Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia

Detalhes bibliográficos
Autor(a) principal: Blau, Lorena [UNESP]
Data de Publicação: 2006
Outros Autores: Menegon, Renato Farina [UNESP], Chin, Chung Man [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0100-40422006000600028
http://hdl.handle.net/11449/69198
Resumo: Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives.
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spelling Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapiaProdrug activation by enzyme, a promising strategy for chemotherapyCancerEnzymesProdrugsStrategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives.Departamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho, CP 502, 14801-902 Araraquara - SPDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho, CP 502, 14801-902 Araraquara - SPUniversidade Estadual Paulista (Unesp)Blau, Lorena [UNESP]Menegon, Renato Farina [UNESP]Chin, Chung Man [UNESP]2014-05-27T11:22:01Z2014-05-27T11:22:01Z2006-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1307-1316application/pdfhttp://dx.doi.org/10.1590/S0100-40422006000600028Quimica Nova, v. 29, n. 6, p. 1307-1316, 2006.0100-40421678-7064http://hdl.handle.net/11449/6919810.1590/S0100-40422006000600028S0100-40422006000600028WOS:0002423416000282-s2.0-338457165272-s2.0-33845716527.pdf97343336079754130000-0003-4141-0455Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporQuímica Nova0.6460,255info:eu-repo/semantics/openAccess2024-06-24T13:45:49Zoai:repositorio.unesp.br:11449/69198Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:25:21.656742Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
Prodrug activation by enzyme, a promising strategy for chemotherapy
title Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
spellingShingle Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
Blau, Lorena [UNESP]
Cancer
Enzymes
Prodrugs
title_short Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
title_full Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
title_fullStr Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
title_full_unstemmed Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
title_sort Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
author Blau, Lorena [UNESP]
author_facet Blau, Lorena [UNESP]
Menegon, Renato Farina [UNESP]
Chin, Chung Man [UNESP]
author_role author
author2 Menegon, Renato Farina [UNESP]
Chin, Chung Man [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Blau, Lorena [UNESP]
Menegon, Renato Farina [UNESP]
Chin, Chung Man [UNESP]
dc.subject.por.fl_str_mv Cancer
Enzymes
Prodrugs
topic Cancer
Enzymes
Prodrugs
description Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives.
publishDate 2006
dc.date.none.fl_str_mv 2006-11-01
2014-05-27T11:22:01Z
2014-05-27T11:22:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-40422006000600028
Quimica Nova, v. 29, n. 6, p. 1307-1316, 2006.
0100-4042
1678-7064
http://hdl.handle.net/11449/69198
10.1590/S0100-40422006000600028
S0100-40422006000600028
WOS:000242341600028
2-s2.0-33845716527
2-s2.0-33845716527.pdf
9734333607975413
0000-0003-4141-0455
url http://dx.doi.org/10.1590/S0100-40422006000600028
http://hdl.handle.net/11449/69198
identifier_str_mv Quimica Nova, v. 29, n. 6, p. 1307-1316, 2006.
0100-4042
1678-7064
10.1590/S0100-40422006000600028
S0100-40422006000600028
WOS:000242341600028
2-s2.0-33845716527
2-s2.0-33845716527.pdf
9734333607975413
0000-0003-4141-0455
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Química Nova
0.646
0,255
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1307-1316
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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