomly divided into two groups: control (C)fed with commercial chow ad libitumand obese (OB)fed with a hypercaloric diet. After group characterization, the OB rats continued receiving a hypercaloric diet and were randomized into two groups: obese animals (OB) and obese with 25g triiodothyronine (T3)/100BW (OT). The T3 dose was administered every day for the last 2 weeks of the study. After 30 weeks the animals were euthanized. Samples of blood and adipose tissue were collected for biochemical and hormonal analyses as well as gene expression of leptin, resistin, and adiponectin. Results. T3 treatment was effective, increasing fT3 levels and decreasing fT4 and TSH serum concentration. Administration of T3 promotes weight loss, decreases all fat deposits, and diminishes serum levels of leptin, resistin, and adiponectin by reducing their gene expression. Conclusions. Our results suggest that T3 modulate serum and gene expression levels of leptin, resistin, and adiponectin in experimental model of obesity, providing new insights regarding the relationship between T3 and adipokines in obesity. Copyright © 2012 Renata de Azevedo Melo Luvizotto et al. |
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Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesityadipocytokineadiponectinfatty acidglucoseleptinliothyronineresistinthyrotropinthyroxinetriacylglyceroladipose tissueanimal euthanasiaanimal experimentanimal tissuebiochemistryblood samplingbody fatcontrolled studydietexperimental hyperthyroidismfree liothyronine indexfree thyroxine indexgene expressionhormone determinationhypercaloric diethyperthyroidismmalenonhumanobesityratweight reductionanimalbiosynthesisbloodbody weightdisease modelgene expression regulationhomeostasismetabolismrandomizationWistar ratAdiponectinAdipose TissueAnimalsBody WeightDisease Models, AnimalGene Expression RegulationHomeostasisHyperthyroidismLeptinMaleObesityRandom AllocationRatsRats, WistarResistinThyrotropinThyroxineTriiodothyronineAims. To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals. Main Methods. Male Wistar rats were randomly divided into two groups: control (C)fed with commercial chow ad libitumand obese (OB)fed with a hypercaloric diet. After group characterization, the OB rats continued receiving a hypercaloric diet and were randomized into two groups: obese animals (OB) and obese with 25g triiodothyronine (T3)/100BW (OT). The T3 dose was administered every day for the last 2 weeks of the study. After 30 weeks the animals were euthanized. Samples of blood and adipose tissue were collected for biochemical and hormonal analyses as well as gene expression of leptin, resistin, and adiponectin. Results. T3 treatment was effective, increasing fT3 levels and decreasing fT4 and TSH serum concentration. Administration of T3 promotes weight loss, decreases all fat deposits, and diminishes serum levels of leptin, resistin, and adiponectin by reducing their gene expression. Conclusions. Our results suggest that T3 modulate serum and gene expression levels of leptin, resistin, and adiponectin in experimental model of obesity, providing new insights regarding the relationship between T3 and adipokines in obesity. Copyright © 2012 Renata de Azevedo Melo Luvizotto et al.Department of Internal Medicine Botucatu School of Medicine University of São Paulo State, 18618-000 Botucatu, SPDepartment of Sports Center of Physical Education and Sports Federal University of Espirito Santo (UFES), 29075-910 Vitória, ESUniversidade Estadual Paulista (Unesp)Universidade Federal do Espírito Santo (UFES)Luvizotto, Renata de Azevedo MeloNascimento, André Ferreira DoSíbio, Maria Teresa DeOlímpio, Regiane Marques CastroConde, Sandro JoséLima-Leopoldo, Ana PaulaLeopoldo, André SoaresCicogna, Antonio Carlos [UNESP]Nogueira, Célia Regina [UNESP]2014-05-27T11:26:51Z2014-05-27T11:26:51Z2012-06-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1100/2012/780890The Scientific World Journal, v. 2012.1537-744Xhttp://hdl.handle.net/11449/7338910.1100/2012/7808902-s2.0-848623339292-s2.0-84862333929.pdf9418970103564137Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengThe Scientific World Journalinfo:eu-repo/semantics/openAccess2024-08-14T17:23:43Zoai:repositorio.unesp.br:11449/73389Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity |
title |
Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity |
spellingShingle |
Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity Luvizotto, Renata de Azevedo Melo adipocytokine adiponectin fatty acid glucose leptin liothyronine resistin thyrotropin thyroxine triacylglycerol adipose tissue animal euthanasia animal experiment animal tissue biochemistry blood sampling body fat controlled study diet experimental hyperthyroidism free liothyronine index free thyroxine index gene expression hormone determination hypercaloric diet hyperthyroidism male nonhuman obesity rat weight reduction animal biosynthesis blood body weight disease model gene expression regulation homeostasis metabolism randomization Wistar rat Adiponectin Adipose Tissue Animals Body Weight Disease Models, Animal Gene Expression Regulation Homeostasis Hyperthyroidism Leptin Male Obesity Random Allocation Rats Rats, Wistar Resistin Thyrotropin Thyroxine Triiodothyronine |
