Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1159/000519003 http://hdl.handle.net/11449/233652 |
Resumo: | Cutaneous involvement is one of the most common extraintestinal manifestations of inflammatory bowel disease (IBD). More commonly, pyoderma gangrenosum and erythema nodosum are noted, but psoriasis, aphthous stomatitis, Sweet's syndrome, and vasculitis may also occur. Leukocytoclastic vasculitis (LCV) is a rare cutaneous manifestation, characterized by the appearance of palpable purpura, urticaria, and ulcer-necrotic lesions predominantly in the lower extremities that improve with immunosuppressive therapy. In this case, we report a patient with CD and LCV. We also searched the literature on the diagnosis and treatment of LCV in patients with CD. Female, 31, presented with diarrhea containing mucus and blood, abdominal pain, arthralgia, and enanthematous plaques and ulcers with a hematinic background in the lower extremities. The results of the colonoscopy were compatible with CD and skin biopsy showed signs of LCV. Systemic autoimmune disease and primary vasculitis were ruled out. The patient received treatment with a systemic corticosteroid and the skin lesions improved. Outpatient treatment with antitumor necrosis factor therapy was initiated to promote skin healing and IBD clinical remission. As LCV is a rare manifestation of IBD, it is necessary to distinguish this dermatopathy from other systemic vasculitis. The engagement of a multidisciplinary team is essential for the correct diagnosis and management. |
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Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's DiseaseCase reportCrohn's diseaseExtraintestinal manifestationInflammatory bowel diseaseLeukocytoclastic vasculitisCutaneous involvement is one of the most common extraintestinal manifestations of inflammatory bowel disease (IBD). More commonly, pyoderma gangrenosum and erythema nodosum are noted, but psoriasis, aphthous stomatitis, Sweet's syndrome, and vasculitis may also occur. Leukocytoclastic vasculitis (LCV) is a rare cutaneous manifestation, characterized by the appearance of palpable purpura, urticaria, and ulcer-necrotic lesions predominantly in the lower extremities that improve with immunosuppressive therapy. In this case, we report a patient with CD and LCV. We also searched the literature on the diagnosis and treatment of LCV in patients with CD. Female, 31, presented with diarrhea containing mucus and blood, abdominal pain, arthralgia, and enanthematous plaques and ulcers with a hematinic background in the lower extremities. The results of the colonoscopy were compatible with CD and skin biopsy showed signs of LCV. Systemic autoimmune disease and primary vasculitis were ruled out. The patient received treatment with a systemic corticosteroid and the skin lesions improved. Outpatient treatment with antitumor necrosis factor therapy was initiated to promote skin healing and IBD clinical remission. As LCV is a rare manifestation of IBD, it is necessary to distinguish this dermatopathy from other systemic vasculitis. The engagement of a multidisciplinary team is essential for the correct diagnosis and management.São Paulo State University (Unesp) Medical SchoolClinica Universidad de Los AndesSão Paulo State University (Unesp) Medical SchoolUniversidade Estadual Paulista (UNESP)Clinica Universidad de Los AndesRocha, Thiara Barcelos [UNESP]Garate, Ana Lorena Sousa De Vasconcelos [UNESP]Beraldo, Rodrigo Fedatto [UNESP]Lanças, Sean Hideo Shirata [UNESP]Leite, Fábio Vicente [UNESP]Quera, RodrigoBarros, Jaqueline Ribeiro [UNESP]Baima, Julio Pinheiro [UNESP]Saad-Hossne, Rogerio [UNESP]Sassaki, Ligia Yukie [UNESP]2022-05-01T09:31:07Z2022-05-01T09:31:07Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article825-831http://dx.doi.org/10.1159/000519003Case Reports in Gastroenterology, p. 825-831.1662-0631http://hdl.handle.net/11449/23365210.1159/0005190032-s2.0-85116828807Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCase Reports in Gastroenterologyinfo:eu-repo/semantics/openAccess2024-08-14T14:19:45Zoai:repositorio.unesp.br:11449/233652Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T14:19:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease |
