Microbiological assay for lomefloxacin in coated tablets

Detalhes bibliográficos
Autor(a) principal: Gomes, Greici Cristiani [UNESP]
Data de Publicação: 2006
Outros Autores: Salgado, Hérida Regina Nunes [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1093/jaoac/89.4.1077
http://hdl.handle.net/11449/231800
Resumo: The validation of a microbiological assay, applying cylinder plate method for determination of the activity of lomefloxacin in coated tablets is described. Using a strain of Bacillus subtilis ATCC 9372 as the test organism, lomefloxacin was measured in concentrations ranging from 2.0 to 8.0 μg/mL. The method validation showed that it is linear (r= 0.9999), precise (relative standard deviation = 1.15%), and accurate (it measured the added quantities). The excipients did not interfere in the determination. It was concluded that the microbiological assay is satisfactory for quantitation of lomefloxacin in tablets.
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spelling Microbiological assay for lomefloxacin in coated tabletsThe validation of a microbiological assay, applying cylinder plate method for determination of the activity of lomefloxacin in coated tablets is described. Using a strain of Bacillus subtilis ATCC 9372 as the test organism, lomefloxacin was measured in concentrations ranging from 2.0 to 8.0 μg/mL. The method validation showed that it is linear (r= 0.9999), precise (relative standard deviation = 1.15%), and accurate (it measured the added quantities). The excipients did not interfere in the determination. It was concluded that the microbiological assay is satisfactory for quantitation of lomefloxacin in tablets.Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SPUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SPUniversidade Estadual Paulista (UNESP)Gomes, Greici Cristiani [UNESP]Salgado, Hérida Regina Nunes [UNESP]2022-04-29T08:47:28Z2022-04-29T08:47:28Z2006-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1077-1079http://dx.doi.org/10.1093/jaoac/89.4.1077Journal of AOAC International, v. 89, n. 4, p. 1077-1079, 2006.1060-3271http://hdl.handle.net/11449/23180010.1093/jaoac/89.4.10772-s2.0-33750694271Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of AOAC Internationalinfo:eu-repo/semantics/openAccess2024-06-24T13:46:23Zoai:repositorio.unesp.br:11449/231800Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:44:08.796430Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Microbiological assay for lomefloxacin in coated tablets
title Microbiological assay for lomefloxacin in coated tablets
spellingShingle Microbiological assay for lomefloxacin in coated tablets
Gomes, Greici Cristiani [UNESP]
title_short Microbiological assay for lomefloxacin in coated tablets
title_full Microbiological assay for lomefloxacin in coated tablets
title_fullStr Microbiological assay for lomefloxacin in coated tablets
title_full_unstemmed Microbiological assay for lomefloxacin in coated tablets
title_sort Microbiological assay for lomefloxacin in coated tablets
author Gomes, Greici Cristiani [UNESP]
author_facet Gomes, Greici Cristiani [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
author_role author
author2 Salgado, Hérida Regina Nunes [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Gomes, Greici Cristiani [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
description The validation of a microbiological assay, applying cylinder plate method for determination of the activity of lomefloxacin in coated tablets is described. Using a strain of Bacillus subtilis ATCC 9372 as the test organism, lomefloxacin was measured in concentrations ranging from 2.0 to 8.0 μg/mL. The method validation showed that it is linear (r= 0.9999), precise (relative standard deviation = 1.15%), and accurate (it measured the added quantities). The excipients did not interfere in the determination. It was concluded that the microbiological assay is satisfactory for quantitation of lomefloxacin in tablets.
publishDate 2006
dc.date.none.fl_str_mv 2006-01-01
2022-04-29T08:47:28Z
2022-04-29T08:47:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1093/jaoac/89.4.1077
Journal of AOAC International, v. 89, n. 4, p. 1077-1079, 2006.
1060-3271
http://hdl.handle.net/11449/231800
10.1093/jaoac/89.4.1077
2-s2.0-33750694271
url http://dx.doi.org/10.1093/jaoac/89.4.1077
http://hdl.handle.net/11449/231800
identifier_str_mv Journal of AOAC International, v. 89, n. 4, p. 1077-1079, 2006.
1060-3271
10.1093/jaoac/89.4.1077
2-s2.0-33750694271
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of AOAC International
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1077-1079
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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