Boron supplementation improves bone health of non-obese diabetic mice
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jtemb.2016.09.011 http://hdl.handle.net/11449/173613 |
Resumo: | Diabetes Mellitus is a condition that predisposes a higher risk for the development of osteoporosis. The objective of this study was to investigate the influence of boron supplementation on bone microstructure and strength in control and non-obese diabetic mice for 30 days. The animals were supplemented with 40 μg/0,5 ml of boron solution and controls received 0,5 ml of distilled water daily. We evaluated the biochemical parameters: total calcium, phosphorus, magnesium and boron; bone analysis: bone computed microtomography, and biomechanical assay with a three point test on the femur. This study consisted of 28 animals divided into four groups: Group water control - Ctrl (n = 10), Group boron control - Ctrl±B (n = 8), Group diabetic water - Diab (n = 5) and Group diabetic boron - Diab±B (n = 5). The results showed that cortical bone volume and the trabecular bone volume fraction were higher for Diab±B and Ctrl±B compared to the Diab and Ctrl groups (p ≤ 0,05). The trabecular specific bone surface was greater for the Diab±B group, and the trabecular thickness and structure model index had the worst values for the Diab group. The boron serum concentrations were higher for the Diab±B group compared to non-supplemented groups. The magnesium concentration was lower for Diab and Diab±B compared with controls. The biomechanical test on the femur revealed maintenance of parameters of the bone strength in animals Diab±B compared to the Diab group and controls. The results suggest that boron supplementation improves parameters related to bone strength and microstructure of cortical and trabecular bone in diabetic animals and the controls that were supplemented. |
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Repositório Institucional da UNESP |
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Boron supplementation improves bone health of non-obese diabetic miceBoneBoronOsteoporosisSupplementationDiabetes Mellitus is a condition that predisposes a higher risk for the development of osteoporosis. The objective of this study was to investigate the influence of boron supplementation on bone microstructure and strength in control and non-obese diabetic mice for 30 days. The animals were supplemented with 40 μg/0,5 ml of boron solution and controls received 0,5 ml of distilled water daily. We evaluated the biochemical parameters: total calcium, phosphorus, magnesium and boron; bone analysis: bone computed microtomography, and biomechanical assay with a three point test on the femur. This study consisted of 28 animals divided into four groups: Group water control - Ctrl (n = 10), Group boron control - Ctrl±B (n = 8), Group diabetic water - Diab (n = 5) and Group diabetic boron - Diab±B (n = 5). The results showed that cortical bone volume and the trabecular bone volume fraction were higher for Diab±B and Ctrl±B compared to the Diab and Ctrl groups (p ≤ 0,05). The trabecular specific bone surface was greater for the Diab±B group, and the trabecular thickness and structure model index had the worst values for the Diab group. The boron serum concentrations were higher for the Diab±B group compared to non-supplemented groups. The magnesium concentration was lower for Diab and Diab±B compared with controls. The biomechanical test on the femur revealed maintenance of parameters of the bone strength in animals Diab±B compared to the Diab group and controls. The results suggest that boron supplementation improves parameters related to bone strength and microstructure of cortical and trabecular bone in diabetic animals and the controls that were supplemented.Department of Food and Nutrition Faculty of Pharmaceutical Sciences State University of São Paulo-UNESPDepartment of Clinical Medicine Ribeirão Preto Medical School University of São Paulo-FMRP/USPBiomechanics Medicine and Rehabilitation School of Medicine of Ribeirão Preto University of São PauloDepartment of Food and Nutrition Faculty of Pharmaceutical Sciences State University of São Paulo-UNESPUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Dessordi, Renata [UNESP]Spirlandeli, Adriano LeviZamarioli, ArianeVolpon, José BatistaNavarro, Anderson Marliere2018-12-11T17:06:49Z2018-12-11T17:06:49Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article169-175application/pdfhttp://dx.doi.org/10.1016/j.jtemb.2016.09.011Journal of Trace Elements in Medicine and Biology, v. 39, p. 169-175.1878-32520946-672Xhttp://hdl.handle.net/11449/17361310.1016/j.jtemb.2016.09.0112-s2.0-849912882242-s2.0-84991288224.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Trace Elements in Medicine and Biologyinfo:eu-repo/semantics/openAccess2024-06-21T12:47:00Zoai:repositorio.unesp.br:11449/173613Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:59:04.243271Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Boron supplementation improves bone health of non-obese diabetic mice |