title |
Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease |
spellingShingle |
Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease Rocha, Thiara Barcelos [UNESP] Case report Crohn's disease Extraintestinal manifestation Inflammatory bowel disease Leukocytoclastic vasculitis |
title_short |
Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease |
title_full |
Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease |
title_fullStr |
Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease |
title_full_unstemmed |
Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease |
title_sort |
Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease |
author |
Rocha, Thiara Barcelos [UNESP] |
author_facet |
Rocha, Thiara Barcelos [UNESP] Garate, Ana Lorena Sousa De Vasconcelos [UNESP] Beraldo, Rodrigo Fedatto [UNESP] Lanças, Sean Hideo Shirata [UNESP] Leite, Fábio Vicente [UNESP] Quera, Rodrigo Barros, Jaqueline Ribeiro [UNESP] Baima, Julio Pinheiro [UNESP] Saad-Hossne, Rogerio [UNESP] Sassaki, Ligia Yukie [UNESP] |
author_role |
author |
author2 |
Garate, Ana Lorena Sousa De Vasconcelos [UNESP] Beraldo, Rodrigo Fedatto [UNESP] Lanças, Sean Hideo Shirata [UNESP] Leite, Fábio Vicente [UNESP] Quera, Rodrigo Barros, Jaqueline Ribeiro [UNESP] Baima, Julio Pinheiro [UNESP] Saad-Hossne, Rogerio [UNESP] Sassaki, Ligia Yukie [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Clinica Universidad de Los Andes |
dc.contributor.author.fl_str_mv |
Rocha, Thiara Barcelos [UNESP] Garate, Ana Lorena Sousa De Vasconcelos [UNESP] Beraldo, Rodrigo Fedatto [UNESP] Lanças, Sean Hideo Shirata [UNESP] Leite, Fábio Vicente [UNESP] Quera, Rodrigo Barros, Jaqueline Ribeiro [UNESP] Baima, Julio Pinheiro [UNESP] Saad-Hossne, Rogerio [UNESP] Sassaki, Ligia Yukie [UNESP] |
dc.subject.por.fl_str_mv |
Case report Crohn's disease Extraintestinal manifestation Inflammatory bowel disease Leukocytoclastic vasculitis |
topic |
Case report Crohn's disease Extraintestinal manifestation Inflammatory bowel disease Leukocytoclastic vasculitis |
description |
Cutaneous involvement is one of the most common extraintestinal manifestations of inflammatory bowel disease (IBD). More commonly, pyoderma gangrenosum and erythema nodosum are noted, but psoriasis, aphthous stomatitis, Sweet's syndrome, and vasculitis may also occur. Leukocytoclastic vasculitis (LCV) is a rare cutaneous manifestation, characterized by the appearance of palpable purpura, urticaria, and ulcer-necrotic lesions predominantly in the lower extremities that improve with immunosuppressive therapy. In this case, we report a patient with CD and LCV. We also searched the literature on the diagnosis and treatment of LCV in patients with CD. Female, 31, presented with diarrhea containing mucus and blood, abdominal pain, arthralgia, and enanthematous plaques and ulcers with a hematinic background in the lower extremities. The results of the colonoscopy were compatible with CD and skin biopsy showed signs of LCV. Systemic autoimmune disease and primary vasculitis were ruled out. The patient received treatment with a systemic corticosteroid and the skin lesions improved. Outpatient treatment with antitumor necrosis factor therapy was initiated to promote skin healing and IBD clinical remission. As LCV is a rare manifestation of IBD, it is necessary to distinguish this dermatopathy from other systemic vasculitis. The engagement of a multidisciplinary team is essential for the correct diagnosis and management. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-05-01T09:31:07Z 2022-05-01T09:31:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1159/000519003 Case Reports in Gastroenterology, p. 825-831. 1662-0631 http://hdl.handle.net/11449/233652 10.1159/000519003 2-s2.0-85116828807 |
url |
http://dx.doi.org/10.1159/000519003 http://hdl.handle.net/11449/233652 |
identifier_str_mv |
Case Reports in Gastroenterology, p. 825-831. 1662-0631 10.1159/000519003 2-s2.0-85116828807 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Case Reports in Gastroenterology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
825-831 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128209321984000 |