Osteonecrose relacionada aos bifosfonatos

• Autor(a) principal: Zago, Michelle Juliana Barbosa [UNESP]
• Data de Publicação: 2010
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149411; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-26/000851568.pdf
• topic: Osteonecrose; Difosfonatos; Odontologia; Osteonecrosis

Bisphosphonates are the drugs used in osteoporosis, bone metastases, multiple myeloma, hypercalcemia and Paget's disease of bone. However, with the growing use of this medication were reports of necrosis of the face's bones related to their use. This study analyzes the cases of two patients seen at the Oral Oncology Center of Univ Estadual Paulista - UNESP, Campus Araçatuba, diagnosed with bone necrosis. In the first clinical case the patient had bone metastases arising from prostate adenocarcinoma. He used bisphosphonates for a year associated with chemotherapeutic agents and corticosteroids. The patient was submitted hyperbaric oxygen therapy and requested transfer to another department where he underwent surgical resection with reconstruction with titaniun plate. In the second case the patient with multiple myeloma took bisphosphonate associated with Thalidomide and Venkad, was referred for evaluation of fistula in lower alveolar bone. On physical examination was noted bone exposure in the region of incisive papilla. The patient was monitored and submitted to a biopsy of the lesion in the mandibular body. Both patients died. Currently there is no consensus about the treatments recommended for bone necrosis associated with bisphosphonates because of this occurrence being observed with greater frequency recently. Therefore, further studies directed towards the development of bone necrosis should be performed in order to give the best care to patients who use bisphosphonates for the treatment of other diseases