Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro

Detalhes bibliográficos
Autor(a) principal: Lavorato, Heloisa Lopes [UNESP]
Data de Publicação: 2012
Outros Autores: Petersen, Claudia G. [UNESP], Oliveira, Joao Batista A. [UNESP], Mauri, Ana L., Massaro, Fabiana C., Cavagna, Mario, Baruffi, Ricardo L. R., Franco Junior, Jose Gonçalves [UNESP]
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.jbra.com.br/archive/03.pdf
http://hdl.handle.net/11449/73569
Resumo: The agonists of gonadotropin-releasing hormone (GnRH) were introduced in ovarian stimulation for in vitro fertilization to avoid a premature surge of luteinizing hormone. Although they are accompanied by some disadvantages, GnRH agonists have become well accepted in clinical practice, and their use is associated with increased rates of pregnancy. The development of GnRH antagonists capable of blocking the pituitary immediately offered a therapeutic option. Comparative studies between the two analogs have suggested that the use of antagonists is associated with a shorter duration of ovulatory stimulus and a decreased incidence of ovarian hyperstimulation syndrome, while the type of GnRH analogues used show no significant effects on the rates of pregnancy and live birth. However, GnRH agonists have other applications in assisted reproductive technology cycles than the pituitary downregulation.
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spelling Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitroGnRH agonists, GnRH antagonists and assisted reproduction: GnRH analogues X IVFGnrh agonistsGnRH antagonistsIn vitro fertilizationOvarian stimulationgonadorelin agonistgonadorelin antagonistluteinizing hormonedown regulationfertilization in vitrohumanhypophysisinfertility therapylive birthluteinizing hormone releaseovary hyperstimulationovulation inductionpregnancy rateThe agonists of gonadotropin-releasing hormone (GnRH) were introduced in ovarian stimulation for in vitro fertilization to avoid a premature surge of luteinizing hormone. Although they are accompanied by some disadvantages, GnRH agonists have become well accepted in clinical practice, and their use is associated with increased rates of pregnancy. The development of GnRH antagonists capable of blocking the pituitary immediately offered a therapeutic option. Comparative studies between the two analogs have suggested that the use of antagonists is associated with a shorter duration of ovulatory stimulus and a decreased incidence of ovarian hyperstimulation syndrome, while the type of GnRH analogues used show no significant effects on the rates of pregnancy and live birth. However, GnRH agonists have other applications in assisted reproductive technology cycles than the pituitary downregulation.Departamento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu UnESP - Universidade Estadual Paulista Júlio de Mesquita Filho, BotucatuCentro de Reprodução Humana Professor Franco Jr, Ribeirão PretoCentro Paulista de Diagnóstico Pesquisa e Treinamento, Ribeirão PretoCentro de Referência da Saúde da Mulher Hospital Pérola Byington, Sao PauloDepartamento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu UnESP - Universidade Estadual Paulista Júlio de Mesquita Filho, BotucatuUniversidade Estadual Paulista (Unesp)Centro de Reprodução Humana Professor Franco JrPesquisa e TreinamentoHospital Pérola ByingtonLavorato, Heloisa Lopes [UNESP]Petersen, Claudia G. [UNESP]Oliveira, Joao Batista A. [UNESP]Mauri, Ana L.Massaro, Fabiana C.Cavagna, MarioBaruffi, Ricardo L. R.Franco Junior, Jose Gonçalves [UNESP]2014-05-27T11:26:59Z2014-05-27T11:26:59Z2012-09-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article91-96http://www.jbra.com.br/archive/03.pdfJornal Brasileiro de Reproducao Assistida, v. 16, n. 3, p. 91-96, 2012.1517-56931518-0557http://hdl.handle.net/11449/735692-s2.0-84865736177Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporJornal Brasileiro de Reproducao Assistida0,282info:eu-repo/semantics/openAccess2021-10-23T11:59:50Zoai:repositorio.unesp.br:11449/73569Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T11:59:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
GnRH agonists, GnRH antagonists and assisted reproduction: GnRH analogues X IVF
title Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
spellingShingle Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
Lavorato, Heloisa Lopes [UNESP]
Gnrh agonists
GnRH antagonists
In vitro fertilization
Ovarian stimulation
gonadorelin agonist
gonadorelin antagonist
luteinizing hormone
down regulation
fertilization in vitro
human
hypophysis
infertility therapy
live birth
luteinizing hormone release
ovary hyperstimulation
ovulation induction
pregnancy rate
title_short Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
title_full Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
title_fullStr Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
title_full_unstemmed Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
title_sort Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
author Lavorato, Heloisa Lopes [UNESP]
author_facet Lavorato, Heloisa Lopes [UNESP]
Petersen, Claudia G. [UNESP]
Oliveira, Joao Batista A. [UNESP]
Mauri, Ana L.
