Day/night expression of MT1 and MT2 receptors in hypothalamic nuclei of the primate Sapajus apella
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Publication Date: | 2017 |
Other Authors: | , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1016/j.jchemneu.2017.01.005 http://hdl.handle.net/11449/178618 |
Summary: | Melatonin is involved in the temporal organization of several physiological and behavioral events, controlled by hypothalamic nuclei, like sleep, feeding, reproduction and metabolic modulation and acts through two types of high-affinity G protein-coupled membrane receptors: MT1 and MT2. This study aimed to investigate the expression of MT1 and MT2 receptors proteins in four hypothalamic nuclei, i.e., SCN, supraoptic (SON), paraventricular (PVN) and anteroventral periventricular nuclei (AVPV), of the diurnal primate Sapajus apella using immunohistochemistry. Since these areas are involved in the expression of biological rhythms, they are candidates to have variations in their neurochemistry, so the MT1 and MT2 expression has been analyzed at a point in light and another in the dark phase. Both receptors were found to have day/night differences in the four hypothalamic nuclei with an apparent inverse expression in the SCN compared with the other areas. These differences could be related to the idea that the individual should be prepared to respond by different ways to melatonin signal within the several processes and can contribute to the efficacy of melatonin ligands or melatonin in therapies. |
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Day/night expression of MT1 and MT2 receptors in hypothalamic nuclei of the primate Sapajus apellaBehaviorBiological rhythmsHypothalamusMelatoninMelatonin is involved in the temporal organization of several physiological and behavioral events, controlled by hypothalamic nuclei, like sleep, feeding, reproduction and metabolic modulation and acts through two types of high-affinity G protein-coupled membrane receptors: MT1 and MT2. This study aimed to investigate the expression of MT1 and MT2 receptors proteins in four hypothalamic nuclei, i.e., SCN, supraoptic (SON), paraventricular (PVN) and anteroventral periventricular nuclei (AVPV), of the diurnal primate Sapajus apella using immunohistochemistry. Since these areas are involved in the expression of biological rhythms, they are candidates to have variations in their neurochemistry, so the MT1 and MT2 expression has been analyzed at a point in light and another in the dark phase. Both receptors were found to have day/night differences in the four hypothalamic nuclei with an apparent inverse expression in the SCN compared with the other areas. These differences could be related to the idea that the individual should be prepared to respond by different ways to melatonin signal within the several processes and can contribute to the efficacy of melatonin ligands or melatonin in therapies.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University (UNESP), MariliaUniversity of Marilia (UNIMAR) Medical School, MariliaSão Paulo State University (UNESP)São Paulo State University (UNESP), MariliaSão Paulo State University (UNESP)FAPESP: 2011/51495-4Universidade Estadual Paulista (Unesp)Medical SchoolPinato, Luciana [UNESP]Ramos, DayaneHataka, Alessandre [UNESP]Rossignoli, Patricia S. [UNESP]Granado, Marcos DoniseteMazzetto, Marina CardosoCampos, Leila M.G. [UNESP]2018-12-11T17:31:20Z2018-12-11T17:31:20Z2017-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10-17application/pdfhttp://dx.doi.org/10.1016/j.jchemneu.2017.01.005Journal of Chemical Neuroanatomy, v. 81, p. 10-17.1873-63000891-0618http://hdl.handle.net/11449/17861810.1016/j.jchemneu.2017.01.0052-s2.0-850115852132-s2.0-85011585213.pdf262297545356308583723635911796240000-0001-6946-1145Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Chemical Neuroanatomy0,930info:eu-repo/semantics/openAccess2023-10-10T06:02:49Zoai:repositorio.unesp.br:11449/178618Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-10T06:02:49Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Day/night expression of MT1 and MT2 receptors in hypothalamic nuclei of the primate Sapajus apella |
