beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jff.2010.11.001 http://hdl.handle.net/11449/7210 |
Resumo: | The hypocholesterolemic effect of isolated soybean proteins and fenofibrate in rats was compared Forty five rats were divided into five groups standard (STD casein) high cholesterol (HC STD plus 1% cholesterol/0 5% cholic acid) HC + beta conglycinin HC + glycinin and HC + fenofibrate The proteins and the drug were administered by gavage for 28 days The proteins decreased total cholesterol (TC) and triacylglycerol (TG) in the plasma of the rats fed HC diet to values very close to those fed on fenofibrate High density lipoprotein cholesterol (HDL C) levels in the plasma were increased by the beta conglycinin glycinin and fenofibrate groups The largest TC reduction in the liver was observed in the fenofibrate group, in contrast the beta conglycinin and glycinin groups exhibited reduced the levels of hepatic TG and TC Based on these data it could be suggested that the oral daily administration of isolated soybean proteins in the range of 2 75% of the protein ingested daily can promote a reduction in TC and TG in the plasma of rats fed hypercholesterolemic diets Crown Copyright (C) 2010 Published by Elsevier Ltd All rights reserved |
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beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol dietbeta ConglycininGlycininFenofibrateHypercholesterolemic dietDyslipidemiaRatsThe hypocholesterolemic effect of isolated soybean proteins and fenofibrate in rats was compared Forty five rats were divided into five groups standard (STD casein) high cholesterol (HC STD plus 1% cholesterol/0 5% cholic acid) HC + beta conglycinin HC + glycinin and HC + fenofibrate The proteins and the drug were administered by gavage for 28 days The proteins decreased total cholesterol (TC) and triacylglycerol (TG) in the plasma of the rats fed HC diet to values very close to those fed on fenofibrate High density lipoprotein cholesterol (HDL C) levels in the plasma were increased by the beta conglycinin glycinin and fenofibrate groups The largest TC reduction in the liver was observed in the fenofibrate group, in contrast the beta conglycinin and glycinin groups exhibited reduced the levels of hepatic TG and TC Based on these data it could be suggested that the oral daily administration of isolated soybean proteins in the range of 2 75% of the protein ingested daily can promote a reduction in TC and TG in the plasma of rats fed hypercholesterolemic diets Crown Copyright (C) 2010 Published by Elsevier Ltd All rights reservedCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação para o Desenvolvimento da UNESP (FUNDUNESP)São Paulo State Univ UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, BrazilSão Paulo State Univ UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, BrazilFUNDUNESP: 00583/07-DFPFUNDUNESP: 0041/10-DFPElsevier B.V.Universidade Estadual Paulista (Unesp)Ferreira, Ederlan de Souza [UNESP]Silva, Maraiza Aparecida [UNESP]Demonte, Aureluce [UNESP]Neves, Valdir Augusto [UNESP]2014-05-20T13:23:44Z2014-05-20T13:23:44Z2010-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article275-283application/pdfhttp://dx.doi.org/10.1016/j.jff.2010.11.001Journal of Functional Foods. Amsterdam: Elsevier B.V., v. 2, n. 4, p. 275-283, 2010.1756-4646http://hdl.handle.net/11449/721010.1016/j.jff.2010.11.001WOS:000285234400007WOS000285234400007.pdf52699697678453534031319519910419Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Functional Foods3.4701,245info:eu-repo/semantics/openAccess2024-06-21T12:46:49Zoai:repositorio.unesp.br:11449/7210Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-21T12:46:49Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet |
title |
beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet |
spellingShingle |
beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet Ferreira, Ederlan de Souza [UNESP] beta Conglycinin Glycinin Fenofibrate Hypercholesterolemic diet Dyslipidemia Rats |
title_short |
beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet |
title_full |
beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet |
title_fullStr |
beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet |
title_full_unstemmed |
beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet |
title_sort |
beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet |
author |
Ferreira, Ederlan de Souza [UNESP] |
author_facet |
Ferreira, Ederlan de Souza [UNESP] Silva, Maraiza Aparecida [UNESP] Demonte, Aureluce [UNESP] Neves, Valdir Augusto [UNESP] |
author_role |
author |
author2 |
Silva, Maraiza Aparecida [UNESP] Demonte, Aureluce [UNESP] Neves, Valdir Augusto [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ferreira, Ederlan de Souza [UNESP] Silva, Maraiza Aparecida [UNESP] Demonte, Aureluce [UNESP] Neves, Valdir Augusto [UNESP] |
dc.subject.por.fl_str_mv |
beta Conglycinin Glycinin Fenofibrate Hypercholesterolemic diet Dyslipidemia Rats |
topic |
beta Conglycinin Glycinin Fenofibrate Hypercholesterolemic diet Dyslipidemia Rats |
description |
The hypocholesterolemic effect of isolated soybean proteins and fenofibrate in rats was compared Forty five rats were divided into five groups standard (STD casein) high cholesterol (HC STD plus 1% cholesterol/0 5% cholic acid) HC + beta conglycinin HC + glycinin and HC + fenofibrate The proteins and the drug were administered by gavage for 28 days The proteins decreased total cholesterol (TC) and triacylglycerol (TG) in the plasma of the rats fed HC diet to values very close to those fed on fenofibrate High density lipoprotein cholesterol (HDL C) levels in the plasma were increased by the beta conglycinin glycinin and fenofibrate groups The largest TC reduction in the liver was observed in the fenofibrate group, in contrast the beta conglycinin and glycinin groups exhibited reduced the levels of hepatic TG and TC Based on these data it could be suggested that the oral daily administration of isolated soybean proteins in the range of 2 75% of the protein ingested daily can promote a reduction in TC and TG in the plasma of rats fed hypercholesterolemic diets Crown Copyright (C) 2010 Published by Elsevier Ltd All rights reserved |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-10-01 2014-05-20T13:23:44Z 2014-05-20T13:23:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jff.2010.11.001 Journal of Functional Foods. Amsterdam: Elsevier B.V., v. 2, n. 4, p. 275-283, 2010. 1756-4646 http://hdl.handle.net/11449/7210 10.1016/j.jff.2010.11.001 WOS:000285234400007 WOS000285234400007.pdf 5269969767845353 4031319519910419 |
url |
http://dx.doi.org/10.1016/j.jff.2010.11.001 http://hdl.handle.net/11449/7210 |
identifier_str_mv |
Journal of Functional Foods. Amsterdam: Elsevier B.V., v. 2, n. 4, p. 275-283, 2010. 1756-4646 10.1016/j.jff.2010.11.001 WOS:000285234400007 WOS000285234400007.pdf 5269969767845353 4031319519910419 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Functional Foods 3.470 1,245 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
275-283 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803649634614116352 |