Vagal tone regulates cardiac shunts during activity and at low temperatures in the South American rattlesnake, Crotalus durissus
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00360-016-1008-y http://hdl.handle.net/11449/168729 |
Resumo: | The undivided ventricle of non-crocodilian reptiles allows for intracardiac admixture of oxygen-poor and oxygen-rich blood returning via the atria from the systemic circuit and the lungs. The distribution of blood flow between the systemic and pulmonary circuits may vary, based on differences between systemic and pulmonary vascular conductances. The South American rattlesnake, Crotalus durissus, has a single pulmonary artery, innervated by the left vagus. Activity in this nerve controls pulmonary conductance so that left vagotomy abolishes this control. Experimental left vagotomy to abolish cardiac shunting had no effect on long-term survival and failed to identify a functional role in determining metabolic rate, growth or resistance to food deprivation. Accordingly, the present investigation sought to evaluate the extent to which cardiac shunt patterns are actively controlled during changes in body temperature and activity levels. We compared hemodynamic parameters between intact and left-vagotomized rattlesnakes held at different temperatures and subjected to enforced physical activity. Increased temperature and enforced activity raised heart rate, cardiac output, pulmonary and systemic blood flow in both groups, but net cardiac shunt was reversed in the vagotomized group at lower temperatures. We conclude that vagal control of pulmonary conductance is an active mechanism regulating cardiac shunts in C. durissus. |
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Vagal tone regulates cardiac shunts during activity and at low temperatures in the South American rattlesnake, Crotalus durissusArterial pressureBlood flowCardiac shuntReptilesSnakesVagus nerveVascular regulationThe undivided ventricle of non-crocodilian reptiles allows for intracardiac admixture of oxygen-poor and oxygen-rich blood returning via the atria from the systemic circuit and the lungs. The distribution of blood flow between the systemic and pulmonary circuits may vary, based on differences between systemic and pulmonary vascular conductances. The South American rattlesnake, Crotalus durissus, has a single pulmonary artery, innervated by the left vagus. Activity in this nerve controls pulmonary conductance so that left vagotomy abolishes this control. Experimental left vagotomy to abolish cardiac shunting had no effect on long-term survival and failed to identify a functional role in determining metabolic rate, growth or resistance to food deprivation. Accordingly, the present investigation sought to evaluate the extent to which cardiac shunt patterns are actively controlled during changes in body temperature and activity levels. We compared hemodynamic parameters between intact and left-vagotomized rattlesnakes held at different temperatures and subjected to enforced physical activity. Increased temperature and enforced activity raised heart rate, cardiac output, pulmonary and systemic blood flow in both groups, but net cardiac shunt was reversed in the vagotomized group at lower temperatures. We conclude that vagal control of pulmonary conductance is an active mechanism regulating cardiac shunts in C. durissus.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Zoology State University of São Paulo (UNESP)Zoophysiology Department of Bioscience Aarhus UniversitySchool of Biosciences University of BirminghamDepartment of Physiological Sciences Federal University of São Carlos (UFSCar)Department of Zoology State University of São Paulo (UNESP)Universidade Estadual Paulista (Unesp)Aarhus UniversityUniversity of BirminghamUniversidade Federal de São Carlos (UFSCar)Filogonio, Renato [UNESP]Wang, TobiasTaylor, Edwin W. [UNESP]Abe, Augusto S. [UNESP]Leite, Cléo A. C.2018-12-11T16:42:45Z2018-12-11T16:42:45Z2016-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1059-1066application/pdfhttp://dx.doi.org/10.1007/s00360-016-1008-yJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, v. 186, n. 8, p. 1059-1066, 2016.0174-1578http://hdl.handle.net/11449/16872910.1007/s00360-016-1008-y2-s2.0-849748295612-s2.0-84974829561.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology0,952info:eu-repo/semantics/openAccess2023-12-15T06:16:31Zoai:repositorio.unesp.br:11449/168729Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-15T06:16:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Vagal tone regulates cardiac shunts during activity and at low temperatures in the South American rattlesnake, Crotalus durissus |
