Prospective study for the development of emulsion systems containing natural oil products

• Autor(a) principal: Xavier, F. H.
• Data de Publicação: 2012
• Outros Autores: Silva, K. G.H., Farias, I. E.G., Morais, A. R.V., Alencar, E. N., Araújo, I. B., Oliveira, A. G. [UNESP], Egito, E. S.T.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1016/s1773-2247(12)50061-4
• Texto Completo: http://dx.doi.org/10.1016/s1773-2247(12)50061-4; http://hdl.handle.net/11449/219833
• topic: Copaiba oil; Emulsion; Hydrophilic-lipophilic balance; Pseudo-ternary phase diagram; Stability analysis

Copaiba oil, when used as anti-inflammatory and anti-infective agent, presents two major problems: i) low absorption and bioavailability and ii) an unpleasant taste. Once an appropriate emulsion was achieved, the samples were prepared using different surfactant binary mixtures to obtain a range of HLB values between 45 and 16.5. The HLB value of copaiba oil was 14.8; this system has been stable for more than one year, and the pseudo-ternary diagrams were useful to describe the component proportions. These results indicated that the copaiba oil emulsion might be a promising vehicle for topical delivery of drugs and active cosmetic ingredients.