Non-conventional applications of computerized tomography: Analysis of solid dosage forms produced by pharmaceutical industry

Detalhes bibliográficos
Autor(a) principal: De Oliveira Jr., José Martins
Data de Publicação: 2010
Outros Autores: Germano Martins, Antonio César [UNESP]
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1063/1.3448008
http://hdl.handle.net/11449/71837
Resumo: X-ray computed tomography (CT) refers to the cross-sectional imaging of an object measuring the transmitted radiation at different directions. In this work, we describe a non-conventional application of computerized tomography: visualization and improvements in the understanding of some internal structural features of solid dosage forms. A micro-CT X-ray scanner, with a minimum resolution of 30 μm was used to characterize some pharmaceutical tablets, granules, controlled-release osmotic tablet and liquid-filled soft-gelatin capsules. The analysis presented in this work are essentially qualitative, but quantitative parameters, such as porosity, density distribution, tablets dimensions, etc. could also be obtained using the related CT techniques. © 2010 American Institute of Physics.
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spelling Non-conventional applications of computerized tomography: Analysis of solid dosage forms produced by pharmaceutical industryComputed TomographyGranulesSolid Dosage FormsTabletsX-rayX-ray computed tomography (CT) refers to the cross-sectional imaging of an object measuring the transmitted radiation at different directions. In this work, we describe a non-conventional application of computerized tomography: visualization and improvements in the understanding of some internal structural features of solid dosage forms. A micro-CT X-ray scanner, with a minimum resolution of 30 μm was used to characterize some pharmaceutical tablets, granules, controlled-release osmotic tablet and liquid-filled soft-gelatin capsules. The analysis presented in this work are essentially qualitative, but quantitative parameters, such as porosity, density distribution, tablets dimensions, etc. could also be obtained using the related CT techniques. © 2010 American Institute of Physics.Universidade de Sorocaba - UNISO Campus Trujillo, Av. Dr. General Osório, 35, Centro, 18060-000, Sorocaba, SPUniversidade Estadual Paulista Julio de Mesquita Filho - UNESP GASI, Av. 3 de Março, 511, Alto da Boa Vista, 18087-180, Sorocaba, SPUniversidade Estadual Paulista Julio de Mesquita Filho - UNESP GASI, Av. 3 de Março, 511, Alto da Boa Vista, 18087-180, Sorocaba, SPUniversidade de Sorocaba - UNISOUniversidade Estadual Paulista (Unesp)De Oliveira Jr., José MartinsGermano Martins, Antonio César [UNESP]2014-05-27T11:24:46Z2014-05-27T11:24:46Z2010-08-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject153-159application/pdfhttp://dx.doi.org/10.1063/1.3448008AIP Conference Proceedings, v. 1245, p. 153-159.0094-243X1551-7616http://hdl.handle.net/11449/7183710.1063/1.34480082-s2.0-779557923112-s2.0-77955792311.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAIP Conference Proceedingsinfo:eu-repo/semantics/openAccess2023-10-26T06:10:01Zoai:repositorio.unesp.br:11449/71837Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:02:51.160726Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Non-conventional applications of computerized tomography: Analysis of solid dosage forms produced by pharmaceutical industry
title Non-conventional applications of computerized tomography: Analysis of solid dosage forms produced by pharmaceutical industry
spellingShingle Non-conventional applications of computerized tomography: Analysis of solid dosage forms produced by pharmaceutical industry
De Oliveira Jr., José Martins
Computed Tomography
Granules
Solid Dosage Forms
Tablets
X-ray
title_short Non-conventional applications of computerized tomography: Analysis of solid dosage forms produced by pharmaceutical industry
title_full Non-conventional applications of computerized tomography: Analysis of solid dosage forms produced by pharmaceutical industry
title_fullStr Non-conventional applications of computerized tomography: Analysis of solid dosage forms produced by pharmaceutical industry
title_full_unstemmed Non-conventional applications of computerized tomography: Analysis of solid dosage forms produced by pharmaceutical industry
title_sort Non-conventional applications of computerized tomography: Analysis of solid dosage forms produced by pharmaceutical industry
author De Oliveira Jr., José Martins
author_facet De Oliveira Jr., José Martins
Germano Martins, Antonio César [UNESP]
author_role author
author2 Germano Martins, Antonio César [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade de Sorocaba - UNISO
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv De Oliveira Jr., José Martins
Germano Martins, Antonio César [UNESP]
dc.subject.por.fl_str_mv Computed Tomography
Granules
Solid Dosage Forms
Tablets
X-ray
topic Computed Tomography
Granules
Solid Dosage Forms
Tablets
X-ray
description X-ray computed tomography (CT) refers to the cross-sectional imaging of an object measuring the transmitted radiation at different directions. In this work, we describe a non-conventional application of computerized tomography: visualization and improvements in the understanding of some internal structural features of solid dosage forms. A micro-CT X-ray scanner, with a minimum resolution of 30 μm was used to characterize some pharmaceutical tablets, granules, controlled-release osmotic tablet and liquid-filled soft-gelatin capsules. The analysis presented in this work are essentially qualitative, but quantitative parameters, such as porosity, density distribution, tablets dimensions, etc. could also be obtained using the related CT techniques. © 2010 American Institute of Physics.
publishDate 2010
dc.date.none.fl_str_mv 2010-08-26
2014-05-27T11:24:46Z
2014-05-27T11:24:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1063/1.3448008
AIP Conference Proceedings, v. 1245, p. 153-159.
0094-243X
1551-7616
http://hdl.handle.net/11449/71837
10.1063/1.3448008
2-s2.0-77955792311
2-s2.0-77955792311.pdf
url http://dx.doi.org/10.1063/1.3448008
http://hdl.handle.net/11449/71837
identifier_str_mv AIP Conference Proceedings, v. 1245, p. 153-159.
0094-243X
1551-7616
10.1063/1.3448008
2-s2.0-77955792311
2-s2.0-77955792311.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv AIP Conference Proceedings
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 153-159
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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