Paepalanthus spp: antimycobacterial activity of extracts, methoxylated flavonoids and naphthopyranone fractions

• Autor(a) principal: Moreira, Raquel Regina Duarte [UNESP]
• Data de Publicação: 2013
• Outros Autores: Martins, Gilmarcio Zimmermann [UNESP], Pietro, Rosemeire Cristina Linhari Rodrigues [UNESP], Sato, Daisy Nakamura [UNESP], Pavan, Fernando Rogério [UNESP], Leite, Sergio R. A. [UNESP], Vilegas, Wagner [UNESP], Leite, Clarice Queico Fujimura [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.sciencedirect.com/science/article/pii/S0102695X13700358; http://hdl.handle.net/11449/123633
• topic: flavonoids; Mycobacterium; naphthopyranone; Paepalanthus spp

Paepalanthus spp., Eriocaulaceae, are native plants from Brazil known as “sempre-vivas” (everlasting flowers). In this work, we evaluated the potential anti-mycobacterial activity of two methoxylated flavonoids (flavonoid 7-methylquercetagetin and 7-methylquercetagetin-4′-O-β-D-glucopyranoside) isolated and identified from P. latipes and the naphthopyranone fractions from P. bromeliodes ethanolic extracts. The MIC value of 500 μg/mL was verified for all compounds tested against M. tuberculosis H37Rv. For M. avium, the MIC value ranged from 1000–2000 μg/mL excepting to naphthopyranone fractions with MIC of 500 μg/mL. This is the first report of activity determination of Paepalanthus spp. flavonoids activity against Mycobacterium tuberculosis and M. avium.