Reproductive changes in male rats treated perinatally with an aromatase inhibitor
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/224292 |
Resumo: | The effects of maternal exposure to aromatase inhibitor during the perinatal period of sexual brain differentiation were studied. The fertility was assessed in adult, male rat offspring of aromatase inhibitor-treated dams. The following results were obtained: (1) Sexual maturation, body weight, and wet weights of testis, pituitary, seminal vesicle, ventral prostate, and levatori ani muscle were unchanged at adult life. (2) Fifty percent of the animals were able to mate with normal females, which became pregnant but exhibited an increased number of preimplantation loss. (3) There was a decrease in the number of spermatozoa found in the testes and in the daily sperm production. (4) Of those, 25% of the male rats treated with aromatase inhibitor did not present male sexual behavior, showing female behavior when pretreated with estrogen. These results indicate that perinatal exposure to aromatase inhibitor during the critical period of male brain sexual differentiation has a long-term effect on the reproductive physiology and behavior of male rats. © 2002 Elsevier Science Inc. All rights reserved. |
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Repositório Institucional da UNESP |
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Reproductive changes in male rats treated perinatally with an aromatase inhibitorAromatase inhibitorBrain sexual differentiationFertilityRatReproductionSperm productionThe effects of maternal exposure to aromatase inhibitor during the perinatal period of sexual brain differentiation were studied. The fertility was assessed in adult, male rat offspring of aromatase inhibitor-treated dams. The following results were obtained: (1) Sexual maturation, body weight, and wet weights of testis, pituitary, seminal vesicle, ventral prostate, and levatori ani muscle were unchanged at adult life. (2) Fifty percent of the animals were able to mate with normal females, which became pregnant but exhibited an increased number of preimplantation loss. (3) There was a decrease in the number of spermatozoa found in the testes and in the daily sperm production. (4) Of those, 25% of the male rats treated with aromatase inhibitor did not present male sexual behavior, showing female behavior when pretreated with estrogen. These results indicate that perinatal exposure to aromatase inhibitor during the critical period of male brain sexual differentiation has a long-term effect on the reproductive physiology and behavior of male rats. © 2002 Elsevier Science Inc. All rights reserved.Department of Pharmacology Institute of Biosciences São Paulo State University, 18618-000 Botucatu, São PauloDepartment of Pharmacology Institute of Biosciences São Paulo State University, 18618-000 Botucatu, São PauloUniversidade Estadual Paulista (UNESP)Gerardin, Daniela C.C. [UNESP]Pereira, Oduvaldo C.M. [UNESP]2022-04-28T19:55:38Z2022-04-28T19:55:38Z2002-01-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article301-305Pharmacology Biochemistry and Behavior, v. 71, n. 1-2, p. 301-305, 2002.0091-3057http://hdl.handle.net/11449/2242922-s2.0-0037006012Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmacology Biochemistry and Behaviorinfo:eu-repo/semantics/openAccess2022-04-28T19:55:38Zoai:repositorio.unesp.br:11449/224292Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:55:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Reproductive changes in male rats treated perinatally with an aromatase inhibitor |
title |
Reproductive changes in male rats treated perinatally with an aromatase inhibitor |
spellingShingle |
Reproductive changes in male rats treated perinatally with an aromatase inhibitor Gerardin, Daniela C.C. [UNESP] Aromatase inhibitor Brain sexual differentiation Fertility Rat Reproduction Sperm production |
title_short |
Reproductive changes in male rats treated perinatally with an aromatase inhibitor |
title_full |
Reproductive changes in male rats treated perinatally with an aromatase inhibitor |
title_fullStr |
Reproductive changes in male rats treated perinatally with an aromatase inhibitor |
title_full_unstemmed |
Reproductive changes in male rats treated perinatally with an aromatase inhibitor |
title_sort |
Reproductive changes in male rats treated perinatally with an aromatase inhibitor |
author |
Gerardin, Daniela C.C. [UNESP] |
author_facet |
Gerardin, Daniela C.C. [UNESP] Pereira, Oduvaldo C.M. [UNESP] |
author_role |
author |
author2 |
Pereira, Oduvaldo C.M. [UNESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Gerardin, Daniela C.C. [UNESP] Pereira, Oduvaldo C.M. [UNESP] |
dc.subject.por.fl_str_mv |
Aromatase inhibitor Brain sexual differentiation Fertility Rat Reproduction Sperm production |
topic |
Aromatase inhibitor Brain sexual differentiation Fertility Rat Reproduction Sperm production |
description |
The effects of maternal exposure to aromatase inhibitor during the perinatal period of sexual brain differentiation were studied. The fertility was assessed in adult, male rat offspring of aromatase inhibitor-treated dams. The following results were obtained: (1) Sexual maturation, body weight, and wet weights of testis, pituitary, seminal vesicle, ventral prostate, and levatori ani muscle were unchanged at adult life. (2) Fifty percent of the animals were able to mate with normal females, which became pregnant but exhibited an increased number of preimplantation loss. (3) There was a decrease in the number of spermatozoa found in the testes and in the daily sperm production. (4) Of those, 25% of the male rats treated with aromatase inhibitor did not present male sexual behavior, showing female behavior when pretreated with estrogen. These results indicate that perinatal exposure to aromatase inhibitor during the critical period of male brain sexual differentiation has a long-term effect on the reproductive physiology and behavior of male rats. © 2002 Elsevier Science Inc. All rights reserved. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-01-02 2022-04-28T19:55:38Z 2022-04-28T19:55:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Pharmacology Biochemistry and Behavior, v. 71, n. 1-2, p. 301-305, 2002. 0091-3057 http://hdl.handle.net/11449/224292 2-s2.0-0037006012 |
identifier_str_mv |
Pharmacology Biochemistry and Behavior, v. 71, n. 1-2, p. 301-305, 2002. 0091-3057 2-s2.0-0037006012 |
url |
http://hdl.handle.net/11449/224292 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmacology Biochemistry and Behavior |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
301-305 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965544097513472 |