Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods

Detalhes bibliográficos
Autor(a) principal: Forcato, Simone
Data de Publicação: 2019
Outros Autores: Montagnini, Bruno Garcia, Marino de Goes, Maria Luiza, Barrionuevo da Silva Novi, Daniella Regina, Inhasz Kiss, Ana Carolina, Ceravolo, Graziela Scalianti, Ceccatto Gerardin, Daniela Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.reprotox.2019.04.009
http://hdl.handle.net/11449/186223
Resumo: Metformin (MET) is a widely-used drug for the treatment of type 2 diabetes mellitus and gestational diabetes. It is known that metformin crosses the placenta and can to be transferred through milk. In vitro studies show that MET decreases gonadotropin-releasing hormone and gonadotropins release in rat neurons, and decreases progesterone and estradiol in rat granulosa cells and androstenedione synthesis in human theca cells. This study evaluated whether MET maternal exposure might interfere with reproductive parameters of female offspring. Wistar female rats were treated with MET 293 mg/kg/day, by gavage, from gestational day (GD) 0 to GD 21 (METG) or GD 0 until lactation day (LD) 21 (METGL). Controls groups received water. An increase in plasmatic estradiol levels was observed during the estrus stage in the METGL group. This result suggests that exposure to MET during gestational and lactational periods might be related to programming in theca and/or granulosa cells during development.
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spelling Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periodsAntidiabetic drugMaternal exposureEstrous cycleMetformin (MET) is a widely-used drug for the treatment of type 2 diabetes mellitus and gestational diabetes. It is known that metformin crosses the placenta and can to be transferred through milk. In vitro studies show that MET decreases gonadotropin-releasing hormone and gonadotropins release in rat neurons, and decreases progesterone and estradiol in rat granulosa cells and androstenedione synthesis in human theca cells. This study evaluated whether MET maternal exposure might interfere with reproductive parameters of female offspring. Wistar female rats were treated with MET 293 mg/kg/day, by gavage, from gestational day (GD) 0 to GD 21 (METG) or GD 0 until lactation day (LD) 21 (METGL). Controls groups received water. An increase in plasmatic estradiol levels was observed during the estrus stage in the METGL group. This result suggests that exposure to MET during gestational and lactational periods might be related to programming in theca and/or granulosa cells during development.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Londrina, PR, BrazilSeo Paulo State Univ, Dept Physiol, Botucatu, SP, BrazilElsevier B.V.Universidade Estadual de Londrina (UEL)Seo Paulo State UnivUniversidade Estadual Paulista (Unesp)Forcato, SimoneMontagnini, Bruno GarciaMarino de Goes, Maria LuizaBarrionuevo da Silva Novi, Daniella ReginaInhasz Kiss, Ana CarolinaCeravolo, Graziela ScaliantiCeccatto Gerardin, Daniela Cristina2019-10-04T13:15:54Z2019-10-04T13:15:54Z2019-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-7http://dx.doi.org/10.1016/j.reprotox.2019.04.009Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 87, p. 1-7, 2019.0890-6238http://hdl.handle.net/11449/18622310.1016/j.reprotox.2019.04.009WOS:000476575000001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproductive Toxicologyinfo:eu-repo/semantics/openAccess2021-10-23T03:22:31Zoai:repositorio.unesp.br:11449/186223Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:02:00.079856Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods
title Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods
spellingShingle Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods
Forcato, Simone
Antidiabetic drug
Maternal exposure
Estrous cycle
title_short Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods
title_full Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods
title_fullStr Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods
title_full_unstemmed Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods
title_sort Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods
author Forcato, Simone
author_facet Forcato, Simone
Montagnini, Bruno Garcia
Marino de Goes, Maria Luiza
Barrionuevo da Silva Novi, Daniella Regina
Inhasz Kiss, Ana Carolina
Ceravolo, Graziela Scalianti
Ceccatto Gerardin, Daniela Cristina
author_role author
author2 Montagnini, Bruno Garcia
Marino de Goes, Maria Luiza
Barrionuevo da Silva Novi, Daniella Regina
Inhasz Kiss, Ana Carolina
Ceravolo, Graziela Scalianti
Ceccatto Gerardin, Daniela Cristina
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Londrina (UEL)
Seo Paulo State Univ
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Forcato, Simone
Montagnini, Bruno Garcia
Marino de Goes, Maria Luiza
Barrionuevo da Silva Novi, Daniella Regina
Inhasz Kiss, Ana Carolina
Ceravolo, Graziela Scalianti
Ceccatto Gerardin, Daniela Cristina
dc.subject.por.fl_str_mv Antidiabetic drug
Maternal exposure
Estrous cycle
topic Antidiabetic drug
Maternal exposure
Estrous cycle
description Metformin (MET) is a widely-used drug for the treatment of type 2 diabetes mellitus and gestational diabetes. It is known that metformin crosses the placenta and can to be transferred through milk. In vitro studies show that MET decreases gonadotropin-releasing hormone and gonadotropins release in rat neurons, and decreases progesterone and estradiol in rat granulosa cells and androstenedione synthesis in human theca cells. This study evaluated whether MET maternal exposure might interfere with reproductive parameters of female offspring. Wistar female rats were treated with MET 293 mg/kg/day, by gavage, from gestational day (GD) 0 to GD 21 (METG) or GD 0 until lactation day (LD) 21 (METGL). Controls groups received water. An increase in plasmatic estradiol levels was observed during the estrus stage in the METGL group. This result suggests that exposure to MET during gestational and lactational periods might be related to programming in theca and/or granulosa cells during development.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-04T13:15:54Z
2019-10-04T13:15:54Z
2019-08-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.reprotox.2019.04.009
Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 87, p. 1-7, 2019.
0890-6238
http://hdl.handle.net/11449/186223
10.1016/j.reprotox.2019.04.009
WOS:000476575000001
url http://dx.doi.org/10.1016/j.reprotox.2019.04.009
http://hdl.handle.net/11449/186223
identifier_str_mv Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 87, p. 1-7, 2019.
0890-6238
10.1016/j.reprotox.2019.04.009
WOS:000476575000001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Reproductive Toxicology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-7
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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