title |
Boron supplementation improves bone health of non-obese diabetic mice |
spellingShingle |
Boron supplementation improves bone health of non-obese diabetic mice Dessordi, Renata [UNESP] Bone Boron Osteoporosis Supplementation |
title_short |
Boron supplementation improves bone health of non-obese diabetic mice |
title_full |
Boron supplementation improves bone health of non-obese diabetic mice |
title_fullStr |
Boron supplementation improves bone health of non-obese diabetic mice |
title_full_unstemmed |
Boron supplementation improves bone health of non-obese diabetic mice |
title_sort |
Boron supplementation improves bone health of non-obese diabetic mice |
author |
Dessordi, Renata [UNESP] |
author_facet |
Dessordi, Renata [UNESP] Spirlandeli, Adriano Levi Zamarioli, Ariane Volpon, José Batista Navarro, Anderson Marliere |
author_role |
author |
author2 |
Spirlandeli, Adriano Levi Zamarioli, Ariane Volpon, José Batista Navarro, Anderson Marliere |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Dessordi, Renata [UNESP] Spirlandeli, Adriano Levi Zamarioli, Ariane Volpon, José Batista Navarro, Anderson Marliere |
dc.subject.por.fl_str_mv |
Bone Boron Osteoporosis Supplementation |
topic |
Bone Boron Osteoporosis Supplementation |
description |
Diabetes Mellitus is a condition that predisposes a higher risk for the development of osteoporosis. The objective of this study was to investigate the influence of boron supplementation on bone microstructure and strength in control and non-obese diabetic mice for 30 days. The animals were supplemented with 40 μg/0,5 ml of boron solution and controls received 0,5 ml of distilled water daily. We evaluated the biochemical parameters: total calcium, phosphorus, magnesium and boron; bone analysis: bone computed microtomography, and biomechanical assay with a three point test on the femur. This study consisted of 28 animals divided into four groups: Group water control - Ctrl (n = 10), Group boron control - Ctrl±B (n = 8), Group diabetic water - Diab (n = 5) and Group diabetic boron - Diab±B (n = 5). The results showed that cortical bone volume and the trabecular bone volume fraction were higher for Diab±B and Ctrl±B compared to the Diab and Ctrl groups (p ≤ 0,05). The trabecular specific bone surface was greater for the Diab±B group, and the trabecular thickness and structure model index had the worst values for the Diab group. The boron serum concentrations were higher for the Diab±B group compared to non-supplemented groups. The magnesium concentration was lower for Diab and Diab±B compared with controls. The biomechanical test on the femur revealed maintenance of parameters of the bone strength in animals Diab±B compared to the Diab group and controls. The results suggest that boron supplementation improves parameters related to bone strength and microstructure of cortical and trabecular bone in diabetic animals and the controls that were supplemented. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T17:06:49Z 2018-12-11T17:06:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jtemb.2016.09.011 Journal of Trace Elements in Medicine and Biology, v. 39, p. 169-175. 1878-3252 0946-672X http://hdl.handle.net/11449/173613 10.1016/j.jtemb.2016.09.011 2-s2.0-84991288224 2-s2.0-84991288224.pdf |
url |
http://dx.doi.org/10.1016/j.jtemb.2016.09.011 http://hdl.handle.net/11449/173613 |
identifier_str_mv |
Journal of Trace Elements in Medicine and Biology, v. 39, p. 169-175. 1878-3252 0946-672X 10.1016/j.jtemb.2016.09.011 2-s2.0-84991288224 2-s2.0-84991288224.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Trace Elements in Medicine and Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
169-175 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129007101673472 |