The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca

Detalhes bibliográficos
Autor(a) principal: Melo, Fernando L.
Data de Publicação: 2008
Outros Autores: Benati, Fabricio J., Roman, Walter Antonio [UNESP], Palazzo de Mello, Joao Carlos, Nozawa, Carlos, Carvalho Linhares, Rosa Elisa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.micres.2006.03.011
http://hdl.handle.net/11449/42556
Resumo: We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal ptant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 celts, and the 50% inhibitory concentration (IC50) were 22.01 mu g/ml (selectivity index (SI) = 2.83) and 21.10 mu g/mi (SI = 2.95), respectivety. At the highest concentration of the drug (40 mu g/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains. (C) 2006 Elsevier GmbH. All rights reserved.
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spelling The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiacaHeteropteris ophrodisiacaaliphatic nitro compoundpoliovirusantiviral activitybovine herpesvirusWe investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal ptant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 celts, and the 50% inhibitory concentration (IC50) were 22.01 mu g/ml (selectivity index (SI) = 2.83) and 21.10 mu g/mi (SI = 2.95), respectivety. At the highest concentration of the drug (40 mu g/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains. (C) 2006 Elsevier GmbH. All rights reserved.Universidade Estadual de Londrina (UEL), Dept Microbiol CCB, BR-86051990 Londrina, Parana, BrazilUniv Estadual Paulista, PPG Ciencias Farmaceut, Araraquara, SP, BrazilUniversidade Estadual de Maringá (UEM), Dept Farm & Farmacol, Maringa, Parana, BrazilUniv Estadual Paulista, PPG Ciencias Farmaceut, Araraquara, SP, BrazilElsevier Gmbh, Urban & Fischer VerlagUniversidade Estadual de Londrina (UEL)Universidade Estadual Paulista (Unesp)Universidade Estadual de Maringá (UEM)Melo, Fernando L.Benati, Fabricio J.Roman, Walter Antonio [UNESP]Palazzo de Mello, Joao CarlosNozawa, CarlosCarvalho Linhares, Rosa Elisa2014-05-20T15:34:30Z2014-05-20T15:34:30Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article136-139application/pdfhttp://dx.doi.org/10.1016/j.micres.2006.03.011Microbiological Research. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 163, n. 2, p. 136-139, 2008.0944-5013http://hdl.handle.net/11449/4255610.1016/j.micres.2006.03.011WOS:000254531400003WOS000254531400003.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMicrobiological Research2.7771,030info:eu-repo/semantics/openAccess2023-12-08T06:18:25Zoai:repositorio.unesp.br:11449/42556Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:45:33.113019Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca
title The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca
spellingShingle The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca
Melo, Fernando L.
Heteropteris ophrodisiaca
aliphatic nitro compound
poliovirus
antiviral activity
bovine herpesvirus
title_short The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca
title_full The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca
title_fullStr The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca
title_full_unstemmed The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca
title_sort The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca
author Melo, Fernando L.
author_facet Melo, Fernando L.
Benati, Fabricio J.
Roman, Walter Antonio [UNESP]
Palazzo de Mello, Joao Carlos
Nozawa, Carlos
Carvalho Linhares, Rosa Elisa
author_role author
author2 Benati, Fabricio J.
Roman, Walter Antonio [UNESP]
Palazzo de Mello, Joao Carlos
Nozawa, Carlos
Carvalho Linhares, Rosa Elisa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Londrina (UEL)
Universidade Estadual Paulista (Unesp)
Universidade Estadual de Maringá (UEM)
dc.contributor.author.fl_str_mv Melo, Fernando L.
Benati, Fabricio J.
Roman, Walter Antonio [UNESP]
Palazzo de Mello, Joao Carlos
Nozawa, Carlos
Carvalho Linhares, Rosa Elisa
dc.subject.por.fl_str_mv Heteropteris ophrodisiaca
aliphatic nitro compound
poliovirus
antiviral activity
bovine herpesvirus
topic Heteropteris ophrodisiaca
aliphatic nitro compound
poliovirus
antiviral activity
bovine herpesvirus
description We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal ptant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 celts, and the 50% inhibitory concentration (IC50) were 22.01 mu g/ml (selectivity index (SI) = 2.83) and 21.10 mu g/mi (SI = 2.95), respectivety. At the highest concentration of the drug (40 mu g/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains. (C) 2006 Elsevier GmbH. All rights reserved.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
2014-05-20T15:34:30Z
2014-05-20T15:34:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.micres.2006.03.011
Microbiological Research. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 163, n. 2, p. 136-139, 2008.
0944-5013
http://hdl.handle.net/11449/42556
10.1016/j.micres.2006.03.011
WOS:000254531400003
WOS000254531400003.pdf
url http://dx.doi.org/10.1016/j.micres.2006.03.011
http://hdl.handle.net/11449/42556
identifier_str_mv Microbiological Research. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 163, n. 2, p. 136-139, 2008.
0944-5013
10.1016/j.micres.2006.03.011
WOS:000254531400003
WOS000254531400003.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microbiological Research
2.777
1,030
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 136-139
application/pdf
dc.publisher.none.fl_str_mv Elsevier Gmbh, Urban & Fischer Verlag
publisher.none.fl_str_mv Elsevier Gmbh, Urban & Fischer Verlag
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129114369949696

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