title |
Day/night expression of MT1 and MT2 receptors in hypothalamic nuclei of the primate Sapajus apella |
spellingShingle |
Day/night expression of MT1 and MT2 receptors in hypothalamic nuclei of the primate Sapajus apella Pinato, Luciana [UNESP] Behavior Biological rhythms Hypothalamus Melatonin |
title_short |
Day/night expression of MT1 and MT2 receptors in hypothalamic nuclei of the primate Sapajus apella |
title_full |
Day/night expression of MT1 and MT2 receptors in hypothalamic nuclei of the primate Sapajus apella |
title_fullStr |
Day/night expression of MT1 and MT2 receptors in hypothalamic nuclei of the primate Sapajus apella |
title_full_unstemmed |
Day/night expression of MT1 and MT2 receptors in hypothalamic nuclei of the primate Sapajus apella |
title_sort |
Day/night expression of MT1 and MT2 receptors in hypothalamic nuclei of the primate Sapajus apella |
author |
Pinato, Luciana [UNESP] |
author_facet |
Pinato, Luciana [UNESP] Ramos, Dayane Hataka, Alessandre [UNESP] Rossignoli, Patricia S. [UNESP] Granado, Marcos Donisete Mazzetto, Marina Cardoso Campos, Leila M.G. [UNESP] |
author_role |
author |
author2 |
Ramos, Dayane Hataka, Alessandre [UNESP] Rossignoli, Patricia S. [UNESP] Granado, Marcos Donisete Mazzetto, Marina Cardoso Campos, Leila M.G. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Medical School |
dc.contributor.author.fl_str_mv |
Pinato, Luciana [UNESP] Ramos, Dayane Hataka, Alessandre [UNESP] Rossignoli, Patricia S. [UNESP] Granado, Marcos Donisete Mazzetto, Marina Cardoso Campos, Leila M.G. [UNESP] |
dc.subject.por.fl_str_mv |
Behavior Biological rhythms Hypothalamus Melatonin |
topic |
Behavior Biological rhythms Hypothalamus Melatonin |
description |
Melatonin is involved in the temporal organization of several physiological and behavioral events, controlled by hypothalamic nuclei, like sleep, feeding, reproduction and metabolic modulation and acts through two types of high-affinity G protein-coupled membrane receptors: MT1 and MT2. This study aimed to investigate the expression of MT1 and MT2 receptors proteins in four hypothalamic nuclei, i.e., SCN, supraoptic (SON), paraventricular (PVN) and anteroventral periventricular nuclei (AVPV), of the diurnal primate Sapajus apella using immunohistochemistry. Since these areas are involved in the expression of biological rhythms, they are candidates to have variations in their neurochemistry, so the MT1 and MT2 expression has been analyzed at a point in light and another in the dark phase. Both receptors were found to have day/night differences in the four hypothalamic nuclei with an apparent inverse expression in the SCN compared with the other areas. These differences could be related to the idea that the individual should be prepared to respond by different ways to melatonin signal within the several processes and can contribute to the efficacy of melatonin ligands or melatonin in therapies. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-01 2018-12-11T17:31:20Z 2018-12-11T17:31:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jchemneu.2017.01.005 Journal of Chemical Neuroanatomy, v. 81, p. 10-17. 1873-6300 0891-0618 http://hdl.handle.net/11449/178618 10.1016/j.jchemneu.2017.01.005 2-s2.0-85011585213 2-s2.0-85011585213.pdf 2622975453563085 8372363591179624 0000-0001-6946-1145 |
url |
http://dx.doi.org/10.1016/j.jchemneu.2017.01.005 http://hdl.handle.net/11449/178618 |
identifier_str_mv |
Journal of Chemical Neuroanatomy, v. 81, p. 10-17. 1873-6300 0891-0618 10.1016/j.jchemneu.2017.01.005 2-s2.0-85011585213 2-s2.0-85011585213.pdf 2622975453563085 8372363591179624 0000-0001-6946-1145 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Chemical Neuroanatomy 0,930 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10-17 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964503030366208 |