Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine
Main Author: | |
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Publication Date: | 2019 |
Other Authors: | , , , , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1016/j.ijbiomac.2019.01.206 http://hdl.handle.net/11449/188714 |
Summary: | The natural alkaloid epiisopiloturine has recently become the focus of study for various medicinal properties, particularly for its anti-inflammatory and antischistosomal effect. The incorporation of active molecules in natural polymeric matrices has garnered increasing interest during recent decades. A new derivative of cashew gum successfully obtained by gum acetylation has shown great potential as a carrier in controlled drug release systems. In this work, epiisopiloturine was encapsulated in acetylated cashew gum nanoparticles in order to increase solubility and allow slow release, whereas the morphology results were supported by computer simulations. The particles were produced under a variety of conditions, and thoroughly characterized using light scattering and microscopic techniques. The particles were spherical and highly stable in solution, and showed drug incorporation at high levels, up to 55% efficiency. Using a dialysis-based in vitro assay, these particles were shown to release the drug via a Fickian diffusion mechanism, leading to gradual drug release over approximately 6 h. These nanoparticles show potential for the use as drug delivery system, while studies on their potential anti-inflammatory action, as well as toxicity and efficacy assays would need to be performed in the future to confirm their suitability as drug delivery candidates. |
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Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturineAcetic anhydride (PubChem CID: 7918)Acetone (PubChem CID: 180)AcetylationAlkaloidCashew gumFormamide (PubChem CID: 713)Hydrochloric acid (PubChem CID: 313)Pyridine (PubChem CID: 1049)Sodium hydroxide (PubChem CID: 14798)The natural alkaloid epiisopiloturine has recently become the focus of study for various medicinal properties, particularly for its anti-inflammatory and antischistosomal effect. The incorporation of active molecules in natural polymeric matrices has garnered increasing interest during recent decades. A new derivative of cashew gum successfully obtained by gum acetylation has shown great potential as a carrier in controlled drug release systems. In this work, epiisopiloturine was encapsulated in acetylated cashew gum nanoparticles in order to increase solubility and allow slow release, whereas the morphology results were supported by computer simulations. The particles were produced under a variety of conditions, and thoroughly characterized using light scattering and microscopic techniques. The particles were spherical and highly stable in solution, and showed drug incorporation at high levels, up to 55% efficiency. Using a dialysis-based in vitro assay, these particles were shown to release the drug via a Fickian diffusion mechanism, leading to gradual drug release over approximately 6 h. These nanoparticles show potential for the use as drug delivery system, while studies on their potential anti-inflammatory action, as well as toxicity and efficacy assays would need to be performed in the future to confirm their suitability as drug delivery candidates.Fundação para a Ciência e a TecnologiaNúcleo de Pesquisa em Biodiversidade e Biotecnologia BIOTEC Campus Ministro Reis Velloso Universidade Federal do Piauí UFPILaboratório de Polímeros LabPol Campus do Pici Universidade Federal do Ceará UFCBioprospectum Lda UPTECGlial Cell Biology Lab i3S UPUCIBIO/REQUIMTE Departamento de Química e Bioquímica Faculdade de Ciências Universidade do PortoREQUIMTE/LAQV Instituto Superior de Engenharia do Instituto Politécnico do Porto ISEPInstituto Federal de Educação Ciência e Tecnologia de São Paulo Campus MatãoUniversidade Estadual Paulista UNESP Campus Experimental de ItapevaNúcleo de Pesquisa em Morfologia e Imunologia Aplicada NuPMIA Área de Morfologia Faculdade de Medicina FM Universidade de Brasília UnBUniversidade Estadual Paulista UNESP Campus Experimental de ItapevaFundação para a Ciência e a Tecnologia: SFRH/BD/95983/2013Fundação para a Ciência e a Tecnologia: SFRH/BD/97995/2013Universidade Federal do Piauí UFPIUniversidade Federal do Ceará UFCUPTECUPUniversidade do PortoISEPCiência e Tecnologia de São PauloUniversidade Estadual Paulista (Unesp)Universidade de Brasília (UnB)do Amaral Rodrigues, Jessicade Araújo, Alyne RodriguesPitombeira, Nadia AlinePlácido, Alexandrade Almeida, Miguel PeixotoVeras, Leiz Maria CostaDelerue-Matos, CristinaLima, Filipe Camargo Dalmatti AlvesNeto, Augusto Batagin [UNESP]de Paula, Regina Célia MonteiroFeitosa, Judith Pessoa AndradeEaton, PeterLeite, José Roberto Souza A.da Silva, Durcilene Alves2019-10-06T16:16:56Z2019-10-06T16:16:56Z2019-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article965-972http://dx.doi.org/10.1016/j.ijbiomac.2019.01.206International Journal of Biological Macromolecules, v. 128, p. 965-972.1879-00030141-8130http://hdl.handle.net/11449/18871410.1016/j.ijbiomac.2019.01.2062-s2.0-85061324050Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Biological Macromoleculesinfo:eu-repo/semantics/openAccess2021-10-23T19:49:54Zoai:repositorio.unesp.br:11449/188714Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:49:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine |
