Estudo cromossômico no sangue periférico de pacientes com diferentes tipos de leucemia do Hospital de Base, São José do Rio Preto - SP
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/225295 |
Resumo: | The analysis of chromosomal changes in leukemia has had a direct involvement in the diagnosis, prognosis and treatment of patients Furthermore, it has allowed the understanding of biological processes involved in carcinogenesis. This work presents the results of a kariotypic study of 51 cases of different types of leukemia. The chromosomes were obtained through a 24 or 48 hour culture of cells of the peripheral blood with no mitogenic stimulation. In 74,5% of patients clonal chromosomic abnormalities were observed such as translocations, deletions, monosomies and trisomies. Many of the alterations were similar to results previously published and others were not such as the translocation involving the chromosomes 9 and 22, which leads to the Philadelphia chromosome and the complex translocation involving the chromosomes 4, 7 and 11. The results emphasized the importance of chromosomal analysis in leukemia, its benefits to the patient and to the knowledge of the biological mechanisms involved in this pathology. |
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Repositório Institucional da UNESP |
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Estudo cromossômico no sangue periférico de pacientes com diferentes tipos de leucemia do Hospital de Base, São José do Rio Preto - SPChromosomal study of peripheral blood in patients with different types of leukemia from Hospital de Base, São José do Rio Preto - SPChromosomic aberrationsCytogeneticLeukemiaThe analysis of chromosomal changes in leukemia has had a direct involvement in the diagnosis, prognosis and treatment of patients Furthermore, it has allowed the understanding of biological processes involved in carcinogenesis. This work presents the results of a kariotypic study of 51 cases of different types of leukemia. The chromosomes were obtained through a 24 or 48 hour culture of cells of the peripheral blood with no mitogenic stimulation. In 74,5% of patients clonal chromosomic abnormalities were observed such as translocations, deletions, monosomies and trisomies. Many of the alterations were similar to results previously published and others were not such as the translocation involving the chromosomes 9 and 22, which leads to the Philadelphia chromosome and the complex translocation involving the chromosomes 4, 7 and 11. The results emphasized the importance of chromosomal analysis in leukemia, its benefits to the patient and to the knowledge of the biological mechanisms involved in this pathology.Depto. de Biologia Molecular FAMERPDepto. de Biologia IBILCE-UNESPDepto. de Medicina FAMERPDepto. de Pediatria FAMERPFaculdade de Medicina de São José do Rio Preto Bairro Universitário, Av. Brigadeiro Faria Lima, 5416, São Josédo Rio Preto. SP. CEP 15090-000Depto. de Biologia IBILCE-UNESPFAMERPUniversidade Estadual Paulista (UNESP)Bairro UniversitárioFett-Conte, Agnes C.Vendrame-Goloni, Cristina B. [UNESP]Homsi, Carlos M.Borim, Leila N. B.Zola, Paulo A.Ricci, Octávio2022-04-28T20:44:03Z2022-04-28T20:44:03Z2000-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article374-386Revista Brasileira de Hematologia e Hemoterapia, v. 22, n. 3, p. 374-386, 2000.1516-8484http://hdl.handle.net/11449/2252952-s2.0-52849128612Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Hematologia e Hemoterapiainfo:eu-repo/semantics/openAccess2022-04-28T20:44:03Zoai:repositorio.unesp.br:11449/225295Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:48:35.510357Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Estudo cromossômico no sangue periférico de pacientes com diferentes tipos de leucemia do Hospital de Base, São José do Rio Preto - SP Chromosomal study of peripheral blood in patients with different types of leukemia from Hospital de Base, São José do Rio Preto - SP |
title |
Estudo cromossômico no sangue periférico de pacientes com diferentes tipos de leucemia do Hospital de Base, São José do Rio Preto - SP |
spellingShingle |
Estudo cromossômico no sangue periférico de pacientes com diferentes tipos de leucemia do Hospital de Base, São José do Rio Preto - SP Fett-Conte, Agnes C. Chromosomic aberrations Cytogenetic Leukemia |
title_short |
Estudo cromossômico no sangue periférico de pacientes com diferentes tipos de leucemia do Hospital de Base, São José do Rio Preto - SP |
title_full |
Estudo cromossômico no sangue periférico de pacientes com diferentes tipos de leucemia do Hospital de Base, São José do Rio Preto - SP |
title_fullStr |
Estudo cromossômico no sangue periférico de pacientes com diferentes tipos de leucemia do Hospital de Base, São José do Rio Preto - SP |
title_full_unstemmed |
Estudo cromossômico no sangue periférico de pacientes com diferentes tipos de leucemia do Hospital de Base, São José do Rio Preto - SP |
title_sort |
Estudo cromossômico no sangue periférico de pacientes com diferentes tipos de leucemia do Hospital de Base, São José do Rio Preto - SP |
author |
Fett-Conte, Agnes C. |
author_facet |
Fett-Conte, Agnes C. Vendrame-Goloni, Cristina B. [UNESP] Homsi, Carlos M. Borim, Leila N. B. Zola, Paulo A. Ricci, Octávio |
author_role |
author |
author2 |
Vendrame-Goloni, Cristina B. [UNESP] Homsi, Carlos M. Borim, Leila N. B. Zola, Paulo A. Ricci, Octávio |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
FAMERP Universidade Estadual Paulista (UNESP) Bairro Universitário |
dc.contributor.author.fl_str_mv |
Fett-Conte, Agnes C. Vendrame-Goloni, Cristina B. [UNESP] Homsi, Carlos M. Borim, Leila N. B. Zola, Paulo A. Ricci, Octávio |
dc.subject.por.fl_str_mv |
Chromosomic aberrations Cytogenetic Leukemia |
topic |
Chromosomic aberrations Cytogenetic Leukemia |
description |
The analysis of chromosomal changes in leukemia has had a direct involvement in the diagnosis, prognosis and treatment of patients Furthermore, it has allowed the understanding of biological processes involved in carcinogenesis. This work presents the results of a kariotypic study of 51 cases of different types of leukemia. The chromosomes were obtained through a 24 or 48 hour culture of cells of the peripheral blood with no mitogenic stimulation. In 74,5% of patients clonal chromosomic abnormalities were observed such as translocations, deletions, monosomies and trisomies. Many of the alterations were similar to results previously published and others were not such as the translocation involving the chromosomes 9 and 22, which leads to the Philadelphia chromosome and the complex translocation involving the chromosomes 4, 7 and 11. The results emphasized the importance of chromosomal analysis in leukemia, its benefits to the patient and to the knowledge of the biological mechanisms involved in this pathology. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-12-01 2022-04-28T20:44:03Z 2022-04-28T20:44:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia, v. 22, n. 3, p. 374-386, 2000. 1516-8484 http://hdl.handle.net/11449/225295 2-s2.0-52849128612 |
identifier_str_mv |
Revista Brasileira de Hematologia e Hemoterapia, v. 22, n. 3, p. 374-386, 2000. 1516-8484 2-s2.0-52849128612 |
url |
http://hdl.handle.net/11449/225295 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
374-386 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128983495081984 |