Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.14393/BJ-v34n1a2018-39403 http://hdl.handle.net/11449/221139 |
Resumo: | This study aims to examine the effects of physical training performed in early (preventive) or late (therapeutic) protocols on body weight gain, glucose tolerance, and triglycerides accumulation in rats fed on a fructose-rich diet. Wistar rats were allocated into two major groups according to the diet received: Control (C-standard diet) and Fructose (F-diet containing 60% fructose) fed during 120 days. Next, these two groups were distributed into six groups: C and F that were kept inactive; CTE (Control Trained Early) and FTE (Fructose Trained Early) that were submitted to Anaerobic Threshold (AnT) training from 28 to 120 days; CTL (Control Trained Late) and FTL (Fructose Trained Late) trained from 90 to 120 days. Physical Training was composed by swimming (5 days/week) at AnT determined by maximum lactate stead state (MLSS). The Oral Glucose Tolerance Test (oGTT) was performed 48h after the last in vivo analysis and did not showed differences between the groups. After, the animals were euthanized for heart, liver, and adipose tissue extraction. The early exercised animals had lower body weight compared to their sedentary littermates. Also, the fructose-rich diet increased liver lipids content in the sedentary animals and physical training successfully reduced this parameter in both major groups. These results suggests that physical training at the AnT performed in early or late protocols are effective to prevent and treat metabolic disorders related to fructose intake. |
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Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich dietTreinamento físico previne e trata acumulação lipídica hepática induzida por dieta rica em frutoseAdiposityHepatic steatosisOverweightPhysical exerciseThis study aims to examine the effects of physical training performed in early (preventive) or late (therapeutic) protocols on body weight gain, glucose tolerance, and triglycerides accumulation in rats fed on a fructose-rich diet. Wistar rats were allocated into two major groups according to the diet received: Control (C-standard diet) and Fructose (F-diet containing 60% fructose) fed during 120 days. Next, these two groups were distributed into six groups: C and F that were kept inactive; CTE (Control Trained Early) and FTE (Fructose Trained Early) that were submitted to Anaerobic Threshold (AnT) training from 28 to 120 days; CTL (Control Trained Late) and FTL (Fructose Trained Late) trained from 90 to 120 days. Physical Training was composed by swimming (5 days/week) at AnT determined by maximum lactate stead state (MLSS). The Oral Glucose Tolerance Test (oGTT) was performed 48h after the last in vivo analysis and did not showed differences between the groups. After, the animals were euthanized for heart, liver, and adipose tissue extraction. The early exercised animals had lower body weight compared to their sedentary littermates. Also, the fructose-rich diet increased liver lipids content in the sedentary animals and physical training successfully reduced this parameter in both major groups. These results suggests that physical training at the AnT performed in early or late protocols are effective to prevent and treat metabolic disorders related to fructose intake.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Nutrition Metabolism and Exercise University of Campinas (UNICAMP)Universidade Estadual Paulista Julio de Mesquita FilhoMedical Sciences University University of Campinas (UNICAMP)Department of Physical Education Federal University of Mato Grosso (UFMT)Department of Physical Education Catholic University Center Auxilium UniSalesianoUniversidade Estadual Paulista Julio de Mesquita FilhoFAPESP: 2013/20293-2Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Federal University of Mato Grosso (UFMT)Catholic University Center Auxilium UniSalesianoGaspar, Rafael CalaisKuga, Gabriel Keine [UNESP]Muñoz, Vitor RosettoCoope, AndressaCambri, Lucieli TeresaGhezzi, Ana CarolinaMoura, Leandro Pereira de [UNESP]Leme, José Alexandre Curiacos de AlmeidaPauli, José RodrigoBotezelli, José Diego2022-04-28T19:10:59Z2022-04-28T19:10:59Z2018-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1041-1050http://dx.doi.org/10.14393/BJ-v34n1a2018-39403Bioscience Journal, v. 34, n. 4, p. 1041-1050, 2018.1981-31631516-3725http://hdl.handle.net/11449/22113910.14393/BJ-v34n1a2018-394032-s2.0-85051445018Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioscience Journalinfo:eu-repo/semantics/openAccess2022-04-28T19:10:59Zoai:repositorio.unesp.br:11449/221139Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:00:18.280081Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet Treinamento físico previne e trata acumulação lipídica hepática induzida por dieta rica em frutose |