title |
Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine |
spellingShingle |
Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine do Amaral Rodrigues, Jessica Acetic anhydride (PubChem CID: 7918) Acetone (PubChem CID: 180) Acetylation Alkaloid Cashew gum Formamide (PubChem CID: 713) Hydrochloric acid (PubChem CID: 313) Pyridine (PubChem CID: 1049) Sodium hydroxide (PubChem CID: 14798) |
title_short |
Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine |
title_full |
Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine |
title_fullStr |
Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine |
title_full_unstemmed |
Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine |
title_sort |
Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine |
author |
do Amaral Rodrigues, Jessica |
author_facet |
do Amaral Rodrigues, Jessica de Araújo, Alyne Rodrigues Pitombeira, Nadia Aline Plácido, Alexandra de Almeida, Miguel Peixoto Veras, Leiz Maria Costa Delerue-Matos, Cristina Lima, Filipe Camargo Dalmatti Alves Neto, Augusto Batagin [UNESP] de Paula, Regina Célia Monteiro Feitosa, Judith Pessoa Andrade Eaton, Peter Leite, José Roberto Souza A. da Silva, Durcilene Alves |
author_role |
author |
author2 |
de Araújo, Alyne Rodrigues Pitombeira, Nadia Aline Plácido, Alexandra de Almeida, Miguel Peixoto Veras, Leiz Maria Costa Delerue-Matos, Cristina Lima, Filipe Camargo Dalmatti Alves Neto, Augusto Batagin [UNESP] de Paula, Regina Célia Monteiro Feitosa, Judith Pessoa Andrade Eaton, Peter Leite, José Roberto Souza A. da Silva, Durcilene Alves |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Piauí UFPI Universidade Federal do Ceará UFC UPTEC UP Universidade do Porto ISEP Ciência e Tecnologia de São Paulo Universidade Estadual Paulista (Unesp) Universidade de Brasília (UnB) |
dc.contributor.author.fl_str_mv |
do Amaral Rodrigues, Jessica de Araújo, Alyne Rodrigues Pitombeira, Nadia Aline Plácido, Alexandra de Almeida, Miguel Peixoto Veras, Leiz Maria Costa Delerue-Matos, Cristina Lima, Filipe Camargo Dalmatti Alves Neto, Augusto Batagin [UNESP] de Paula, Regina Célia Monteiro Feitosa, Judith Pessoa Andrade Eaton, Peter Leite, José Roberto Souza A. da Silva, Durcilene Alves |
dc.subject.por.fl_str_mv |
Acetic anhydride (PubChem CID: 7918) Acetone (PubChem CID: 180) Acetylation Alkaloid Cashew gum Formamide (PubChem CID: 713) Hydrochloric acid (PubChem CID: 313) Pyridine (PubChem CID: 1049) Sodium hydroxide (PubChem CID: 14798) |
topic |
Acetic anhydride (PubChem CID: 7918) Acetone (PubChem CID: 180) Acetylation Alkaloid Cashew gum Formamide (PubChem CID: 713) Hydrochloric acid (PubChem CID: 313) Pyridine (PubChem CID: 1049) Sodium hydroxide (PubChem CID: 14798) |
description |
The natural alkaloid epiisopiloturine has recently become the focus of study for various medicinal properties, particularly for its anti-inflammatory and antischistosomal effect. The incorporation of active molecules in natural polymeric matrices has garnered increasing interest during recent decades. A new derivative of cashew gum successfully obtained by gum acetylation has shown great potential as a carrier in controlled drug release systems. In this work, epiisopiloturine was encapsulated in acetylated cashew gum nanoparticles in order to increase solubility and allow slow release, whereas the morphology results were supported by computer simulations. The particles were produced under a variety of conditions, and thoroughly characterized using light scattering and microscopic techniques. The particles were spherical and highly stable in solution, and showed drug incorporation at high levels, up to 55% efficiency. Using a dialysis-based in vitro assay, these particles were shown to release the drug via a Fickian diffusion mechanism, leading to gradual drug release over approximately 6 h. These nanoparticles show potential for the use as drug delivery system, while studies on their potential anti-inflammatory action, as well as toxicity and efficacy assays would need to be performed in the future to confirm their suitability as drug delivery candidates. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:16:56Z 2019-10-06T16:16:56Z 2019-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ijbiomac.2019.01.206 International Journal of Biological Macromolecules, v. 128, p. 965-972. 1879-0003 0141-8130 http://hdl.handle.net/11449/188714 10.1016/j.ijbiomac.2019.01.206 2-s2.0-85061324050 |
url |
http://dx.doi.org/10.1016/j.ijbiomac.2019.01.206 http://hdl.handle.net/11449/188714 |
identifier_str_mv |
International Journal of Biological Macromolecules, v. 128, p. 965-972. 1879-0003 0141-8130 10.1016/j.ijbiomac.2019.01.206 2-s2.0-85061324050 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Biological Macromolecules |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
965-972 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965478116917248 |