title |
Vagal tone regulates cardiac shunts during activity and at low temperatures in the South American rattlesnake, Crotalus durissus |
spellingShingle |
Vagal tone regulates cardiac shunts during activity and at low temperatures in the South American rattlesnake, Crotalus durissus Filogonio, Renato [UNESP] Arterial pressure Blood flow Cardiac shunt Reptiles Snakes Vagus nerve Vascular regulation |
title_short |
Vagal tone regulates cardiac shunts during activity and at low temperatures in the South American rattlesnake, Crotalus durissus |
title_full |
Vagal tone regulates cardiac shunts during activity and at low temperatures in the South American rattlesnake, Crotalus durissus |
title_fullStr |
Vagal tone regulates cardiac shunts during activity and at low temperatures in the South American rattlesnake, Crotalus durissus |
title_full_unstemmed |
Vagal tone regulates cardiac shunts during activity and at low temperatures in the South American rattlesnake, Crotalus durissus |
title_sort |
Vagal tone regulates cardiac shunts during activity and at low temperatures in the South American rattlesnake, Crotalus durissus |
author |
Filogonio, Renato [UNESP] |
author_facet |
Filogonio, Renato [UNESP] Wang, Tobias Taylor, Edwin W. [UNESP] Abe, Augusto S. [UNESP] Leite, Cléo A. C. |
author_role |
author |
author2 |
Wang, Tobias Taylor, Edwin W. [UNESP] Abe, Augusto S. [UNESP] Leite, Cléo A. C. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Aarhus University University of Birmingham Universidade Federal de São Carlos (UFSCar) |
dc.contributor.author.fl_str_mv |
Filogonio, Renato [UNESP] Wang, Tobias Taylor, Edwin W. [UNESP] Abe, Augusto S. [UNESP] Leite, Cléo A. C. |
dc.subject.por.fl_str_mv |
Arterial pressure Blood flow Cardiac shunt Reptiles Snakes Vagus nerve Vascular regulation |
topic |
Arterial pressure Blood flow Cardiac shunt Reptiles Snakes Vagus nerve Vascular regulation |
description |
The undivided ventricle of non-crocodilian reptiles allows for intracardiac admixture of oxygen-poor and oxygen-rich blood returning via the atria from the systemic circuit and the lungs. The distribution of blood flow between the systemic and pulmonary circuits may vary, based on differences between systemic and pulmonary vascular conductances. The South American rattlesnake, Crotalus durissus, has a single pulmonary artery, innervated by the left vagus. Activity in this nerve controls pulmonary conductance so that left vagotomy abolishes this control. Experimental left vagotomy to abolish cardiac shunting had no effect on long-term survival and failed to identify a functional role in determining metabolic rate, growth or resistance to food deprivation. Accordingly, the present investigation sought to evaluate the extent to which cardiac shunt patterns are actively controlled during changes in body temperature and activity levels. We compared hemodynamic parameters between intact and left-vagotomized rattlesnakes held at different temperatures and subjected to enforced physical activity. Increased temperature and enforced activity raised heart rate, cardiac output, pulmonary and systemic blood flow in both groups, but net cardiac shunt was reversed in the vagotomized group at lower temperatures. We conclude that vagal control of pulmonary conductance is an active mechanism regulating cardiac shunts in C. durissus. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01 2018-12-11T16:42:45Z 2018-12-11T16:42:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00360-016-1008-y Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, v. 186, n. 8, p. 1059-1066, 2016. 0174-1578 http://hdl.handle.net/11449/168729 10.1007/s00360-016-1008-y 2-s2.0-84974829561 2-s2.0-84974829561.pdf |
url |
http://dx.doi.org/10.1007/s00360-016-1008-y http://hdl.handle.net/11449/168729 |
identifier_str_mv |
Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, v. 186, n. 8, p. 1059-1066, 2016. 0174-1578 10.1007/s00360-016-1008-y 2-s2.0-84974829561 2-s2.0-84974829561.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology 0,952 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1059-1066 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965292134137856 |