title |
Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet |
spellingShingle |
Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet Gaspar, Rafael Calais Adiposity Hepatic steatosis Overweight Physical exercise |
title_short |
Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet |
title_full |
Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet |
title_fullStr |
Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet |
title_full_unstemmed |
Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet |
title_sort |
Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet |
author |
Gaspar, Rafael Calais |
author_facet |
Gaspar, Rafael Calais Kuga, Gabriel Keine [UNESP] Muñoz, Vitor Rosetto Coope, Andressa Cambri, Lucieli Teresa Ghezzi, Ana Carolina Moura, Leandro Pereira de [UNESP] Leme, José Alexandre Curiacos de Almeida Pauli, José Rodrigo Botezelli, José Diego |
author_role |
author |
author2 |
Kuga, Gabriel Keine [UNESP] Muñoz, Vitor Rosetto Coope, Andressa Cambri, Lucieli Teresa Ghezzi, Ana Carolina Moura, Leandro Pereira de [UNESP] Leme, José Alexandre Curiacos de Almeida Pauli, José Rodrigo Botezelli, José Diego |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (UNESP) Federal University of Mato Grosso (UFMT) Catholic University Center Auxilium UniSalesiano |
dc.contributor.author.fl_str_mv |
Gaspar, Rafael Calais Kuga, Gabriel Keine [UNESP] Muñoz, Vitor Rosetto Coope, Andressa Cambri, Lucieli Teresa Ghezzi, Ana Carolina Moura, Leandro Pereira de [UNESP] Leme, José Alexandre Curiacos de Almeida Pauli, José Rodrigo Botezelli, José Diego |
dc.subject.por.fl_str_mv |
Adiposity Hepatic steatosis Overweight Physical exercise |
topic |
Adiposity Hepatic steatosis Overweight Physical exercise |
description |
This study aims to examine the effects of physical training performed in early (preventive) or late (therapeutic) protocols on body weight gain, glucose tolerance, and triglycerides accumulation in rats fed on a fructose-rich diet. Wistar rats were allocated into two major groups according to the diet received: Control (C-standard diet) and Fructose (F-diet containing 60% fructose) fed during 120 days. Next, these two groups were distributed into six groups: C and F that were kept inactive; CTE (Control Trained Early) and FTE (Fructose Trained Early) that were submitted to Anaerobic Threshold (AnT) training from 28 to 120 days; CTL (Control Trained Late) and FTL (Fructose Trained Late) trained from 90 to 120 days. Physical Training was composed by swimming (5 days/week) at AnT determined by maximum lactate stead state (MLSS). The Oral Glucose Tolerance Test (oGTT) was performed 48h after the last in vivo analysis and did not showed differences between the groups. After, the animals were euthanized for heart, liver, and adipose tissue extraction. The early exercised animals had lower body weight compared to their sedentary littermates. Also, the fructose-rich diet increased liver lipids content in the sedentary animals and physical training successfully reduced this parameter in both major groups. These results suggests that physical training at the AnT performed in early or late protocols are effective to prevent and treat metabolic disorders related to fructose intake. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-01 2022-04-28T19:10:59Z 2022-04-28T19:10:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.14393/BJ-v34n1a2018-39403 Bioscience Journal, v. 34, n. 4, p. 1041-1050, 2018. 1981-3163 1516-3725 http://hdl.handle.net/11449/221139 10.14393/BJ-v34n1a2018-39403 2-s2.0-85051445018 |
url |
http://dx.doi.org/10.14393/BJ-v34n1a2018-39403 http://hdl.handle.net/11449/221139 |
identifier_str_mv |
Bioscience Journal, v. 34, n. 4, p. 1041-1050, 2018. 1981-3163 1516-3725 10.14393/BJ-v34n1a2018-39403 2-s2.0-85051445018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bioscience Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1041-1050 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128591558344704 |