Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia

Detalhes bibliográficos
Autor(a) principal: Santos, Glenda Dias
Data de Publicação: 2015
Outros Autores: Nunes, Paula Villela, Stella, Florindo [UNESP], Brum, Paula Schimidt, Yassuda, Monica Sanches [UNESP], Ueno, Linda Massako, Gattaz, Wagner Farid, Forlenza, Orestes Vicente
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/0101-60830000000066
http://hdl.handle.net/11449/176890
Resumo: Background: Non-pharmalogical interventions represent an important complement to standard pharmalogical treatment in dementia. Objective: This study aims to evaluate the effects of a multidisciplinary rehabilitation program on cognitive ability, quality of life and depression symptoms in patients with Alzheimer’s disease (AD) and cognitive impairment without dementia (CIND). Methods: Ninety-seven older adults were recruited to the present study. Of these, 70 patients had mild AD and were allocated into experimental (n = 54) or control (n = 16) groups. Two additional active comparison groups were constituted with patients with moderate AD (n = 13) or with CIND (n = 14) who also received the intervention. The multidisciplinary rehabilitation program lasted for 12 weeks and was composed by sessions of memory training, recreational activities, verbal expression and writing, physical therapy and physical training, delivered in two weekly 6-hour sessions. Results: As compared to controls, mild AD patients who received the intervention had improvements in cognition (p = 0.021) and quality of life (p = 0.003), along with a reduction in depressive symptoms (p < 0.001). As compared to baseline, CIND patients displayed at the end of the intervention improvements in cognition (p = 0.005) and depressive symptoms (p = 0.011). No such benefits were found among patients with moderate AD. Discussion: This multidisciplinary rehabilitation program was beneficial for patients with mild AD and CIND. However, patients with moderate dementia did not benefit from the intervention.
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spelling Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementiaAlzheimer diseaseImpairment cognitive without dementiaMultidisciplinary rehabilitation programMultimodal interventionBackground: Non-pharmalogical interventions represent an important complement to standard pharmalogical treatment in dementia. Objective: This study aims to evaluate the effects of a multidisciplinary rehabilitation program on cognitive ability, quality of life and depression symptoms in patients with Alzheimer’s disease (AD) and cognitive impairment without dementia (CIND). Methods: Ninety-seven older adults were recruited to the present study. Of these, 70 patients had mild AD and were allocated into experimental (n = 54) or control (n = 16) groups. Two additional active comparison groups were constituted with patients with moderate AD (n = 13) or with CIND (n = 14) who also received the intervention. The multidisciplinary rehabilitation program lasted for 12 weeks and was composed by sessions of memory training, recreational activities, verbal expression and writing, physical therapy and physical training, delivered in two weekly 6-hour sessions. Results: As compared to controls, mild AD patients who received the intervention had improvements in cognition (p = 0.021) and quality of life (p = 0.003), along with a reduction in depressive symptoms (p < 0.001). As compared to baseline, CIND patients displayed at the end of the intervention improvements in cognition (p = 0.005) and depressive symptoms (p = 0.011). No such benefits were found among patients with moderate AD. Discussion: This multidisciplinary rehabilitation program was beneficial for patients with mild AD and CIND. However, patients with moderate dementia did not benefit from the intervention.Laboratory of Neuroscience (LIM-27) Department and Institute of Psychiatry University of São PauloUniversidade Estadual Paulista (Unesp) Biosciences InstituteDepartment of Neurology University of São PauloSchool of Arts Sciences and Humanities University of São PauloUniversidade Estadual Paulista (Unesp) Biosciences InstituteUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Santos, Glenda DiasNunes, Paula VillelaStella, Florindo [UNESP]Brum, Paula SchimidtYassuda, Monica Sanches [UNESP]Ueno, Linda MassakoGattaz, Wagner FaridForlenza, Orestes Vicente2018-12-11T17:22:57Z2018-12-11T17:22:57Z2015-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article153-156application/pdfhttp://dx.doi.org/10.1590/0101-60830000000066Revista de Psiquiatria Clinica, v. 42, n. 6, p. 153-156, 2015.1806-938X0101-6083http://hdl.handle.net/11449/17689010.1590/0101-60830000000066S0101-608320150006001532-s2.0-84949795585S0101-60832015000600153.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista de Psiquiatria Clinica0,271info:eu-repo/semantics/openAccess2024-08-16T15:45:40Zoai:repositorio.unesp.br:11449/176890Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T15:45:40Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia
title Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia
spellingShingle Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia
Santos, Glenda Dias
Alzheimer disease
Impairment cognitive without dementia
Multidisciplinary rehabilitation program
Multimodal intervention
title_short Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia
title_full Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia
title_fullStr Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia
title_full_unstemmed Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia
title_sort Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia
author Santos, Glenda Dias
author_facet Santos, Glenda Dias
Nunes, Paula Villela
Stella, Florindo [UNESP]
Brum, Paula Schimidt
Yassuda, Monica Sanches [UNESP]
Ueno, Linda Massako
Gattaz, Wagner Farid
Forlenza, Orestes Vicente
author_role author
author2 Nunes, Paula Villela
Stella, Florindo [UNESP]
Brum, Paula Schimidt
Yassuda, Monica Sanches [UNESP]
Ueno, Linda Massako
Gattaz, Wagner Farid
Forlenza, Orestes Vicente
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Santos, Glenda Dias
Nunes, Paula Villela
Stella, Florindo [UNESP]
Brum, Paula Schimidt
Yassuda, Monica Sanches [UNESP]
Ueno, Linda Massako
Gattaz, Wagner Farid
Forlenza, Orestes Vicente
dc.subject.por.fl_str_mv Alzheimer disease
Impairment cognitive without dementia
Multidisciplinary rehabilitation program
Multimodal intervention
topic Alzheimer disease
Impairment cognitive without dementia
Multidisciplinary rehabilitation program
Multimodal intervention
description Background: Non-pharmalogical interventions represent an important complement to standard pharmalogical treatment in dementia. Objective: This study aims to evaluate the effects of a multidisciplinary rehabilitation program on cognitive ability, quality of life and depression symptoms in patients with Alzheimer’s disease (AD) and cognitive impairment without dementia (CIND). Methods: Ninety-seven older adults were recruited to the present study. Of these, 70 patients had mild AD and were allocated into experimental (n = 54) or control (n = 16) groups. Two additional active comparison groups were constituted with patients with moderate AD (n = 13) or with CIND (n = 14) who also received the intervention. The multidisciplinary rehabilitation program lasted for 12 weeks and was composed by sessions of memory training, recreational activities, verbal expression and writing, physical therapy and physical training, delivered in two weekly 6-hour sessions. Results: As compared to controls, mild AD patients who received the intervention had improvements in cognition (p = 0.021) and quality of life (p = 0.003), along with a reduction in depressive symptoms (p < 0.001). As compared to baseline, CIND patients displayed at the end of the intervention improvements in cognition (p = 0.005) and depressive symptoms (p = 0.011). No such benefits were found among patients with moderate AD. Discussion: This multidisciplinary rehabilitation program was beneficial for patients with mild AD and CIND. However, patients with moderate dementia did not benefit from the intervention.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-01
2018-12-11T17:22:57Z
2018-12-11T17:22:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/0101-60830000000066
Revista de Psiquiatria Clinica, v. 42, n. 6, p. 153-156, 2015.
1806-938X
0101-6083
http://hdl.handle.net/11449/176890
10.1590/0101-60830000000066
S0101-60832015000600153
2-s2.0-84949795585
S0101-60832015000600153.pdf
url http://dx.doi.org/10.1590/0101-60830000000066
http://hdl.handle.net/11449/176890
identifier_str_mv Revista de Psiquiatria Clinica, v. 42, n. 6, p. 153-156, 2015.
1806-938X
0101-6083
10.1590/0101-60830000000066
S0101-60832015000600153
2-s2.0-84949795585
S0101-60832015000600153.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista de Psiquiatria Clinica
0,271
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 153-156
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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