Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating Tablets

Detalhes bibliográficos
Autor(a) principal: Arshad, Muhammad Sohail
Data de Publicação: 2022
Outros Autores: Chaudhary, Kiran, Mudassir, Jahanzeb, Farhan, Muhammad, Abbas, Nasir, Hussain, Amjad
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/204372
Resumo: The objective of the present investigation was to design, optimize and characterize the gastro retentive floating levofloxacin tablets and perform in-vivo evaluation using radiographic imaging. The floating tablets were prepared by using polymers i.e hydroxy propyl methyl cellulose (HPMC-K4M) and carbopol-940 individually and in combination by nonaquous granulation method. All the Formulations were evaluated for swelling index (S.I), floating behavior and in-vitro drug release kinetics. The compatibility study of levofloxacin with other polymers was investigated by FTIR, DSC, TGA and XRD. Results from FTIR and DSC revealed no chemical interaction amongst the formulation components. The optimized formulation (F11) showed floating lag time (FLT), total floating time (TFT) swelling index (S.I) of 60 sec, >16h and approximately 75 %, respectively. Moreover, F11 showed zero order levofloxacin release in simulated gastric fluid over the period of 6 h. X-ray studies showed that total buoyancy time was able to delay the gastric emptying of levofloxacin floating tablets in rabbits for more than 4 hours. In conclusion the optimized formulation (F11) can be used for the sustained delivery of levofloxacin for the treatment of peptic ulcer.
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spelling Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating TabletsGastroretentive dosage formsLevofloxacinFloating tabletsCarbopol 940 HPMC K4MThe objective of the present investigation was to design, optimize and characterize the gastro retentive floating levofloxacin tablets and perform in-vivo evaluation using radiographic imaging. The floating tablets were prepared by using polymers i.e hydroxy propyl methyl cellulose (HPMC-K4M) and carbopol-940 individually and in combination by nonaquous granulation method. All the Formulations were evaluated for swelling index (S.I), floating behavior and in-vitro drug release kinetics. The compatibility study of levofloxacin with other polymers was investigated by FTIR, DSC, TGA and XRD. Results from FTIR and DSC revealed no chemical interaction amongst the formulation components. The optimized formulation (F11) showed floating lag time (FLT), total floating time (TFT) swelling index (S.I) of 60 sec, >16h and approximately 75 %, respectively. Moreover, F11 showed zero order levofloxacin release in simulated gastric fluid over the period of 6 h. X-ray studies showed that total buoyancy time was able to delay the gastric emptying of levofloxacin floating tablets in rabbits for more than 4 hours. In conclusion the optimized formulation (F11) can be used for the sustained delivery of levofloxacin for the treatment of peptic ulcer.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2022-12-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20437210.1590/s2175-97902022e18630 Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/204372/194452Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessArshad, Muhammad Sohail Chaudhary, KiranMudassir, JahanzebFarhan, MuhammadAbbas, NasirHussain, Amjad2023-05-25T13:18:54Zoai:revistas.usp.br:article/204372Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-05-25T13:18:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating Tablets
title Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating Tablets
spellingShingle Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating Tablets
Arshad, Muhammad Sohail
Gastroretentive dosage forms
Levofloxacin
Floating tablets
Carbopol 940
HPMC K4M
title_short Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating Tablets
title_full Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating Tablets
title_fullStr Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating Tablets
title_full_unstemmed Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating Tablets
title_sort Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating Tablets
author Arshad, Muhammad Sohail
author_facet Arshad, Muhammad Sohail
Chaudhary, Kiran
Mudassir, Jahanzeb
Farhan, Muhammad
Abbas, Nasir
Hussain, Amjad
author_role author
author2 Chaudhary, Kiran
Mudassir, Jahanzeb
Farhan, Muhammad
Abbas, Nasir
Hussain, Amjad
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Arshad, Muhammad Sohail
Chaudhary, Kiran
Mudassir, Jahanzeb
Farhan, Muhammad
Abbas, Nasir
Hussain, Amjad
dc.subject.por.fl_str_mv Gastroretentive dosage forms
Levofloxacin
Floating tablets
Carbopol 940
HPMC K4M
topic Gastroretentive dosage forms
Levofloxacin
Floating tablets
Carbopol 940
HPMC K4M
description The objective of the present investigation was to design, optimize and characterize the gastro retentive floating levofloxacin tablets and perform in-vivo evaluation using radiographic imaging. The floating tablets were prepared by using polymers i.e hydroxy propyl methyl cellulose (HPMC-K4M) and carbopol-940 individually and in combination by nonaquous granulation method. All the Formulations were evaluated for swelling index (S.I), floating behavior and in-vitro drug release kinetics. The compatibility study of levofloxacin with other polymers was investigated by FTIR, DSC, TGA and XRD. Results from FTIR and DSC revealed no chemical interaction amongst the formulation components. The optimized formulation (F11) showed floating lag time (FLT), total floating time (TFT) swelling index (S.I) of 60 sec, >16h and approximately 75 %, respectively. Moreover, F11 showed zero order levofloxacin release in simulated gastric fluid over the period of 6 h. X-ray studies showed that total buoyancy time was able to delay the gastric emptying of levofloxacin floating tablets in rabbits for more than 4 hours. In conclusion the optimized formulation (F11) can be used for the sustained delivery of levofloxacin for the treatment of peptic ulcer.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-23
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/204372
10.1590/s2175-97902022e18630
url https://www.revistas.usp.br/bjps/article/view/204372
identifier_str_mv 10.1590/s2175-97902022e18630
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/204372/194452
dc.rights.driver.fl_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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