Massaro, Fabiana C.
Cavagna, Mario
Baruffi, Ricardo L. R.
Franco Junior, Jose Gonçalves [UNESP]
author_role author
author2 Petersen, Claudia G. [UNESP]
Oliveira, Joao Batista A. [UNESP]
Mauri, Ana L.
Massaro, Fabiana C.
Cavagna, Mario
Baruffi, Ricardo L. R.
Franco Junior, Jose Gonçalves [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Centro de Reprodução Humana Professor Franco Jr
Pesquisa e Treinamento
Hospital Pérola Byington
dc.contributor.author.fl_str_mv Lavorato, Heloisa Lopes [UNESP]
Petersen, Claudia G. [UNESP]
Oliveira, Joao Batista A. [UNESP]
Mauri, Ana L.
Massaro, Fabiana C.
Cavagna, Mario
Baruffi, Ricardo L. R.
Franco Junior, Jose Gonçalves [UNESP]
dc.subject.por.fl_str_mv Gnrh agonists
GnRH antagonists
In vitro fertilization
Ovarian stimulation
gonadorelin agonist
gonadorelin antagonist
luteinizing hormone
down regulation
fertilization in vitro
human
hypophysis
infertility therapy
live birth
luteinizing hormone release
ovary hyperstimulation
ovulation induction
pregnancy rate
topic Gnrh agonists
GnRH antagonists
In vitro fertilization
Ovarian stimulation
gonadorelin agonist
gonadorelin antagonist
luteinizing hormone
down regulation
fertilization in vitro
human
hypophysis
infertility therapy
live birth
luteinizing hormone release
ovary hyperstimulation
ovulation induction
pregnancy rate
description The agonists of gonadotropin-releasing hormone (GnRH) were introduced in ovarian stimulation for in vitro fertilization to avoid a premature surge of luteinizing hormone. Although they are accompanied by some disadvantages, GnRH agonists have become well accepted in clinical practice, and their use is associated with increased rates of pregnancy. The development of GnRH antagonists capable of blocking the pituitary immediately offered a therapeutic option. Comparative studies between the two analogs have suggested that the use of antagonists is associated with a shorter duration of ovulatory stimulus and a decreased incidence of ovarian hyperstimulation syndrome, while the type of GnRH analogues used show no significant effects on the rates of pregnancy and live birth. However, GnRH agonists have other applications in assisted reproductive technology cycles than the pituitary downregulation.
publishDate 2012
dc.date.none.fl_str_mv 2012-09-10
2014-05-27T11:26:59Z
2014-05-27T11:26:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.jbra.com.br/archive/03.pdf
Jornal Brasileiro de Reproducao Assistida, v. 16, n. 3, p. 91-96, 2012.
1517-5693
1518-0557
http://hdl.handle.net/11449/73569
2-s2.0-84865736177
url http://www.jbra.com.br/archive/03.pdf
http://hdl.handle.net/11449/73569
identifier_str_mv Jornal Brasileiro de Reproducao Assistida, v. 16, n. 3, p. 91-96, 2012.
1517-5693
1518-0557
2-s2.0-84865736177
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv Jornal Brasileiro de Reproducao Assistida
0,282
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 91-96
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965069475315712

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