Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1159/000493921 http://hdl.handle.net/11449/188253 |
Resumo: | Inflammatory bowel disease (IBD) affects young people of reproductive age. Therefore, a broad discussion is needed about the possible disease effects in pregnancy, as well as the risks of fetal exposure to the medications used, especially biological therapy. This study aimed to describe the management of 4 Crohn's disease patients who received anti-TNF therapy during pregnancy and present a literature review. We reported 4 cases composed of young women who became pregnant while receiving anti-TNF agents. The patients presented a satisfactory response to the clinical treatment and the pregnancies progressed without complications. We did not observe maternal or embryonic toxicity, or unfavorable outcomes. The available data point to inflammatory activity as the main risk factor for unfavorable gestational evolution to date, and showed anti-TNF therapy to be safe during pregnancy and breastfeeding. However, the benefits and risks must be discussed with the patient and management decisions should be taken on an individual basis. |
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Anti-TNF Exposure during Pregnancy in Crohn's Disease PatientsAnti-TNF therapyBiological therapyCrohn's diseaseInflammatory bowel diseasePregnancyInflammatory bowel disease (IBD) affects young people of reproductive age. Therefore, a broad discussion is needed about the possible disease effects in pregnancy, as well as the risks of fetal exposure to the medications used, especially biological therapy. This study aimed to describe the management of 4 Crohn's disease patients who received anti-TNF therapy during pregnancy and present a literature review. We reported 4 cases composed of young women who became pregnant while receiving anti-TNF agents. The patients presented a satisfactory response to the clinical treatment and the pregnancies progressed without complications. We did not observe maternal or embryonic toxicity, or unfavorable outcomes. The available data point to inflammatory activity as the main risk factor for unfavorable gestational evolution to date, and showed anti-TNF therapy to be safe during pregnancy and breastfeeding. However, the benefits and risks must be discussed with the patient and management decisions should be taken on an individual basis.Medical School Department of Internal Medicine São Paulo State University (UNESP), Av. Prof. Mario Rubens Guimaraes Montenegro, s/nMedical School Department of Surgery São Paulo State University (UNESP)Medical School Department of Internal Medicine São Paulo State University (UNESP), Av. Prof. Mario Rubens Guimaraes Montenegro, s/nMedical School Department of Surgery São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Silva, Elen Farinelli De Campos [UNESP]Baima, Júlio Pinheiro [UNESP]De Barros, Jaqueline Ribeiro [UNESP]Renosto, Fernanda Lofiego [UNESP]De Sibia, Carina De Fatima [UNESP]Saad-Hossne, Rogério [UNESP]Sassaki, Ligia Yukie [UNESP]2019-10-06T16:02:07Z2019-10-06T16:02:07Z2018-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article608-616http://dx.doi.org/10.1159/000493921Case Reports in Gastroenterology, v. 12, n. 3, p. 608-616, 2018.1662-0631http://hdl.handle.net/11449/18825310.1159/0004939212-s2.0-850554519984734747821898178Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCase Reports in Gastroenterologyinfo:eu-repo/semantics/openAccess2024-08-14T17:36:32Zoai:repositorio.unesp.br:11449/188253Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:36:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients |
title |
Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients |
spellingShingle |
Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients Silva, Elen Farinelli De Campos [UNESP] Anti-TNF therapy Biological therapy Crohn's disease Inflammatory bowel disease Pregnancy |
title_short |
Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients |
title_full |
Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients |
title_fullStr |
Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients |
title_full_unstemmed |
Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients |
title_sort |
Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients |
author |
Silva, Elen Farinelli De Campos [UNESP] |
author_facet |
Silva, Elen Farinelli De Campos [UNESP] Baima, Júlio Pinheiro [UNESP] De Barros, Jaqueline Ribeiro [UNESP] Renosto, Fernanda Lofiego [UNESP] De Sibia, Carina De Fatima [UNESP] Saad-Hossne, Rogério [UNESP] Sassaki, Ligia Yukie [UNESP] |
author_role |
author |
author2 |
Baima, Júlio Pinheiro [UNESP] De Barros, Jaqueline Ribeiro [UNESP] Renosto, Fernanda Lofiego [UNESP] De Sibia, Carina De Fatima [UNESP] Saad-Hossne, Rogério [UNESP] Sassaki, Ligia Yukie [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Silva, Elen Farinelli De Campos [UNESP] Baima, Júlio Pinheiro [UNESP] De Barros, Jaqueline Ribeiro [UNESP] Renosto, Fernanda Lofiego [UNESP] De Sibia, Carina De Fatima [UNESP] Saad-Hossne, Rogério [UNESP] Sassaki, Ligia Yukie [UNESP] |
dc.subject.por.fl_str_mv |
Anti-TNF therapy Biological therapy Crohn's disease Inflammatory bowel disease Pregnancy |
topic |
Anti-TNF therapy Biological therapy Crohn's disease Inflammatory bowel disease Pregnancy |
description |
Inflammatory bowel disease (IBD) affects young people of reproductive age. Therefore, a broad discussion is needed about the possible disease effects in pregnancy, as well as the risks of fetal exposure to the medications used, especially biological therapy. This study aimed to describe the management of 4 Crohn's disease patients who received anti-TNF therapy during pregnancy and present a literature review. We reported 4 cases composed of young women who became pregnant while receiving anti-TNF agents. The patients presented a satisfactory response to the clinical treatment and the pregnancies progressed without complications. We did not observe maternal or embryonic toxicity, or unfavorable outcomes. The available data point to inflammatory activity as the main risk factor for unfavorable gestational evolution to date, and showed anti-TNF therapy to be safe during pregnancy and breastfeeding. However, the benefits and risks must be discussed with the patient and management decisions should be taken on an individual basis. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09-01 2019-10-06T16:02:07Z 2019-10-06T16:02:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1159/000493921 Case Reports in Gastroenterology, v. 12, n. 3, p. 608-616, 2018. 1662-0631 http://hdl.handle.net/11449/188253 10.1159/000493921 2-s2.0-85055451998 4734747821898178 |
url |
http://dx.doi.org/10.1159/000493921 http://hdl.handle.net/11449/188253 |
identifier_str_mv |
Case Reports in Gastroenterology, v. 12, n. 3, p. 608-616, 2018. 1662-0631 10.1159/000493921 2-s2.0-85055451998 4734747821898178 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Case Reports in Gastroenterology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
608-616 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128195356000256 |