title_short |
Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity |
title_full |
Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity |
title_fullStr |
Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity |
title_full_unstemmed |
Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity |
title_sort |
Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity |
author |
Luvizotto, Renata de Azevedo Melo |
author_facet |
Luvizotto, Renata de Azevedo Melo Nascimento, André Ferreira Do Síbio, Maria Teresa De Olímpio, Regiane Marques Castro Conde, Sandro José Lima-Leopoldo, Ana Paula Leopoldo, André Soares Cicogna, Antonio Carlos [UNESP] Nogueira, Célia Regina [UNESP] |
author_role |
author |
author2 |
Nascimento, André Ferreira Do Síbio, Maria Teresa De Olímpio, Regiane Marques Castro Conde, Sandro José Lima-Leopoldo, Ana Paula Leopoldo, André Soares Cicogna, Antonio Carlos [UNESP] Nogueira, Célia Regina [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal do Espírito Santo (UFES) |
dc.contributor.author.fl_str_mv |
Luvizotto, Renata de Azevedo Melo Nascimento, André Ferreira Do Síbio, Maria Teresa De Olímpio, Regiane Marques Castro Conde, Sandro José Lima-Leopoldo, Ana Paula Leopoldo, André Soares Cicogna, Antonio Carlos [UNESP] Nogueira, Célia Regina [UNESP] |
dc.subject.por.fl_str_mv |
adipocytokine adiponectin fatty acid glucose leptin liothyronine resistin thyrotropin thyroxine triacylglycerol adipose tissue animal euthanasia animal experiment animal tissue biochemistry blood sampling body fat controlled study diet experimental hyperthyroidism free liothyronine index free thyroxine index gene expression hormone determination hypercaloric diet hyperthyroidism male nonhuman obesity rat weight reduction animal biosynthesis blood body weight disease model gene expression regulation homeostasis metabolism randomization Wistar rat Adiponectin Adipose Tissue Animals Body Weight Disease Models, Animal Gene Expression Regulation Homeostasis Hyperthyroidism Leptin Male Obesity Random Allocation Rats Rats, Wistar Resistin Thyrotropin Thyroxine Triiodothyronine |
topic |
adipocytokine adiponectin fatty acid glucose leptin liothyronine resistin thyrotropin thyroxine triacylglycerol adipose tissue animal euthanasia animal experiment animal tissue biochemistry blood sampling body fat controlled study diet experimental hyperthyroidism free liothyronine index free thyroxine index gene expression hormone determination hypercaloric diet hyperthyroidism male nonhuman obesity rat weight reduction animal biosynthesis blood body weight disease model gene expression regulation homeostasis metabolism randomization Wistar rat Adiponectin Adipose Tissue Animals Body Weight Disease Models, Animal Gene Expression Regulation Homeostasis Hyperthyroidism Leptin Male Obesity Random Allocation Rats Rats, Wistar Resistin Thyrotropin Thyroxine Triiodothyronine |
description |
Aims. To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals. Main Methods. Male Wistar rats were randomly divided into two groups: control (C)fed with commercial chow ad libitumand obese (OB)fed with a hypercaloric diet. After group characterization, the OB rats continued receiving a hypercaloric diet and were randomized into two groups: obese animals (OB) and obese with 25g triiodothyronine (T3)/100BW (OT). The T3 dose was administered every day for the last 2 weeks of the study. After 30 weeks the animals were euthanized. Samples of blood and adipose tissue were collected for biochemical and hormonal analyses as well as gene expression of leptin, resistin, and adiponectin. Results. T3 treatment was effective, increasing fT3 levels and decreasing fT4 and TSH serum concentration. Administration of T3 promotes weight loss, decreases all fat deposits, and diminishes serum levels of leptin, resistin, and adiponectin by reducing their gene expression. Conclusions. Our results suggest that T3 modulate serum and gene expression levels of leptin, resistin, and adiponectin in experimental model of obesity, providing new insights regarding the relationship between T3 and adipokines in obesity. Copyright © 2012 Renata de Azevedo Melo Luvizotto et al. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-21 2014-05-27T11:26:51Z 2014-05-27T11:26:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1100/2012/780890 The Scientific World Journal, v. 2012. 1537-744X http://hdl.handle.net/11449/73389 10.1100/2012/780890 2-s2.0-84862333929 2-s2.0-84862333929.pdf 9418970103564137 |
url |
http://dx.doi.org/10.1100/2012/780890 http://hdl.handle.net/11449/73389 |
identifier_str_mv |
The Scientific World Journal, v. 2012. 1537-744X 10.1100/2012/780890 2-s2.0-84862333929 2-s2.0-84862333929.pdf 9418970103564137 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
The Scientific World Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128176142942208 |