Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/s2175-97902022e191073 http://hdl.handle.net/11449/241378 |
Resumo: | Gabapentin is an antiepileptic drug prescribed for several neuropathic pain conditions. This study aimed to evaluate gabapentin (GAB) trough plasma concentration range and the applicability of therapeutic drug monitoring in patients with neuropathic pain. Fifty-three patients with neuropathic pain, aged 20 to 75, received gabapentin as treatment for at least 7 days. Gabapentin plasma concentration was sampled before GAB administration and quantified by liquid chromatography with a UV detector. GAB trough plasma concentration ranged between 0.40 and 11.94 µg/mL in patients with chronic neuropathic pain. No differences were observed in terms of GAB plasma concentrations between responsive and non-responsive patients. Our data suggest that the reference ranges suggested in the literature for patients with epilepsy should not be used for patients with neuropathic pain. Therapeutic drug monitoring of GAB was shown to be an important tool to assess treatment adherence. |
id |
UNSP_626a1311227be53a845ca1f1373039db |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/241378 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic painGabapentinNeuropathic painTherapeutic drug monitoringGabapentin is an antiepileptic drug prescribed for several neuropathic pain conditions. This study aimed to evaluate gabapentin (GAB) trough plasma concentration range and the applicability of therapeutic drug monitoring in patients with neuropathic pain. Fifty-three patients with neuropathic pain, aged 20 to 75, received gabapentin as treatment for at least 7 days. Gabapentin plasma concentration was sampled before GAB administration and quantified by liquid chromatography with a UV detector. GAB trough plasma concentration ranged between 0.40 and 11.94 µg/mL in patients with chronic neuropathic pain. No differences were observed in terms of GAB plasma concentrations between responsive and non-responsive patients. Our data suggest that the reference ranges suggested in the literature for patients with epilepsy should not be used for patients with neuropathic pain. Therapeutic drug monitoring of GAB was shown to be an important tool to assess treatment adherence.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Department of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University (UNESP), SPSchool of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP), SPDepartment of Neurosciences and Behavioral Sciences Ribeirão Preto Medical School University of São Paulo (USP), SPDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University (UNESP), SPCAPES: 001Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Yamamoto, Priscila Akemi [UNESP]Benzi, Jhohann Richard de LimaDach, Fabíolade Moraes, Natália Valadares [UNESP]2023-03-01T20:59:18Z2023-03-01T20:59:18Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/s2175-97902022e191073Brazilian Journal of Pharmaceutical Sciences, v. 58.2175-97901984-8250http://hdl.handle.net/11449/24137810.1590/s2175-97902022e1910732-s2.0-85134571745Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Pharmaceutical Sciencesinfo:eu-repo/semantics/openAccess2024-06-24T13:46:12Zoai:repositorio.unesp.br:11449/241378Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:23:33.553248Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain |
title |
Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain |
spellingShingle |
Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain Yamamoto, Priscila Akemi [UNESP] Gabapentin Neuropathic pain Therapeutic drug monitoring |
title_short |
Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain |
title_full |
Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain |
title_fullStr |
Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain |
title_full_unstemmed |
Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain |
title_sort |
Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain |
author |
Yamamoto, Priscila Akemi [UNESP] |
author_facet |
Yamamoto, Priscila Akemi [UNESP] Benzi, Jhohann Richard de Lima Dach, Fabíola de Moraes, Natália Valadares [UNESP] |
author_role |
author |
author2 |
Benzi, Jhohann Richard de Lima Dach, Fabíola de Moraes, Natália Valadares [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Yamamoto, Priscila Akemi [UNESP] Benzi, Jhohann Richard de Lima Dach, Fabíola de Moraes, Natália Valadares [UNESP] |
dc.subject.por.fl_str_mv |
Gabapentin Neuropathic pain Therapeutic drug monitoring |
topic |
Gabapentin Neuropathic pain Therapeutic drug monitoring |
description |
Gabapentin is an antiepileptic drug prescribed for several neuropathic pain conditions. This study aimed to evaluate gabapentin (GAB) trough plasma concentration range and the applicability of therapeutic drug monitoring in patients with neuropathic pain. Fifty-three patients with neuropathic pain, aged 20 to 75, received gabapentin as treatment for at least 7 days. Gabapentin plasma concentration was sampled before GAB administration and quantified by liquid chromatography with a UV detector. GAB trough plasma concentration ranged between 0.40 and 11.94 µg/mL in patients with chronic neuropathic pain. No differences were observed in terms of GAB plasma concentrations between responsive and non-responsive patients. Our data suggest that the reference ranges suggested in the literature for patients with epilepsy should not be used for patients with neuropathic pain. Therapeutic drug monitoring of GAB was shown to be an important tool to assess treatment adherence. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T20:59:18Z 2023-03-01T20:59:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/s2175-97902022e191073 Brazilian Journal of Pharmaceutical Sciences, v. 58. 2175-9790 1984-8250 http://hdl.handle.net/11449/241378 10.1590/s2175-97902022e191073 2-s2.0-85134571745 |
url |
http://dx.doi.org/10.1590/s2175-97902022e191073 http://hdl.handle.net/11449/241378 |
identifier_str_mv |
Brazilian Journal of Pharmaceutical Sciences, v. 58. 2175-9790 1984-8250 10.1590/s2175-97902022e191073 2-s2.0-85134571745 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129316507090944 |